Pattern of lipid alterations in subclinical hypothyroidism: response to Levothyroxine replacement

  • Dr Nazir Ahmad Pala Lecturer, Department of Medicine, Government Medical College, Srinagar, Jammu and Kashmir, India
  • Dr Mohd Ashraf Assistant Professor, Department of Medicine, Government Medical College, Srinagar, Jammu and Kashmir, India
  • Dr Badrinath Bhoughal Associate Professor, Department of Medicine, Government Medical College, Srinagar, Jammu and Kashmir, India
Keywords: Anti-TPO antibodies, Levothyroxine, Lipid Profile, Subclinical hypothyroidism

Abstract

Objectives: (1) To assess the association of subclinical hypothyroidism (SCH) and lipid profile (2) To quantify the effect of thyroxine treatment on lipid profile.

Methods: In a non-randomized matched design, 320 patients who were detected to have SCH and 180 euthyroid controls, matched for age and BMI (body-mass index), werestudied for lipid parameters. Subjects with SCH were further subdivided on the basis of their thyroid functional status: SCH with TSH≤10.0 mIU/L (SCH-1) and SCH with TSH>10 mIU/L (SCH-2). Subjects in SCH-2 group were started on thyroxine replacement and were followed up after 3 months with a repeat lipid profile.

Results: Mean total cholesterol (TC) and low-density lipoprotein (LDL) levels were higher and mean high-density lipoprotein (HDL) significantly lower in SCH (SCH-1 and SCH-2) compared to euthyroid controls, but there was no statistically significant difference in the mean triglyceride (TG) levels. Subjects in SCH-2 group had significantly higher mean LDL and lower mean HDL compared to SCH-1 group. There was a significant reduction in mean TC and LDL and increase in HDL after treatment with thyroxine, while there was no significant difference among the mean TG levels.

Conclusion: Subclinical hypothyroidism is associated with TSH dependent rise in TC and LDL and fall in HDL compared to controls. Achieving euthyroid status with thyroxine has a favourable effect on lipid profile

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Pattern of lipid alterations in subclinical hypothyroidism: response to Levothyroxine replacement
CITATION
DOI: 10.17511/ijmrr.2017.i09.06
Published: 2017-09-30
How to Cite
1.
Pala NA, Ashraf M, Bhoughal B. Pattern of lipid alterations in subclinical hypothyroidism: response to Levothyroxine replacement. Int J Med Res Rev [Internet]. 2017Sep.30 [cited 2021Jun.18];5(9):865-71. Available from: https://ijmrr.medresearch.in/index.php/ijmrr/article/view/922
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