International Journal of Medical Research and Review

An Evaluating the Accuracy of Endoscopic diagnosis : A comparative analysis with Histopathology in Upper and Lower GI Tract Disorders

Smriti Rathore — 2025-07-24

ABSTRACT

Background: Endoscopy and histopathology are complementary tools in diagnosing gastrointestinal (GI) disorders. While endoscopy provides macroscopic visualization, histopathology offers definitive microscopic diagnosis. This study aims to evaluate the correlation between endoscopic findings and histopathological results in upper and lower GI disorders.

Objectives:

To assess the diagnostic correlation between endoscopic impressions and histopathological diagnosis.
To determine the accuracy of endoscopy in detecting various upper and lower GI tract pathologies.

Methods: A retrospective study was conducted on 200 patients undergoing upper GI endoscopy (UGIE) and Colonoscopy for GI symptoms. Endoscopic findings were documented and correlated with histopathology reports of biopsy specimens.

Results: Endoscopic and histopathological findings were consistent in 92% of upper GI cases and 90.6% of lower GI cases. Among 125 upper GI cases, 115 were concordant, and among 75 lower GI cases, 68 were concordant. Highest correlation was observed in cases of gastric ulcers, esophagitis, colorectal polyps, and inflammatory bowel disease (IBD) and malignancy.

Conclusion: Endoscopy is a reliable initial diagnostic tool. However, histopathological confirmation is essential, especially in cases with subtle or ambiguous endoscopic findings.

Keywords: Endoscopy, Histopathology, GI Disorders, Upper GI, Colonoscopy.

To evaluate the relationship between BODE Index and CRP in COPD patients in a tertiary care centre

Poonam gupta — 2025-08-05

Background: Chronic obstructive pulmonary disease (COPD) is a respiratory disease which is associated with abnormal inflammatory response of lungs to stimuli leading to a progressive airflow limitation that is not fully reversible. COPD is the third leading cause of death worldwide with an estimated burden of COPD about 37.8million cases. Of late, the disease is being discussed widely due to its systemic nature. A combined index of multiple mortality predictors for COPD known as the “BODE index” was developed to understand this aspect of the disease. The BODE index, which includes Body Mass Index (BMI), Airflow Obstruction (FEV1), Dyspnea (MMRC), and Exercise Capacity (6MWT), is a multidimensional tool for assessing disease severity. C-reactive protein (CRP), an acute-phase reactant, is commonly elevated in COPD and may reflect systemic inflammatory burden.
Objective: This study aimed to evaluate the relationship between CRP levels and the BODE index in stable COPD patients.
Methods: A cross-sectional study was conducted on 110 stable COPD patients. CRP levels and BODE index components were measured and analyzed using Pearson coefficient correlation.
Results: A weak but statistically significant positive correlation was found between CRP and the BODE index (r = 0.258, p = 0.006). CRP was also significantly associated with lower FEV1, shorter 6MWT distance, and higher MMRC scores.
Conclusion: CRP may be a useful marker for systemic inflammation and disease severity in stable COPD patients.

A Study to Assess The Knowledge Regarding Silicosis among the Workers of Stone Cutting and Art Industrial Area Sikandra, Dausa, Rajasthan, With a View to Develop an Information Booklet

Jogendra Sharma — 2025-09-16

Introduction: Silicosis is an incurable occupational lung disease resulting from prolonged inhalation of crystalline silica dust, primarily affecting workers in the stone cutting and stone art industries.Despite its severe health implications, knowledge regarding silicosis among workers remains limited, leading to increased morbidity and mortality.

Materials and Methods: A descriptive design within a quantitative research approach was employed for this study Data was collected using a self-structured knowledge interview schedule to evaluate workers knowledge about Silicosis A convenient sampling method was employed to select 100 workers from the Stone Cutting and Art Industrial area of Sikandra, Dausa, Rajasthan. The structured knowledge interview schedule gathered both Background details and knowledge-related questions about Silicosis. The collected data was organized, analyzed, and interpreted utilizing descriptive statistics.

Results: The results revealed that 62% of participants had average knowledge, 35% had good knowledge, and 3% had poor knowledge regarding Silicosis. The mean score was 18.28, with a standard deviation of 3.9. , The overall average knowledge score stood at (score 11 to 20) 33.33% to 66.66% . A statistically significant relationship was identified between knowledge and the workers education and monthly income (p < 0.05), while no association was observed with other demographic factors such as age, work experience, and sources of information

Conclusion: The study highlights the need for enhanced education and awareness programs to improve workers' knowledge of silicosis. Based on the findings, an information booklet was developed to promote health education and preventive measures. The study emphasizes the importance of workplace interventions, regular health check-ups, and policy implementation to mitigate the risks of silicosis.