Hypothyroidism in type 2 diabetics – a hospital-based prevalence study

  • Dr. Ravi Kiran Narukurthi Associate Professor, Department of General Medicine, GSL Medical College, Rajahmundry, Andhra Pradesh, India
  • Dr. C (Mandava) Radha Mani Associate Professor, Department of General Medicine, GSL Medical College, Rajahmundry, Andhra Pradesh, India
  • Dr. Deepthi Ala Department of General Medicine, GSL Medical College, Rajahmundry, Andhra Pradesh, India
  • Dr. T Jaya Chandra Scientist Incharge, Central Research Laboratory, GSL Medical College, Rajahmundry, Andhra Pradesh, India
Keywords: Diabetes, Thyroid, Thyroidism, Individual

Abstract

Introduction: Thyroid hormones and insulin are the antagonists and both are involved in cellular metabolism. With this, the study was planned to find the prevalence of thyroid dysfunction in type 2 diabetes mellitus (DM).

Materials and Methods: Study was conducted in the department of General Medicine, GSL Medical College. The study protocol was approved by the institutional ethical committee. All type 2 diabetics aged >30yrs, irrespective of treatment were included in the study. Individuals on metformin therapy, smokers, thyroid hormone users, who underwent thyroid surgery, individuals on radioiodine therapy, pregnant women and individuals on steroids were excluded. Venous blood samples were taken from for fasting blood glucose and 2-hour post glucose blood sugar, glycosylated hemoglobin, lipid profile, and thyroid function estimated measured by using the autoanalyzer. Chi-square test was used to compare differences in categorical variables and p<0.05 was considered statistically significant.

Results: Among 104 participants, 82.7% were euthyroid, 12.5% had subclinical and 4.8% had clinical hypothyroidism; statistically the difference not significant when age/gender was correlated. But there was a significant association with dyslipidemia.

Conclusion: Hypothyroidism is very common among type 2 DM individuals and both complement others' metabolism.

Downloads

Download data is not yet available.

References

Ajaz Ahmad Telwani, Zahid Hussain Wani, Younis Ashraf, Aejaz Ahmad Shah. Prevalence of thyroid dysfunction in type 2 diabetes mellitus: a case control study. Int J Res Med Sci. 2017;5(10):4527-4531. doi: http://dx.doi.org/10.18203/2320-6012.ijrms20174590.

American diabetes association. Diagnosis and classification of diabetes mellitus. Diabetes care. 2010;33(1): 562-569. doi: doi: http://dx.doi.org/10.2337/dc14-S081.

Gray RS, Irvine WJ, Clarke BF. Screening for thyroid dysfunction in diabetics. Br Med J. 1979;2(6202): 1439. doi: https://dx.doi.org/10.1136%2Fbmj.2.6202.1439-a.

Perros P, McCrimmon RJ, Shaw G, Frier BM. Frequency of thyroid dysfunction in diabetic patients: value of annual screening. Diabet Med. 1995;12(7):622-627. doi: https://doi.org/10.1111/j.1464-5491.1995.tb00553.x.

Smithson MJ. Screening for thyroid dysfunction in a community population of diabetic patients. Diabet Med. 1998;15(2):148-150. doi: https://doi.org/10.1002/(SICI)1096-9136(199802)15:2%3C148::AID-DIA540%3E3.0.CO;2-H.

Udiong CEJ, Udoh AE, Etukudoh. Evaluation of thyroid function in diabetes mellitus in Calabar, Nigeria. Ind J Clin Biochem. 2007;22:74-78. doi: https://doi.org/10.1007/BF02913318.

Celani MF, Bonati ME, Stucci N. Prevalence of abnormal thyrotropin concentrations measured by a sensitive assay in patients with Type 2 diabetes mellitus. Diabete Res. 1994;27(1):15-25.

Sugure DD, McEvoy M, Drury MI. Thyroid disease in diabetics. Postgrad Med J. 1999;91(1):680-684. doi: https://dx.doi.org/10.1136%2Fpgmj.58.685.680.

Shah SN. Thyroid disease in diabetes mellitus. J Assoc Physicians India. 1984;32(12):1057-1059.

Papazafiropoulou A, Sotiropoulos A, Kokolaki A, Kardara M, Stamataki P, Pappas S. Prevalence of thyroid dysfunction among Greek type 2 diabetic patients attending an outpatient clinic. J Clin Med Res. 2010;2(2):75- 78. doi: https://doi.org/10.4021/jocmr2010.03.281w.

Chen HS, Wu TE, Jap TS, Lu RA, Wang ML, Chen RL, Lin HD. Subclinical hypothyroidism is a risk factor for nephropathy and cardiovascular diseases in type 2 diabetic patients. Diabet Med. 2007;24(12):1336-1344. doi: https://doi.org/10.1111/j.1464-5491.2007.02270.x.

Demitrost L., Ranabir S. Thyroid dysfunction in type 2 diabetes mellitus: A retrospective study. Indian J Endocrinol Metab 2012;16(2):S334-S335. doi: https://doi.org/10.4103/2230-8210.104080.

Brenta G. Diabetes and thyroid disorders. Brit J Diab Vascul Dis. 2010;10(4):172-177. doi: https://doi.org/10.1177%2F1474651410371321.

Ravishankar SN, Champakamalini, Venkatesh, Mohsin. A prospective study of thyroid dysfunction in patients with Type 2 diabetes in general population. Arch Med. 2013;5(1:2):1-5.

Duntas LH, OrgiazziJ, Brabant G. The interface between thyroid and diabetes mellitus. Clin Endocrinol. 2011;75(1):1-9. doi: https://doi.org/10.1111/j.1365-2265.2011.04029.x.

Nobre EL, Jorge Z, Pratas S, Silva C, Castro JJ. Profile of the thyroid function in a population with type 2 diabetes mellitus. Proceed Joint Brit Endocrine Soc. 2002: 298.

Vij V, Chitnis P, Gupta V.K. Evaluation of Thyroid Dysfunction among Type 2 Diabetic patients. Int J Pharma Biol Sci. 2012;2(4):150-155.

Khandelwal, Tandon. Overt and subclinical hypothyroidism, who to treat and how, department of endocrinology and metabolism, All India Institute of Medical Sciences, New Delhi, India. Drugs. 2012;72(1):17-33. doi: https://doi.org/10.2165/11598070-000000000-00000.

Wang C. The relationship between type 2 diabetes mellitus and related thyroid diseases. J Diabetes Res.2013;10:1-12. doi: https://dx.doi.org/10.1155%2F2013%2F390534.

Keyur Brahme, Jaydeep Devaliya, Ishani Haldar, Mahendra Parmar, Kalpita Shringarpure. Does the glycemic control and duration of diabetes affect Thyroid Dysfunction? A cross-sectional study from a tertiary hospital in Central Gujarat. Sch J App. Med Sci. 2016;4(8D):3031-3036. doi: https://dx.doi.org/10.21276/sjams.2016.4.8.57.

G.A. Mohamed, A.M Elsayed. Subclinical hypothyroidism ups the risk of vascular complications in type 2 diabetes. Alexandria J Med. 2017;53(3):285-288.

Mouradian M, Abourizk N. Diabetes mellitus and thyroid disease. Diabetes Care. 1983;6(5):512-520. doi: https://doi.org/10.2337/diacare.6.5.512.

Brenta G. A View of Diabetes from the Thyroid Corner. Thyroid Int. 2011;3: 3-11.

Published
2020-02-29
How to Cite
1.
Narukurthi RK, Radha Mani DC (Mandava), Ala D, Chandra TJ. Hypothyroidism in type 2 diabetics – a hospital-based prevalence study. Int J Med Res Rev [Internet]. 2020Feb.29 [cited 2020Apr.7];8(1):105-9. Available from: https://ijmrr.medresearch.in/index.php/ijmrr/article/view/1152
Section
Original Article

Most read articles by the same author(s)