Role of biochemistry, cytology, and biopsy in the etiological diagnosis of pleural effusion- a clinical study

  • Dr. Manan Bedi Postgraduate Resident, Department of Respiratory Medicine, NIMS, Jaipur, Rajasthan, India
  • Dr. Nalin Joshi Professor, Department of Respiratory Medicine, NIMS, Jaipur, Rajasthan, India
Keywords: Pleural fluid, Pleural biopsy, Tubercular, Malignancy


Introduction:Pleural effusion is the most common pleural disorder. It refers to excessive or abnormal accumulation of fluid in the pleural space. It is a commonly occurring medical problem caused by various pathological conditions. To treat patients appropriately, it is important to establish an accurate etiological diagnosis.

Material and Method: This is an observational study conducted at a tertiary health care center. The pleural effusion was assessed clinically, biochemically, bacteriologically, cytologically, and histopathologically.

Result: Tuberculosis was the most common etiology, followed by malignancy. A pleural biopsy was done in 70 patients. Pleural tissue was obtained in 65 cases. On histopathology,Malignancy was diagnosed in 15, tuberculosis in 35, and non-specific inflammation in 13 cases. Out of 35 histological proven tuberculosis cases, 26 cases had adenosine de-aminase (ADA) more than 70 u/l.

Conclusion:Every pleural effusion is not due to tuberculosis but can be due to other causes, malignancy should always be excluded. Pleural fluid cytology and biopsy can give a definite diagnosis in a significant number of cases of pleural effusion. Tuberculosis is still the most common cause of pleural effusion followed by malignancy.


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How to Cite
Bedi M, Joshi N. Role of biochemistry, cytology, and biopsy in the etiological diagnosis of pleural effusion- a clinical study. Int J Med Res Rev [Internet]. 2020Jun.30 [cited 2020Aug.9];8(3):259-64. Available from:
Original Article