Clinical profile of viral hepatitis in a tertiary health care centre of eastern India
Abstract
Background: Viral hepatitis is epidemic to developing country like India. Infection with Hepatitis A virus, Hepatitis B virus and Hepatitis C virus is much more important so far as the disease severity, selection of treatment option and adverse outcome associated with the therapy is concerned. This study was undertaken to assess the clinical and laboratory profile of viral hepatitis with co-infection at a tertiary care centre.
Material and Methods: Patients admitted in the hospital with presenting signs and symptoms of viral hepatitis were included. The clinical and haematological profiles were observed and entered in a pre-designed format. Data were extracted and analysed by one-way-analysis-of-variance (ANOVA) and p < 0.05 was considered statistically significant.
Results: The mean age of the patients was 32.86±13.3 years (range, 18-60 years). Eleven patients were positive for hepatitis-E where as 6 patients were co-infected with both hepatitis-A and hepatitis-E. The commonest presenting symptom was yellowness of eyes and urine that accounts in 19 patients followed by fever in 8 patients, abdominal pain in 5 patients and vomiting in 3 patients. The incidence of dengue and leptospirosis was found in one patient each. Two patients had died.
Conclusion: Large cohort of patients with different hepatitis virus infections is necessary for better understanding of pathophysiology, clinical profile that will enable treatment regimen tools for the patients for single as well as different co-infection.
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References
Suri AD, Jain RK, Jain SC. Study of Jaundice profile in Pregnancy in tertiary care centre in central India. International Journal of Medical Research and Review. 2014; 2 (1): 3-7.https://ijmrr.medresearch.in/index.php/ijmrr/article/view/50.
Sharma RS, Datta KK, Datta M. Field trial on village level surveillance of epidemic prone diseases and its evaluation. Swasth Hind. 1987; 31: 301-303 and 319.
Indrani K, Prasad SP. Shrestha J, Pal SR. Etiological Spectrum of acute sporadic viral hepatitis amongsts adults in Chandigarh. Indian J. Med Res. 1990; 91:91-93. http://www.ijmr.in/CurrentTopicView.aspx?year=Indian%20J%20Med%20Res%2091,%20March%201990,%20pp%2091-93$Original%20Article.
Crespo J, Lozano JL, de la Cruz F et al., Prevalence and significance of hepatitis C viremia in chronic active hepatitis B. American Journal of Gastroenterelogy. 1949; 89 (8):1147-51.
Purcell RH, Emerson SU. Hepatitis E: an emerging awareness of an old disease. J Hepatol 2008:48(3):494-503.doi: https://doi.org/10.1016/j.jhep.2007.12.008.
Khuroo MS. Study of an epidemic of non-A, non-B hepatitis, Possibility of another human hepatitis virus distinct from post-transfusion non-A, non-B hepatitis. Am J Med. 1980; 68: 818-24.doi: https://doi.org/10.1016/0002-9343(80)90200-4.
Viswanathan R. Infectious hepatitis in Delhi (1955-56): a critical study-epidemiology. Indian J Med Res. 1957; 45: 1-29.
Chi-Jen C, Shou-Dong L. Hepatitis B virus/hepatitis C virus co-infection: epidemiology, clinical features, viral interactions and treatment. Journal Gastroenterol Hepatol. 2008; 23(4):512-20.doi: https://doi.org/10.1111/j.1440-1746.2008.05384.x.
Khuroo MS, Rustgi VK, Dawson GJ, et al. Spectrum of hepatitis E virus infection in India. J Med Virol.1994; 43(3):281-6.DOI: https://doi.org/10.1002/jmv.1890430316.
Jabbar A, Pathan M. Clinical Profile of Viral Hepatitis at a Tertiary Care Centre in Rural Maharashtra: An Observational Study. IOSR Journal of Dental and Medical Sciences (IOSR-JDMS). 2015; 14(10): 26-28. https://www.iosrjournals.org/iosr-jdms/papers/Vol14-issue10/Version-7/F0141072628.pdf.
Toshniwal HK. Clinical profile of viral hepatitis – A study of 1569 cases. The Indian Practitioner. 1990; XLIII: 567-573.
Modi TN, Patel SA, Mirani KM, et al. A Study of Clinical Profile and Outcome in Acute Viral Hepatitis E. Indian Journal of Clinical Practice. 2013; 23(10):635-37. http://medind.nic.in/iaa/t13/i3/iaat13i3p635.pdf.
Ziauddin, Ali S, Saeedi MI. Frequency and clinical presentations of hepatitis B and C virus co-infection in tertiary care hospital. Rawal Medical Journal. 2013; 38(1): 11-14.
Boda S, Makineni VM, Chinni AK, et al., Clinical and laboratory profile of hepatitis E during an outbreak in Nellore: A tertiary care centre experience. Int J Sci Stud 2015;3(2):132-138. DOI: 10.17354/ijss/2015/227
Sudhamsu KC. Ultrasound findings in acute viral hepatitis. Kathmandu Univ Med J (KUMJ). 2006; 4:415-8.
Zhang S, Wang J, Yuan Q, et al. Clinical characteristics and risk factors of sporadic Hepatitis E in central China. Virol Journal. 2011; 8: 152. DOI: https://doi.org/10.1186/1743-422X-8-152.
Murthy KAS, Kiran PK, Hakeem H. A study of viral hepatitis E infection in a tertiary care hospital in Mysore, South india. Open forum infectious disease. 2014 Jun 19;1(1):ofu036. doi: https://doi.org/10.1093/ofid/ofu036.
Tong MJ, el-Farra NS, Grew MI. Clinical Manifestations of Hepatitis A: Recent Experience in a Community Teaching Hospital. Journal of infectious disease. 1995;171 suppl 1: S15-8.doi: https://doi.org/10.1093/infdis/171.supplement_1.s15.
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