Precipitating Factors of Psoriasis in North Indian Population

  • Dr. Kamlesh Kumar Bhaskar Consultant, Department of Skin & V.D., District Hospital Gazipur, Uttar Pradesh India
  • Dr. Kavita Chawla Professor of Physiology, MLNMC, Prayagraj, Uttar Pradesh, India
  • Dr. Beenu Professor of Biochemistry, MLNMC, Prayagraj, Uttar Pradesh, India
  • Dr. Archana Mishra Assistant Professor of Biochemistry, MLNMC, Prayagraj, Uttar Pradesh, India
  • Dr. Rakesh Kumar Shukla Assistant Professor of Anatomy, ASMC, Mirzapur, Uttar Pradesh, India
Keywords: Psoriasis, Precipitating factors, Psoriasis plaque, Psoriasis-Arthritis


Aim: This study aims to study precipitating factors of psoriasis in the north Indian population. Material &

Method: Two hundred twenty-eight psoriasis patients regardless of age, sex, religion, occupation, attending the skin, and V.D. outpatients Department, B.R.D. Medical College, Gorakhpur for were taken because of the subject of this study. The bulk of patients belonged to the Eastern U.P. and adjoining areas of Bihar and Nepal. The clinical criteria for diagnosis of psoriasis were the presence of Erythematous and papulosquamous lesions with loosely adherent silvery-white scales. The auspitz's sign was demonstrated all told the cases. The detailed clinical history and examination were recorded. Each patient was categorized into mild to severe psoriasis.

Result: The maximum percentage of cases was aggravated by weather (winter), 55.26%, next to that was trauma 27.1 9%, and least after infections 4.35%. The summer and spring seasons showed an improved effect on the condition of psoriasis. Alcohol, smoking, and mental stress found no relation with psoriasis. In most cases, where the infection was associated with the disease, it had been aggravated only in children, and young adults and lesions were of guttate type. Pregnancy had no effect in 25.43% of cases, while the disease was improved in 3.50% of patients and worsen in 4.35% of cases.

Conclusion: Psoriasis is positively correlated with the winter season and negatively associated with Summer and Spring.


Download data is not yet available.


Wagner EF, Schonthaler HB, Guinea-Viniegra J, Tschachler E. Psoriasis: what we have learned from mouse models. Nat Rev Rheumatol. 2010 Dec;6(12):704-14. doi: 10.1038/nrrheum.2010.157.

Di Cesare A, Di Meglio P, Nestle FO. The IL-23/Th17 axis in the immunopathogenesis of psoriasis. J Invest Dermatol. 2009 Jun;129(6):1339-50. doi: 10.1038/jid.2009.59.

Winchester R, Minevich G, Kane D et al. Heterogeneity of the psoriasis phenotype revealed by H.L.A. class I haplotype associations in psoriatic arthritis and psoriasis. Clin Immunol 2008;127:S88–9

Vena GA, Altomare G, Ayala F, Berardesca E, Calzavara-Pinton P, Chimenti S, et al. Incidence of psoriasis and association with comorbidities in Italy: a 5-year observational study from a national primary care database. Eur J Dermatol. 2010 Sep-Oct;20(5):593-8. doi: 10.1684/ejd.2010.1017.

Mehta NN, Yu Y, Pinnelas R, Krishnamoorthy P, Shin DB, Troxel AB, Gelfand JM. Attributable risk estimate of severe psoriasis on major cardiovascular events. Am J Med. 2011 Aug;124(8):775.e1-6. doi: 10.1016/j.amjmed.2011.03.028.

Griffiths CE, Barker JN. Pathogenesis and clinical features of psoriasis. Lancet. 2007 Jul 21;370(9583):263-271. doi: 10.1016/S0140-6736(07)61128-3.

Diani M, Cozzi C, Altomare G. Heinrich Koebner and His Phenomenon. JAMA Dermatol. 2016 Aug 1;152(8):919. doi: 10.1001/jamadermatol.2015.6015.

Søyland E, Heier I, Rodríguez-Gallego C, Mollnes TE, Johansen FE, Holven KB, et al, Sun exposure induces rapid immunological changes in skin and peripheral blood in patients with psoriasis. Br J Dermatol. 2011 Feb;164(2):344-55. doi: 10.1111/j.1365-2133.2010.10149.x.

Sigurdardottir SL, Thorleifsdottir RH, Valdimarsson H, Johnston A. The association of sore throat and psoriasis might be explained by histologically distinctive tonsils and increased expression of skin-homing molecules by tonsil T cells. Clin Exp Immunol. 2013 Oct;174(1):139-51. doi: 10.1111/cei.12153.

Bernhard, Jeffrey D. "Auspitz sign is not sensitive or specific for psoriasis." Journal of the American Academy of Dermatology 22.6 (1990): 1079-1081.

Hancox JG, Sheridan SC, Feldman SR, Fleischer AB Jr. Seasonal variation of dermatologic disease in the U.S.A.: a study of office visits from 1990 to 1998. Int J Dermatol. 2004 Jan;43(1):6-11. doi: 10.1111/j.1365-4632.2004.01828.x.

Wu Q, Xu Z, Dan YL, Zhao CN, Mao YM, Liu LN, Pan HF. Seasonality and global public interest in psoriasis: an infodemiology study. Postgrad Med J. 2020 Mar;96(1133):139-143. doi: 10.1136/postgradmedj-2019-136766.

Ng CY, Huang YH, Chu CF, Wu TC, Liu SH. Risks for Staphylococcus aureus colonization in patients with psoriasis: a systematic review and meta-analysis. Br J Dermatol. 2017 Oct;177(4):967-977. doi: 10.1111/bjd.15366.

Wei, Shengcai, et al. "Study of the association between HLA-DQA1 alleles and environmental factors in psoriasis." Zhonghua liu xing bing xue za zhi= Zhonghua liuxingbingxue zazhi 23.6 (2002): 445-448.

Naldi L. Psoriasis and smoking: links and risks. Psoriasis (Auckl). 2016 May 27;6:65-71. doi: 10.2147/PTT.S85189.

Richer V, Roubille C, Fleming P, Starnino T, McCourt C, McFarlane A, et al. A Systematic Literature Review and Meta-Analysis With Qualitative Analysis of Effect of Smoking on Psoriasis Severity. J Cutan Med Surg. 2016 May;20(3):221-7. doi: 10.1177/1203475415616073.

Zeng J, Luo S, Huang Y, Lu Q. Critical role of environmental factors in the pathogenesis of psoriasis. J Dermatol. 2017 Aug;44(8):863-872. doi: 10.1111/1346-8138.13806.

Adışen E, Uzun S, Erduran F, Gürer MA. Prevalence of smoking, alcohol consumption and metabolic syndrome in patients with psoriasis. An Bras Dermatol. 2018 Mar;93(2):205-211. doi: 10.1590/abd1806-4841.20186168.

Singh S, Young P, Armstrong AW. Relationship between psoriasis and metabolic syndrome: a systematic review. G Ital Dermatol Venereol. 2016 Dec;151(6):663-677.

Yang YW, Chen CS, Chen YH, Lin HC. Psoriasis and pregnancy outcomes: a nationwide population-based study. J Am Acad Dermatol. 2011 Jan;64(1):71-7. doi: 10.1016/j.jaad.2010.02.005.

Bröms G, Haerskjold A, Granath F, Kieler H, Pedersen L, Berglind IA. Effect of Maternal Psoriasis on Pregnancy and Birth Outcomes: A Population-based Cohort Study from Denmark and Sweden. Acta Derm Venereol. 2018 Aug 29;98(8):728-734. doi: 10.2340/00015555-2923.

Horn EJ, Chambers CD, Menter A, Kimball AB; International Psoriasis Council. Pregnancy outcomes in psoriasis: why do we know so little? J Am Acad Dermatol. 2009 Aug;61(2):e5-8. doi: 10.1016/j.jaad.2009.05.004.

Ding X, Wang T, Shen Y, Wang X, Zhou C, Tian S, et al. Prevalence of psoriasis in China: a population-based study in six cities. Eur J Dermatol. 2012 Sep-Oct;22(5):663-7. doi: 10.1684/ejd.2012.1802.

Marino J, Paster J, Benichou G. Allorecognition by T Lymphocytes and Allograft Rejection. Front Immunol. 2016 Dec 14;7:582. doi: 10.3389/fimmu.2016.00582.

DOI: 10.17511/ijmrr.2021.i05.01
Published: 2021-10-04
How to Cite
Dr. Kamlesh Kumar Bhaskar, Dr. Kavita Chawla, Dr. Beenu, Dr. Archana Mishra, Dr. Rakesh Kumar Shukla. Precipitating Factors of Psoriasis in North Indian Population. Int J Med Res Rev [Internet]. 2021Oct.4 [cited 2021Nov.30];9(5):280-5. Available from:
Original Article

Most read articles by the same author(s)