International Journal of Medical Research and Review

An Evaluating the Accuracy of Endoscopic diagnosis : A comparative analysis with Histopathology in Upper and Lower GI Tract Disorders

Smriti Rathore — 2025-07-24

ABSTRACT

Background: Endoscopy and histopathology are complementary tools in diagnosing gastrointestinal (GI) disorders. While endoscopy provides macroscopic visualization, histopathology offers definitive microscopic diagnosis. This study aims to evaluate the correlation between endoscopic findings and histopathological results in upper and lower GI disorders.

Objectives:

To assess the diagnostic correlation between endoscopic impressions and histopathological diagnosis.
To determine the accuracy of endoscopy in detecting various upper and lower GI tract pathologies.

Methods: A retrospective study was conducted on 200 patients undergoing upper GI endoscopy (UGIE) and Colonoscopy for GI symptoms. Endoscopic findings were documented and correlated with histopathology reports of biopsy specimens.

Results: Endoscopic and histopathological findings were consistent in 92% of upper GI cases and 90.6% of lower GI cases. Among 125 upper GI cases, 115 were concordant, and among 75 lower GI cases, 68 were concordant. Highest correlation was observed in cases of gastric ulcers, esophagitis, colorectal polyps, and inflammatory bowel disease (IBD) and malignancy.

Conclusion: Endoscopy is a reliable initial diagnostic tool. However, histopathological confirmation is essential, especially in cases with subtle or ambiguous endoscopic findings.

Keywords: Endoscopy, Histopathology, GI Disorders, Upper GI, Colonoscopy.

To evaluate the relationship between BODE Index and CRP in COPD patients in a tertiary care centre

Poonam gupta — 2025-08-05

Background: Chronic obstructive pulmonary disease (COPD) is a respiratory disease which is associated with abnormal inflammatory response of lungs to stimuli leading to a progressive airflow limitation that is not fully reversible. COPD is the third leading cause of death worldwide with an estimated burden of COPD about 37.8million cases. Of late, the disease is being discussed widely due to its systemic nature. A combined index of multiple mortality predictors for COPD known as the “BODE index” was developed to understand this aspect of the disease. The BODE index, which includes Body Mass Index (BMI), Airflow Obstruction (FEV1), Dyspnea (MMRC), and Exercise Capacity (6MWT), is a multidimensional tool for assessing disease severity. C-reactive protein (CRP), an acute-phase reactant, is commonly elevated in COPD and may reflect systemic inflammatory burden.
Objective: This study aimed to evaluate the relationship between CRP levels and the BODE index in stable COPD patients.
Methods: A cross-sectional study was conducted on 110 stable COPD patients. CRP levels and BODE index components were measured and analyzed using Pearson coefficient correlation.
Results: A weak but statistically significant positive correlation was found between CRP and the BODE index (r = 0.258, p = 0.006). CRP was also significantly associated with lower FEV1, shorter 6MWT distance, and higher MMRC scores.
Conclusion: CRP may be a useful marker for systemic inflammation and disease severity in stable COPD patients.