Prescription Pattern of Anti Microbial Agents in Patients of Appendicitis Admitted in Tertiary care Teaching Hospital: a Cross Sectional Study

  • Dr. Sarang Ghodki Senior Resident, Department of Pharmacology, Dr. Panjabrao Deshmukh Memorial Medical College, Amravati, India
  • Dr Sanjio Borade Senior Resident, Department of Pharmacology, Dr. Panjabrao Deshmukh Memorial Medical College, Amravati, India
  • Dr Ashok Bhore Professor and Head, Department of Pharmacology, Dr. Panjabrao Deshmukh Memorial Medical College, Amravati, India
  • Dr Narayan Umale Professor and Head, Department of Surgery, Dr. Panjabrao Deshmukh Memorial Medical College, Amravati, India
  • Dr Kishor Bansod Associate Professor, Department of Pharmacology, Dr. Panjabrao Deshmukh Memorial Medical College, Amravati, India
  • Dr. Varsha Bijwe Associate Professor, Department of Surgery, Dr. Panjabrao Deshmukh Memorial Medical College, Amravati, India
DOI: https://doi.org/10.17511/ijmrr.2014.i06.02
Keywords: Appendicitis, Rational Use, Antimicrobial agent, Antimicrobial Prescription

Abstract

Introduction: Appendicitis is one of the common conditions which usually require surgical intervention. It is almost always associated with inflammation with bacterial infection, treated either conservatively or surgically. In both situations, different types of antimicrobial agents (AMAs) are used. AMAs are used either in inadequate or over doses. This results in development of antimicrobial resistance in microorganisms and thereby increasing duration of stay, morbidity and cost of treatment.

Objective: To Study the Prescription pattern of AMAs in patients of appendicitis admitted in Surgery ward of tertiary care teaching hospital.

Method: It was a cross sectional study carried out over a period of six months. Data was collected from cases papers of surgery ward from medical record section. It was analyzed and evaluated on basis of various parameters like demographic distribution, complicated or uncomplicated cases, type of treatment, percentage of AMAs prescribed in order of preference, dose, duration, frequency and route of administration of AMAs (i.e. Rational use), average no. of AMAs per patient, incidence of surgical site infection, duration of stay in hospital, etc.

Results: Out of 113 cases of appendicitis, only 33 (29.20%) were treated rationally. Ceftriaxone and cefpodoxime were most frequently used AMAs. Average AMAs prescribed per patient were 3. Average of total durationof stay in hospital was 10 days.

Conclusion: AMA prescription policy should be formulated and displayed in surgery ward for complicated and uncomplicated appendicitis cases to promote / facilitate rational prescription.

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References

1. Walker ARP, Segal I. “What causes appendicitis?” J clinical Gastroenterology 1990; 12:127–129.

2. F.Gregory Connell, Oshkosh. “Etiology of appendicitis.” The American J of Surg 1937;37(2):232–238.

3. Wojciechowicz KH, Hofkamp HJ, van Hulst RA. “Conservative treatment of acute appendicitis. An overview.” International Maritime Health 2010;61(4):189 –272.

4. Hansson J, Ko¨ rner U, Khorram-Manesh A, Solberg A, Lundholm K. “Randomized clinical trial of antibiotic therapy versus appendicectomy as primary treatment of acute appendicitis in unselected patients”, British J of Surg 2009;96:473– 481.

5. Ansaloni L, Catena F, Coccolini F, Ercolani G, Gazzotti F, Pasqualini E, Pinna AD, “Surgery versus conservative antibiotic treatment in acute appendicitis: a systematic review and meta-analysis of randomized controlled trials.” Digestive Surgery 2011;3:210-21.

6. Promoting rational use of medicines: core components, WHO Policy perspectives on Medicines, September 2002 World Health Organization Geneva. Page 1- 6.

7. Krishnakant Dave, Rational drug therapy, Bulletin of the society for rational therapy 1994; 5(1):02-05.

8. Bangari AK, Adiveni T, Manna PK, Mahesh VP, Junior Sundresh N. Studies on antibiotics prescribing pattern in surgical Wards of department of surgery at rajah muthiah Medical college hosipital. World Journal of Pharmacy and Pharmaceutical Sciences 2014;3(7):832-871.

9. Inchien Chamisa. What Is the Role of Conservative Antibiotic Treatment in Early Appendicitis? Appendicitis – A Collection of Essays from Around the World 2012:95-106. www.intechopen.com assessed on 04-05-2014.

10. Luckmann R. Incidence and case fatality rates for acute appendicitis in California: a population-based study of the effects of age. Am J Epidemiol 1989;129:905-209

11. Khan SA, Rao PGM, Rao A, Rodrigues G. Survey and evaluation of antibiotic prophylaxis usage in surgery wards of tertiary level institution before and after the implementation of clinical guidelines. Indian Journal of Surgery 2006;68(3):150 – 156.

12. Colizza S, Picconi A, Blasi G. Monitoring of antimicrobial prophylaxis in general surgery. J. Chemother. 1999; 11:573.6.

13. Bratzler DW, Dellinger EP, Olsen KM, Perl TM, Auwaerter PG, Bolon MK, et al., Clinical practice guidelines for antimicrobial prophylaxis in surgery, Am J Health-Syst Pharm 2013; 70:195-283.

14. Fernández HA, Monge V, Garcinuňo MA. Surgical antibiotic prophylaxis: effect in postoperative infections. Eur J Epidemiol 17:369, 2001.

15. Kasatpibal N, Nørgaard M, Sørensen HT, Schønheyder HC, Jamulitrat S, Chongsuvivatwong V. Risk of surgical site infection and efficacy of antibiotic prophylaxis: a cohort study of appendectomy patients in Thailand, BMC Infectious Diseases 2006, 6:111. http://www.biomedcentral.com/1471-2334/6/111.

16. Josiah Olusegun Alamu, Evaluation of antimicrobial use in a pediatric Intensive care unit, University of Iowa, Iowa Research Online 2009, http://ir.uiowa.edu
CITATION
DOI: 10.17511/ijmrr.2014.i06.02
Published: 2014-12-31
How to Cite
1.
Ghodki S, Borade S, Bhore A, Umale N, Bansod K, Bijwe V. Prescription Pattern of Anti Microbial Agents in Patients of Appendicitis Admitted in Tertiary care Teaching Hospital: a Cross Sectional Study. Int J Med Res Rev [Internet]. 2014Dec.31 [cited 2024Nov.8];2(6):517-23. Available from: https://ijmrr.medresearch.in/index.php/ijmrr/article/view/151
Issue
Vol 2 No 6 (2014): Nov-Dec
Section
Original Article

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