Evaluation of antimicrobial prescription pattern in Neonatal Intensive care unit of tertiary care teaching hospital
Abstract
Introduction: Neonates admitted in Neonatal Intensive Care Units (NICU) have high morbidity and mortality with very subtle and subjective clinical signs. Hence/so Anti Microbial Agents (AMAs), being/become mainstay drugs, are often used empirically and irrationally.
Method: This is cross- sectional study over the period of six months from October 2012 to March 2013. Clinical, hematologic, laboratory, microbiologic and therapeutic data were collected, analyzed and evaluated from the case papers of NICU. Rational use in our study means appropriate dose, duration, frequency and route of administration appropriate to clinical conditions.
Result: Of 118 neonates, 66 (56%) were treated rationally. Approximately 60 % times appropriate dose and frequency of drugs were given. Cefotaxime was most commonly prescribed AMA for neonates (73.73 %). In our study low birth weight neonates have received more antibiotics in comparison with term babies.
Conclusion: AMA prescription policy be formulated and displayed in NICU to promote rational prescription.
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References
2. Schellack N, Gous AGS. Antibiotic prescribing patterns in a neonatal intensive care unit. South Afr J Epidemiol Infect 2011;26(4)(Part II):267-270.
3. Josiah Olusegun Alamu. Evaluation of antimicrobial use in a paediatric Intensive care unit, University of Iowa, Iowa Research Online 2009, http://ir.uiowa.edu assessed on 01-08-2014.
4. Shah MN, Desai PB. Emergence of multi-drug-resistant Klebsiella pneumoniae in Neonatal Intensive Care Units: concern about antimicrobial policies. Research Journal of Recent Sciences 2012;1:275-280.
5. Sheth KV, Patel TK, Tripathi CB. Antibiotic sensitivity pattern in neonatal intensive care unit of a tertiary care hospital of India. Asian Journal of Pharmaceutical and Clinical Research 2012;5(3):46-50.
6. Meyer E, Schwab F, Jonas D. Surveillance of antimicrobial use and antimicrobial resistance in intensive care units (SARI): 1. antimicrobial use in german intensive care units. Intensive Care Med. 2004;30(6):1089-96. [PubMed]
7. Fridkin SK, Steward CD, Edwards JR. Surveillance of antimicrobial use and antimicrobial resistance in United States hospitals: Project ICARE phase 2. Project intensive care antimicrobial resistance epidemiology (ICARE) hospitals. Clin Infect Dis. 1999;29(2):245-52.
8. Dworzack DL, Pugsley MP, Sanders CC. Emergence of resistance in gram negative bacteria during therapy with expanded-spectrum cephalosporins. Eur J Clin Microbiol. 1987;6(4):456-9.[PubMed]
9. Webb CH. Antibiotic resistance associated with selective decontamination of the digestive tract. J Hosp Infect. 1992;22(1):1-5. [PubMed]
10. Yves Liem TB, Krediet TG, Andre´ Fleer, Egberts TCG, Rademaker CMA. Variation in antibiotic use in neonatal intensive care units in the Netherlands. J Antimicrob Chemother 2010;65(6):1270-5.
11. Badar VA, Navale SB. Study of Prescribing Pattern of Antimicrobial Agents in Medicine Intensive Care Unit of a Teaching Hospital in Central India. JAPI 2012; 60:20-23.[PubMed]
12. Tschudy MM, Arcara KM. The Johns Hopkins Hospital, The Harriet Lane Handbook, 19th Ed.2012.[PubMed]
13. Promoting rational use of medicines: core components, WHO Policy Perspectives on Medicines, September 2002 World Health Organization Geneva.
14. Ambwani S, Mathur AK. Rational drug use. Health Administrator. Chapter 2;19(1):5-7.[PubMed]
15. Cloherty J, Etic C, Anne R, Stark AR. A manual of neonatal care. 7th Ed. Wolters Kluwer Health. Lippincott Willians and Wilkins.
16. Peter O, Pharoah D. Outcome Prediction in Greek Neonatal Intensive Care Units. J of American Academy of Paediatrics 1998;101(6):1070. [PubMed]
17. Dorling JS, Field DJ, Manktelow B. Neonatal disease severity scoring systems. Arch Dis Child Fetal Neonatal Ed 2005;90:F11–F16.
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