Serum Lipid Profile in Early Pregnancy as a Predictor of Preeclampsia
Keywords:
Dyslipidemia, Lipid profile, Preeclampsia, Pregnancy
Abstract
Background: The study aimed to investigate the relationship between early pregnancy serum lipid concentrations and risk of preeclampsia. Material and
Methods: Serum lipid profile was measured enzymatically by standardized assay in 270 pregnant women between 13-20 weeks of gestation. Out of these total number 58 subjects developed preeclampsia (study group) while 212 subjects remained normotensive (control group).
Results: The mean serum level of total cholesterol (TC), triglycerides (TG), low density lipoprotein cholesterol (LDL-C) and very low density lipoprotein cholesterol (VLDL-C) was significantly higher in preeclamptic women as compared to normotensive pregnant women. While preeclamptic women showed significant fall in high density lipoprotein cholesterol HDL-C) level as compared to normal pregnant women.
Conclusion: The measurement of serum lipid profile in early pregnancy may serve as early predictor of preeclampsia.
Downloads
Download data is not yet available.
References
1. Ghulmiyyah L, Sibai B. Maternal mortality from preeclampsia/ eclampsia. Seminars in Perinatology. 2012; 36:56–59. [PubMed]
2. Moodley J. Maternal deaths associated with hypertensive disorders of pregnancy. A population-based study Hypertension in Pregnancy. 2004; 23:247–256. [PubMed]
3. Duley L. The global impact of pre-eclampsia and eclampsia. Seminars in Perinatology. 2009; 33:130–137. [PubMed]
4. WHO Recommendations for Prevention and Treatment of Preeclampsia and Eclampsia: WHO Department of Maternal and Child Health, Geneva, Switzerland. 2011.
5. Rao AK, Daniels K, El-Sayed YY, Moshesh MK, Caughey AB. Perinatal outcomes among Asian American and Pacific Islander women. Am J Obstet Gynecol. 2006;195: 834–838. [PubMed]
6. Lorentzen B, Henrisksen T. Plasma lipids and vascular dysfunction in preeclampsia. Semin Reprod Endocrinol. 1998; 16:33–39. [PubMed]
7. Dekker G, Sibai BM. Etiology and pathogenesis of preeclampsia: current concepts. Am J Obstet Gynecol. 1998;179:1359–1375. [PubMed]
8. Sattar N, Bendomir A, Berry C, Shepherd J, Greer IA, Packard C. Lipoprotein subfraction concentrations in preeclampsia: pathogenic parallels to atherosclerosis. Obstet Gynecol.1997;89:403–408. [PubMed]
9. Kaaja R, Tikkanen MJ, Viinikka L, Ylikorkala O. Serum lipoproteins, insulin, and urinary prostanoid metabolites in normal and hypertensive pregnant women. Obstet Gynecol.1995;85:353–356. [PubMed]
10. Gratacos E, Casals E, Sanllehy C, Cararach V, Alonso PL, Fortuny A. Variation in lipid levels during pregnancy in women with different types of hypertension. Acta Obstet Gynecol Scand.1996;75: 896–901. [PubMed]
11. Ogura K, Miyatake T, Fukui O, Nakamura T, Kameda T, Yoshino G. Low-density lipoprotein particle diameter in normal pregnancy and preeclampsia. J Atheroscler Thromb. 2002;9:42–47. [PubMed]
12. Lorentzen B, Drevon C, Endresen M, Henriksen T. Fatty acid pattern of esterified and free fatty acids in sera of women with normal and pre-eclamptic pregnancy. Br J Obstet Gynaecol.1995;102:530–537. [PubMed]
13. Hubel C, Mclaughlin M, Evans R, Hauth B, Sims C, Roberts J. Fasting serum triglycerides, free fatty acids, and malondialdehyde are increased in preeclampsia, are positively correlated, and decrease within 48 hours post partum. Am J Obstet Gynecol.1996;174:975–982. [PubMed]
14. Franz H, Wendler D. A controlled study of maternal serum concentrations of lipoproteins in pregnancy-induced hypertension. Arch Gynecol Obstet.1992;252:81–86. [PubMed]
15. Ware-Jauregui S, Sanchez SE, Zhang C, Laraburre G, King IB, Williams MA. Plasma lipid concentrations in pre-eclamptic and normotensive Peruvian women. Int J Gynecol Obstet. 1999;67:147–155. [PubMed]
16. Roberts JM, Pearson G, Cutler J, Lindheimer M. Summary of the NHLBI Working Group on Research on Hypertension During Pregnancy. Hypertension. 2003;41:437–44.
17. Caren G, Solomon, Seely EW. Preeclampsia searching for cause. New Eng J Med. 2004;350(7):641-42.
18. Robson SC. Hypertension and renal disease in pregnancy. 6th edition. Edmonds DK. editor. In: Dewhurst's Textbook of Obstetrics and Gynaecology for postgraduates. Blackwell Science, New York; 1999. p167-69.
19. Enquobahrie DA, Williams MA, Butler CL, Frderick IO, Miller RS, Luthy DA. Maternal plasma lipid concentration in early pregnancy and risk of preeclampsia. Am J Hypertens. 2004;17(7):574-81. [PubMed]
20. Lorentzen B, Endresen M, Clausen T, Henriksen T. Fasting serum free fatty acids and triglycerides are increased before 20 weeks of gestation in women who later develop preeclampsia. Hypertens Pregnancy.1994;13:103–109.
21. Clausen T, Djurovic S, Henriksen T. Dyslipidemia in early second trimester is mainly a feature of women with early onset pre-eclampsia. Br J Obstet Gynaecol. 2001;108:1081–1087. [PubMed]
22. Wladimiroff JW, Van den Elzen HJ, Cohen-Overbeek TE, De Bruijin AJ, Grobbee DE. Serum lipids in early pregnancy and risk of pre-eclampsia. Br J Obstet Gynaecol. 1996;103:117–122. [PubMed]
23. Craig SR, Amin RV, Russell DW, Paradise NF. Blood cholesterol screening influence of fasting state on cholesterol results and management decisions. J Gen Intern Med. 2000;15:395-99. [PubMed]
24. Schaefer EJ, Audelin MC, McNamara JR, et al. Comparison of fasting and postprandial plasma lipoproteins in subjects with and without coronary heart disease. Am J Cardiol. 2001;88:1129-33. [PubMed]
25. Endresen MJ, Lorentzen B, Henriksen T. Increased lipolytic activity and high ratio of free fatty acids to albumin in sera from women with preeclampsia leads to triglyceride accumulation in cultured endothelial cells. Am J Obstet Gynecol. 1992;167:440–447.
26. Sattar N, Greer IA. Pregnancy complications and maternal cardiovascular risk: opportunities for intervention and screening. Br Med J. 2002; 325:157–160.
2. Moodley J. Maternal deaths associated with hypertensive disorders of pregnancy. A population-based study Hypertension in Pregnancy. 2004; 23:247–256. [PubMed]
3. Duley L. The global impact of pre-eclampsia and eclampsia. Seminars in Perinatology. 2009; 33:130–137. [PubMed]
4. WHO Recommendations for Prevention and Treatment of Preeclampsia and Eclampsia: WHO Department of Maternal and Child Health, Geneva, Switzerland. 2011.
5. Rao AK, Daniels K, El-Sayed YY, Moshesh MK, Caughey AB. Perinatal outcomes among Asian American and Pacific Islander women. Am J Obstet Gynecol. 2006;195: 834–838. [PubMed]
6. Lorentzen B, Henrisksen T. Plasma lipids and vascular dysfunction in preeclampsia. Semin Reprod Endocrinol. 1998; 16:33–39. [PubMed]
7. Dekker G, Sibai BM. Etiology and pathogenesis of preeclampsia: current concepts. Am J Obstet Gynecol. 1998;179:1359–1375. [PubMed]
8. Sattar N, Bendomir A, Berry C, Shepherd J, Greer IA, Packard C. Lipoprotein subfraction concentrations in preeclampsia: pathogenic parallels to atherosclerosis. Obstet Gynecol.1997;89:403–408. [PubMed]
9. Kaaja R, Tikkanen MJ, Viinikka L, Ylikorkala O. Serum lipoproteins, insulin, and urinary prostanoid metabolites in normal and hypertensive pregnant women. Obstet Gynecol.1995;85:353–356. [PubMed]
10. Gratacos E, Casals E, Sanllehy C, Cararach V, Alonso PL, Fortuny A. Variation in lipid levels during pregnancy in women with different types of hypertension. Acta Obstet Gynecol Scand.1996;75: 896–901. [PubMed]
11. Ogura K, Miyatake T, Fukui O, Nakamura T, Kameda T, Yoshino G. Low-density lipoprotein particle diameter in normal pregnancy and preeclampsia. J Atheroscler Thromb. 2002;9:42–47. [PubMed]
12. Lorentzen B, Drevon C, Endresen M, Henriksen T. Fatty acid pattern of esterified and free fatty acids in sera of women with normal and pre-eclamptic pregnancy. Br J Obstet Gynaecol.1995;102:530–537. [PubMed]
13. Hubel C, Mclaughlin M, Evans R, Hauth B, Sims C, Roberts J. Fasting serum triglycerides, free fatty acids, and malondialdehyde are increased in preeclampsia, are positively correlated, and decrease within 48 hours post partum. Am J Obstet Gynecol.1996;174:975–982. [PubMed]
14. Franz H, Wendler D. A controlled study of maternal serum concentrations of lipoproteins in pregnancy-induced hypertension. Arch Gynecol Obstet.1992;252:81–86. [PubMed]
15. Ware-Jauregui S, Sanchez SE, Zhang C, Laraburre G, King IB, Williams MA. Plasma lipid concentrations in pre-eclamptic and normotensive Peruvian women. Int J Gynecol Obstet. 1999;67:147–155. [PubMed]
16. Roberts JM, Pearson G, Cutler J, Lindheimer M. Summary of the NHLBI Working Group on Research on Hypertension During Pregnancy. Hypertension. 2003;41:437–44.
17. Caren G, Solomon, Seely EW. Preeclampsia searching for cause. New Eng J Med. 2004;350(7):641-42.
18. Robson SC. Hypertension and renal disease in pregnancy. 6th edition. Edmonds DK. editor. In: Dewhurst's Textbook of Obstetrics and Gynaecology for postgraduates. Blackwell Science, New York; 1999. p167-69.
19. Enquobahrie DA, Williams MA, Butler CL, Frderick IO, Miller RS, Luthy DA. Maternal plasma lipid concentration in early pregnancy and risk of preeclampsia. Am J Hypertens. 2004;17(7):574-81. [PubMed]
20. Lorentzen B, Endresen M, Clausen T, Henriksen T. Fasting serum free fatty acids and triglycerides are increased before 20 weeks of gestation in women who later develop preeclampsia. Hypertens Pregnancy.1994;13:103–109.
21. Clausen T, Djurovic S, Henriksen T. Dyslipidemia in early second trimester is mainly a feature of women with early onset pre-eclampsia. Br J Obstet Gynaecol. 2001;108:1081–1087. [PubMed]
22. Wladimiroff JW, Van den Elzen HJ, Cohen-Overbeek TE, De Bruijin AJ, Grobbee DE. Serum lipids in early pregnancy and risk of pre-eclampsia. Br J Obstet Gynaecol. 1996;103:117–122. [PubMed]
23. Craig SR, Amin RV, Russell DW, Paradise NF. Blood cholesterol screening influence of fasting state on cholesterol results and management decisions. J Gen Intern Med. 2000;15:395-99. [PubMed]
24. Schaefer EJ, Audelin MC, McNamara JR, et al. Comparison of fasting and postprandial plasma lipoproteins in subjects with and without coronary heart disease. Am J Cardiol. 2001;88:1129-33. [PubMed]
25. Endresen MJ, Lorentzen B, Henriksen T. Increased lipolytic activity and high ratio of free fatty acids to albumin in sera from women with preeclampsia leads to triglyceride accumulation in cultured endothelial cells. Am J Obstet Gynecol. 1992;167:440–447.
26. Sattar N, Greer IA. Pregnancy complications and maternal cardiovascular risk: opportunities for intervention and screening. Br Med J. 2002; 325:157–160.
CITATION
DOI: 10.17511/ijmrr.2013.i02.03
Published: 2013-06-30
How to Cite
1.
Singh U, Yadav S, Mehrotra S, Natu SM, kumari K, Singh Yadav Y. Serum Lipid Profile in Early Pregnancy as a Predictor of Preeclampsia. Int J Med Res Rev [Internet]. 2013Jun.30 [cited 2024May1];1(2):55-2. Available from: https://ijmrr.medresearch.in/index.php/ijmrr/article/view/9
Section
Original Article
OAI - Open Archives Initiative
