International Journal of Medical Research and Review 2020-06-18T10:37:52+00:00 Dr D Sharad Gedam Open Journal Systems <p><em><strong>ISSN: 2320-8686 (Online), 2321-127X (Print),Bi Monthly, Indexed with Index Copernicus</strong></em></p> <p>International Journal of Medical Research &amp; Review (IJMRR) is commencing its publication from January 2013. It is a multidisciplinary, peer reviewed open access medical Journal. It is publishing Bimonthly now.</p> <p>International Journal of Medical Research &amp; Review (IJMRR) is published by Siddharth Health Research and Social Welfare Society which is registered under MP Society registration act, 1973.</p> <p>This is an open access journal which means that all content is freely available without any charges to the user or his/her institution. Users are allowed to read, download, copy, distribute, print, search, or link to the full texts of the articles in this journal without asking prior permission from the publisher or the author. This is in accordance with the BOAI definition of open access.</p> <p>We invite articles from all medical specialty like Anatomy, Physiology, Biochemistry, Pharmacology, Pathology, Forensic medicine, Preventive and social medicine, Ophthalmology, ENT, General medicine, Surgery, Obstetrics and Gynecology, Radiology, Anesthesia and all super-speciality medical Journals. The journal is concerned with epidemiological studies, clinical research, preventive medicine and dentistry, health services research, health education, health promotion, health economics, quality of life, analysis of risk and quality assessment</p> <p>International Journal of medical research and review has a strict <strong>anti-plagiarism policy</strong> and every manuscript submitted undergoes a rigorous editorial review followed by a <strong>double-blind peer-review</strong> process. Any article found to be plagiarized will be rejected with no further communication in this matter.</p> <p>We welcome articles from all medical specialties. We accept, in English Review articles, Research/Original articles, Systematic reviews, meta-analysis, debates, Case Reports, Case series, Research letters &amp; Letters to Editor.</p> <p>Our motto to is to provide an international platform to the large volume of research work which in going on all around the world. Our mission is to update medical fraternity with the latest knowledge. We are committed and promise to take this journal to greater heights. We request all readers to submit articles for the upcoming issue.</p> <p>We are already indexed with Index Copernicus, Google Scholar, Cross reference, Research Boble, etc. We are making efforts to get indexed with other International and National databases shortly.</p> <p>It full fill all criteria updated in Sepember 2015 for promotion by MCI (Medical Council of India). It is Indexed with Index Copernicus: <a href=";org=International+Journal+of+Medical+Research+and+Review,p4184,3.html" target="_blank" rel="noopener">Link</a></p> Incidence and profile of neurological disorders in alcohol dependents 2020-06-12T06:16:10+00:00 Vijay Singh Baghel Vasant Shrivastava <p>Background: Alcohol is one of the most abused substances in the world. Alcohol has been known to produce toxic effects in almost every organ system in the body, many of these medical conditions can be attributed to the direct toxic effect of alcohol and its metabolites, whereas others are indirect sequelae that may result from nutritional deficiency particularly thiamine. A neurological complication of alcohol dependence is extremely common and affects every level of neuroaxis including the Brain-Peripheral nervous system-Muscle.</p> <p>Aim &amp; Objective: To quantify the number of different neurological disorders in alcohol-dependent patients and to the established relationship between the frequency of these disorders with type, duration, amount, and frequency of alcohol intake.</p> <p>Method &amp; Material: A cross-sectional study was conducted in 100 alcoholics who came to tertiary care centers of central India in the 1-year duration. Demographic data, questions related to their alcohol consumption, and Neurological examination of all patients were done as pre-decided protocol. Informed consent was obtained from all patients. Data was entered and analyzed using appropriate software.</p> <p>Result: Study participants were mostly (70%) in the age group of 21 to 40 years, 87% resided in the urban area, 81% were Hindu. 78% were educated up to class 8th and 76% were employed with any kind of jobs. There were 64% of cases that had any kind of neurological manifestation, 20% had peripheral neuropathy and less than 10% has severe manifestation Korsakoff’s psychosis, and cerebellar degeneration.</p> <p>Conclusion: Neurological manifestations were common among alcohol dependents, but it variably depends on the amount, pattern, chronicity, and type of alcohol consumption. There is a need for further studies that specifically point out alcohol-related nervous manifestations.</p> 2020-05-30T07:51:02+00:00 Copyright (c) 2020 Author (s). Published by Siddharth Health Research and Social Welfare Society Conformal radiotherapy plans for palliative bone metastasis - comparison of dosimetric parameters 2020-06-12T07:35:45+00:00 Naina Gupta Dr. Pavan Kumar Piyush Kumar S. Navitha Ankita Mehta Arvind Chauhan <p>Background:Palliative radiotherapy offers significant relief in the huge physical distress of patients with bony metastasis. The enormous potential of conformal techniques has not been tested in palliative settings. However,the increasing life span of patients with metastatic disease demands to optimize the radiotherapy techniques to provide maximal durable symptomatic relief. Despitean increase in the utilization of the 3DCRT technique for palliative bony metastasis, the optimal beam arrangement remains unknown.</p> <p>Materials and Methods:Ten patients of vertebral bony metastasis were retrospectively selected and four virtual 3DCRT plans were generated for each patient. The field approaches were a single field, two fields, three fields and five field approaches. For PTV, D90, D50, Dmean, Conformity index (CI) were evaluated.Dmean was evaluated for the esophagus, bowel, kidneys, and combined lungs. Dose-volume histograms were computed for the various treatment plans and compared. Statistical analysis was done by ANOVA test.</p> <p>Results:A total of forty radiotherapy plans were generated. PTV parameters were significantly better with two field plans over one field plans in terms of D90 (p= 0.002), D50 (p= 0.02), Dmean(p=0.0009). Dmeanwassignificantly better with three field approach compared to two field approach (p=0.0006). The Dmeanwas significantly increased for organs at risk in two fields and three field plans.Five field approach did not showan advantage in terms of dosimetry of PTV but there was a significant rise in the dose to Organs at risk (OAR’s).</p> <p>Conclusion:The three field plans showed better dose distribution to the PTV with an acceptable increase in the dose to OAR’s.</p> 2020-06-12T06:07:17+00:00 Copyright (c) 2020 Author (s). Published by Siddharth Health Research and Social Welfare Society Haematological toxicity in cancer cervix patients treated with concurrent chemoradiation by conventional technique- correlation with bone marrow radiation dose 2020-06-18T10:31:39+00:00 Prachi Upadhyay Pavan Kumar Piyush Kumar Ayush Garg Arvind Kumar Chauhan <p>Introduction: The standard of care for treatment of cancer cervix is concurrent chemoradiation followed by brachytherapy in the majority of cases. Conventional radiotherapy with chemotherapy causes haematological toxicities which may be related to radiation to pelvic bone marrow. The present study aims to study the haematological toxicities and correlate with the mean dose to the bone marrow.</p> <p>Material and Methods: Retrospective data of cancer patients treated in the institute in the year 2019 was retrieved. Haematological toxicities were analyzed in terms of CTCAE criteria. Mean dose to bone marrow was calculated after the delineation in the CT scan. The correlation between haematological toxicity and mean bone marrow was done using a paired t-test for statistical significance.</p> <p>Results: The data of 20 patients were retrieved. Anaemia Grade, I and Grade II-IV was seen in 65% and 35% respectively. Leukopenia Grade I and Grade II-IV were seen in 85% and 15% respectively and Lymphopenia Grade I and Grade II-Iv were seen in 55% and 45% respectively. The mean dose to bone marrow did not show any statistical significance with the severity of haematological toxicity. There was no Grade II-IV toxicity of neutropenia and thrombocytopenia.</p> <p>Conclusion: Conventional radiotherapy can safely be practice for patients with cancer cervix with acceptable haematological toxicities.</p> 2020-06-18T08:47:09+00:00 Copyright (c) 2020 Author (s). Published by Siddharth Health Research and Social Welfare Society A comparative study of PSI and Curb-65 scoring systems in predicting ICU admissions and mortality in cases of community-acquired pneumonia 2020-06-18T10:37:52+00:00 Prashant Patil Arun Tyagi Manoj Waghmare A.K. Srivastava Marcia Waran <p>Background:Community-acquired pneumonia (CAP) is a leading cause of morbidity and mortality worldwide. Despite advanced diagnostic modalities and treatment options, CAP is the fourth leading cause of death in developing countries.Several severity scores have been proposed to guide initial decision making on hospitalization and to predict the outcome. Pneumonia Severity Index (PSI) and CURB 65 are the two most widely used scoring systems to prognosticate pneumonia.</p> <p>Aim: To compare the efficacy of PSI and CURB 65 scoring systems inprognosticating the ICU admission and outcome in cases of CAP.</p> <p>Methodology: This wasan observational study conducted at a tertiary care hospital in westernMaharashtra.A hundred patients of CAP fulfilling the inclusion criteria were enrolled in the study, classified as per CURB 65 and PSI system and their outcome compared.</p> <p>Result: The study subjects comprised of 100 patients (64 men and 36 women) of CAP. Twenty-four patients needed ICU admission.In both PSI and CURB-65 risk scoring systems, the need for intensive care unit (ICU) admission and mortality rates increased progressively with increasing scores.PSI class ≥IV and CURB 65 ≥III had 77.52% and 40.24% sensitivity and 88.46% and 69.48% specificity respectively in predicting ICU admissions. The PSI class ≥IV had more sensitivity and specificity in predicting ICU admission than CURB-65.CURB 65 class III and IV had sensitivity86.59% and 89.64% and specificity 89.64% and 97.54% respectivelyin predicting mortality, while PSI class IV and Vhadsensitivity68.92% and 72.58% and specificity 24.74% and 54.86% respectively. CURB 65 had more sensitivity and specificity than PSI in predicting mortality.</p> <p>Conclusion: The PSI is better in predicting the need for ICU admission and CURB 65 is a better predictor of mortality in cases of community-acquired pneumonia.</p> 2020-06-18T09:22:12+00:00 Copyright (c) 2020 Author (s). Published by Siddharth Health Research and Social Welfare Society