Serum Levels of Soluble Fms like Tyrosine Kinase-1(sFlt-1) in Normotensive and Preeclamptic Pregnancy

  • Dr Sonali Yadav Ph.D, Department of Pathology, King George’s Medical University, Lucknow, Uttar Pradesh, India
  • Dr Yogendra Singh M.D, Department of Medicine, King George’s Medical University, Lucknow, Uttar Pradesh, India
  • Dr S.M. Natu Ph.D, Department of Pathology, King George’s Medical University, Lucknow, Uttar Pradesh, India
  • Dr M.M. Goel M.D, Department of Pathology, King George’s Medical University, Lucknow, Uttar Pradesh, India
  • Dr Urmila Singh M.D, Department of Obstetrics and Gynecology, King George’s Medical University, Lucknow, Uttar Pradesh, India
  • Dr Pushpa Tondon Ph.D, Department of Pathology, King George’s Medical University, Lucknow, Uttar Pradesh, India
DOI: https://doi.org/10.17511/ijmrr.2013.i03.07
Keywords: Pregnancy, Preeclampsia, Soluble Fms like Tyrosine Kinase-1

Abstract

Background: The study aimed to measure serum levels of sFlt-1 throughout pregnancy in normotensive and preeclamptic women and to determine if sFlt-1 concentrations alter before the clinical manifestation of the condition.

Material and Methods: It was a nested case control study. Serum samples were collected during pregnancy at three different gestational periods (12-20 weeks, 21-28 weeks and 29- till term) and one sample post delivery, from within the cohort of pregnant women reporting to antenatal clinic. The subjects were divided in to normotensive (controls) and preeclamptic (cases) groups. Circulating levels of antiangiogenic (sFlt-1) were analyzed by enzyme linked immunosorbent assay (ELISA).

Results: Maternal serum concentrations of sFlt-1 increased with the advancement of gestation age in both normotensive and preeclamptic pregnancies but significantly more increased levels were observed in preeclamptic pregnancies as compared with normotensive pregnancies.

Conclusion: Maternal circulating sFlt-1 concentrations were significantly higher in women with preeclampsia, which may contribute to the development of preeclampsia.

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CITATION
DOI: 10.17511/ijmrr.2013.i03.07
Published: 2013-08-31
How to Cite
1.
Yadav S, Singh Y, Natu S, Goel M, Singh U, Tondon P. Serum Levels of Soluble Fms like Tyrosine Kinase-1(sFlt-1) in Normotensive and Preeclamptic Pregnancy. Int J Med Res Rev [Internet]. 2013Aug.31 [cited 2024Apr.18];1(3):114-9. Available from: https://ijmrr.medresearch.in/index.php/ijmrr/article/view/18
Issue
Vol 1 No 3 (2013): Jul-Aug
Section
Original Article

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