International Journal of Medical Research and Review 2022-09-27T04:48:15+00:00 Mr Daulat Ram Open Journal Systems <p><em><strong>ISSN: <a href="" target="_blank" rel="noopener">2320-8686 (Online)</a>, <a href="" target="_blank" rel="noopener">2321-127X (Print)</a></strong></em></p> A Multi-centre Study to Evaluate the Long-Term Efficacy and Safety of Biosimilar Infliximab (Infimab™) in Ankylosing Spondylitis in Real-world Clinical Settings - A perspective from Eastern India 2022-08-30T10:38:55+00:00 Pradip Kumar Sarma Sukumar Mukherjee R N Sarkar Santosh Kumar Mandal Pradeepta Patra Tanoy Bose Ajit Surin Santa Naorem Kaushik Basu J.R. Parida CT Arunachalam <p><strong>Introduction: </strong>Owing to dearth of data on infliximab biosimilars in Indian patients, a pan-India case database-based study with infliximab biosimilar BOW015 (Infimab™) was carried out to capture its efficacy and safety in real world clinical settings in India. Here, we assessed its efficacy and safety in ankylosing spondylitis (AS) among patients in the East India cohort.</p> <p><strong>Materials and m</strong><strong>ethods: </strong>Data were collected from multiple centers across the eastern region of India. Patients diagnosed with AS, within the preceding 4-6 months during the preceding one year were included in the study. Patients who were given BOW015 for other indications, prior innovator infliximab or other biologics were excluded from the study. Primary variable was Ankylosing Spondylitis Disease Activity Scale (ASDAS) response defined as change of &gt; 2 in the ASDAS score from the baseline by 4-6 months of follow up.</p> <p><strong>Results: </strong>The cohort consisted of 149 patients, predominantly male (69.8%), with mean (±SD) age of 36.75 (±11.11) years and mean (±SD) body weight of 58.26 (±15.4) kgs. Of the treated patients, 91 (61.1%) patients were administered four doses, 10 (6.7%) patients were administered three doses, 37 (24.8%) patients were administered two doses and 11 (7.4%) patients were administered only a single dose of BOW015. In the final analysis set, 81 patients had data at baseline and 4<sup>th</sup> visit. Among the 81 patients, 74 (91%) patients achieved major improvement, 5 (6%) patients achieved clinically important improvement and 2 (3%) were non-responders at 4<sup>th</sup> visit. Secondarily, cross categorization of the cohort into disease activity categories by number of infusions administered from baseline to 4<sup>th</sup> visit and assessment of trends in Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) scores were also carried out and these too confirmed the efficacy of BOW015.</p> <p><strong>Conclusion: </strong>Infimab™ (BOW015) showed significant improvement in ASDAS and BASDAI in patients with AS at the end of 4-6 months of follow up with its clinical benefits being apparent as early as first dose of BOW015.</p> 2022-08-25T00:00:00+00:00 Copyright (c) 2022 Author (s). Published by Siddharth Health Research and Social Welfare Society New Onset of Diabetes in Adults with Post-Covid Infection in a TertiaryCare Hospital 2022-09-27T04:42:52+00:00 Karthik Meruva Alekhya Abburu Kainat Aftab Irene Priscilla <p>Aim/Scope: This study is aimed to investigate the incidence of diabetes after infection with thecoronavirus (COVID-19). SARS COV2 is a rapidly spreading disease which causes morbidity andmortality. One of the most important complications associated with covid 19 is Diabetes Mellitus.</p> <p>Materials &amp; Methods: This was a retrospective descriptive study of (50 diabetic and 50 non-diabetic) patients who had a previous history of covid-19 and who are infected during the secondwave (Aug’21-Oct’21) at a tertiary care hospital, Hyderabad, India. Data collected including patientdemographic and baseline characteristics like patient’s age, sex and history of covid infection wereanalyzed using Statistical Package for Social Sciences (SPSS) software version 22.0.</p> <p>Results: In thestudy among covid infected(n=50) subjects who were tested diabetic after Long Covid, 28(56%)were hospitalized, 13(26%) were found to have ICU admissions and 9(18%) were discharged withmild covid symptoms and the subjects(n=50) who didn’t have any symptoms of diabetes after LongCovid, majority 32(64%) were found to be discharged with mild covid symptoms, 5(10%) werefound to have ICU admissions and 13 (26%)were found to be hospitalized with the critical covidcondition. It was observed that patients hospitalized with critical covid conditions were susceptible toonset of diabetes (p-value: 0.10)</p> <p>Conclusion: This study showed a high incidence of complicationsin patients infected with COVID-19 with diabetes being the most common one. Patients with poorglycemic control should be routinely monitored and treated appropriately</p> 2022-09-07T00:00:00+00:00 Copyright (c) 2022 Author (s). Published by Siddharth Health Research and Social Welfare Society Opting Nursing as a Profession among B.Sc. Nursing Students in India: A descriptive survey research 2022-09-27T04:48:15+00:00 Khumukcham Anupama Devi Sudhakar Kumar Singh <p>Introduction: Nursing as a career is widely accepted to be viewed positively by society because itprovides job security, mobility, and career variety. As this paper demonstrates, the desire to helpand care for others remains the primary reason for choosing nursing in the twenty-first century.</p> <p>Objective: The purpose of this paper is to determine why B.Sc. Nursing students choose nursing asa career and what factors play a role in their choice. Method and Material: Quantitative,descriptive survey research design adopted and by using convenience sampling collected 312respondents all over India. Self-questionnaires were developed in the google form, and circulatedamong B.Sc. Nursing students and information were collected.</p> <p>Result: Female respondents are fourfolds more and around 51% of respondents appeared in NEET exams before joining a nursing career.Another common misconception that plagues the nursing profession is that students choose nursingas a second career after failing to gain admission to medical school.</p> <p>Conclusion: In general, nursesare extremely enthusiastic about their jobs. Although there are numerous reasons why peoplechoose nursing as a profession, one constant is that nurses can make a difference in someone's life,as evidenced by all of the COVID-19 cases reported from around the world</p> 2022-09-13T00:00:00+00:00 Copyright (c) 2022 Author (s). Published by Siddharth Health Research and Social Welfare Society