Renal functions in patients with metabolic syndrome

  • Dr. Asha Augusthy Associate Professor, Department of Biochemistry, Sree Narayana Institute of Medical Sciences, Ernakulam, Kerala, India
  • Dr. Suchanda Sahu Associate Professor, Department of Biochemistry, All India Institute of Medical Sciences, Sijua, Bhubaneshwar, Odisha, India
  • Dr. Ashok Kumar Jeppu Associate Professor, Biochemistry unit, International Medical School, Management and Science University, Shah Alam, Selangor, Malaysia
  • Dr. Seema Jawalekar Professor, Department of Biochemistry, GMC, Pali, Rajasthan, India
Keywords: eGFR, Metabolic syndrome, Renal function

Abstract

Introduction: Metabolic syndrome consists of a constellation of metabolic abnormalities that confer increased risk of diabetes mellitus. The aim of the present study was to study renal functions in patients with metabolic syndrome.

Materials and methods: 50 controls and 50 individuals with metabolic syndrome were selected by purposive sampling technique. Waist circumference and blood pressure was measured and serum levels of fasting blood sugar, triglycerides and HDL were estimated and eGFR was calculated in controls and cases.

Results: We found that serum urea andcreatininelevels were significantly increased andeGFR levels were significantly decreased in metabolic syndrome when compared to controls.

Conclusion: Our study concluded that there is significant renal dysfunction in patients with metabolic syndrome.

Downloads

Download data is not yet available.

References

Augusthy A, Sahu S, Ashok Kumar J, Jawalekar S, Marakala V, Thattil A. A comparison of BMI and Lipid Profile inpatients with metabolic syndrome and Type 2 Diabetes Mellitus. Int J Med Res Rev 2017;5(03):357-362.doi: http://doi.org/10.17511/ijmrr.2017.i03.23.

Chen J, Muntner P, Hamm LL, et al. The metabolic syndrome and chronic kidney disease in U.S. adults. Ann Intern Med. 2004 Feb 3;140(3):167-74.

Kurella M, Lo JC, Chertow GM. Metabolic syndrome and the risk for chronic kidney disease among nondiabetic adults. J Am Soc Nephrol. 2005 Jul;16(7):2134-40. Epub 2005 May 18.DOI: https://doi.org/10.1681/ASN.2005010106.

Chen J, Gu D, Chen CS, et al. Association between the metabolic syndrome and chronic kidney disease in Chinese adults. Nephrol Dial Transplant. 2007 Apr;22(4):1100-6. Epub 2007 Feb 1.DOI: https://doi.org/10.1093/ndt/gfl759.

Luk AO, So WY, Ma RC, et al. Metabolic syndrome predicts new onset of chronic kidney disease in 5,829 patients with type 2 diabetes: a 5-year prospective analysis of the Hong Kong Diabetes Registry. Diabetes Care. 2008 Dec;31(12):2357-61. doi: https://doi.org/10.2337/dc08-0971. Epub 2008 Oct 3.

Johns BR,PaoAC,Kim SH.Metabolic syndrome, insulin resistance and kidney function in non-diabetic individuals.Nephrol Dial Transplant. 2012 ; 27(4): 1410–1415.doi: https://doi.org/10.1093/ndt/gfr498.

Grundy SM. Metabolic syndrome scientific statement by the American Heart Association and the National Heart, Lung, and Blood Institute. ArteriosclerThrombVasc Biol. 2005 Nov;25(11):2243-4. DOI: https://doi.org/10.1161/01.ATV.0000189155.75833.c7

Maric C, Hall JE. Obesity, metabolic syndrome and diabetic nephropathy. ContribNephrol. 2011;170:28-35. doi: https://doi.org/10.1159/000324941. Epub 2011 Jun 9.

Sheen YJ, Sheu WH. Metabolic syndrome and renal injury. Cardiol Res Pract. 2011 Mar 13;2011:567389. doi: https://doi.org/10.4061/2011/567389.

Huang PL. A comprehensive definition for metabolic syndrome. Dis Model Mech. 2009 May-Jun;2(5-6):231-7. doi: https://doi.org/10.1242/dmm.001180.

Lin C, Li C, Liu Cet al.Risks of Decreased Renal Function and Increased Albuminuria for Glycemic Status and Metabolic Syndrome Components: Taichung Community Health Study.BioMedResearch International. 2014;Article ID 841497.doi: https://doi.org/10.1155/2014/841497.

Delanaye P,Cohen EP. Formula-Based Estimates of the GFR:Equations Variable and UncertainNephron ClinPract. 2008;110:c48–c54.DOI: https://doi.org/10.1159/000151436.

Zaman SB. Detection of Chronic Kidney Disease by Using Different Equations of Glomerular Filtration Rate in Patients with Type 2 Diabetes Mellitus: A Cross-Sectional Analysis.Cureus. 2017 Jun 14;9(6):e1352. doi: https://dx.doi.org/10.7759%2Fcureus.1352.

Augusthy A, Jeppu AK, Sahu S, Jawalekar S, Marakala V, Iqbal S. A study of liver functions in metabolic syndrome and Type 2 diabetes mellitus. Int J Med Res Rev 2016;4(4):470-475. doi: http://doi.org/10.17511/ijmrr.2016.i04.01.

Zoccali C, Mallamaci F. Adiponectin and leptin in chronic kidney disease: causal factors or mere risk markers? J Ren Nutr. 2011 Jan;21(1):87-91. doi: http://doi.org/10.1053/j.jrn.2010.10.014.

Gelber RP, Kurth T, Kausz AT, et al. Association between body mass index and CKD in apparently healthy men. Am J Kidney Dis. 2005 Nov;46(5):871-80.

Thomas G, Sehgal AR, Kashyap SR, et al. Metabolic syndrome and kidney disease: a systematic review and meta-analysis. Clin J Am Soc Nephrol. 2011 Oct;6(10):2364-73. doi: https://doi.org/10.2215/CJN.02180311. Epub 2011 Aug 18.

Pinto-Sietsma SJ, Navis G, Janssen WM, et al. A central body fat distribution is related to renal function impairment, even in lean subjects. Am J Kidney Dis. 2003 Apr;41(4):733-41.

Bagby SP. Obesity-initiated metabolic syndrome and the kidney: a recipe for chronic kidney disease? J Am Soc Nephrol. 2004 Nov;15(11):2775-91. DOI: https://doi.org/10.1097/01.ASN.0000141965.28037.EE.

Rashidi A, Ghanbarian A, Azizi F. Are patients who have metabolic syndrome without diabetes at risk for developing chronic kidney disease? Evidence based on data from a large cohort screening population. Clin J Am Soc Nephrol. 2007 Sep;2(5):976-83. Epub 2007 Aug 8.DOI: https://doi.org/10.2215/CJN.01020207.

Sun F, Tao Q, Zhan S. Metabolic syndrome and the development of chronic kidney disease among 118 924 non-diabetic Taiwanese in a retrospective cohort. Nephrology (Carlton). 2010 Feb;15(1):84-92. doi: https://doi.org/10.1111/j.1440-1797.2009.01150.x.

Evangelista LS, Cho WK, Kim Y. Obesity and chronic kidney disease: A population-based study among South Koreans. PLoS One. 2018 Feb 28;13(2):e0193559. doi: https://dx.doi.org/10.1371%2Fjournal.pone.0193559. eCollection 2018.

Stenvinkel P, Zoccali C, Ikizler TA. Obesity in CKD--what should nephrologists know? J Am Soc Nephrol. 2013 Nov;24(11):1727-36. doi: https://doi.org/10.1681/ASN.2013040330. Epub 2013 Oct 10.

Kang YU, Kim HY, Choi JS, Kim CS, Bae EH, Ma SK, et al. Metabolic Syndrome and Chronic Kidney Disease in an Adult Korean Population: Results from the Korean National Health Screening. PLoS ONE .2014;9(5): e93795. doi: https://doi.org/10.1371/journal.pone.0093795.

Mikolasevic I, Žutelija M, Mavrinac V, et al. Dyslipidemia in patients with chronic kidney disease: etiology and management. Int J NephrolRenovasc Dis. 2017 Feb 7;10:35-45. doi: https://dx.doi.org/10.2147%2FIJNRD.S101808. eCollection 2017.

Weiner DE, Sarnak MJ. Managing dyslipidemia in chronic kidney disease. J Gen Intern Med. 2004 Oct;19(10):1045-52.

McMahon GM, Preis SR, Hwang SJ, et al. Mid-adulthood risk factor profiles for CKD. J Am Soc Nephrol. 2014 Nov;25(11):2633-41. doi: https://doi.org/10.1681/ASN.2013070750. Epub 2014 Jun 26.

Kebapci N, Uslu S, Ozcelik E. Metabolic syndrome is a risk factor for the development of chronic renal disease. Ren Fail. 2013;35(4):460-5. doi: https://doi.org/10.3109/0886022X.2013.774680. Epub 2013 Mar 18.

Renal functions in patients with metabolic syndrome
CITATION
DOI: 10.17511/ijmrr.2018.i08.02
Published: 2018-12-31
How to Cite
1.
Augusthy A, Sahu S, Kumar Jeppu A, Jawalekar S. Renal functions in patients with metabolic syndrome. Int J Med Res Rev [Internet]. 2018Dec.31 [cited 2024Apr.26];6(8):403-8. Available from: https://ijmrr.medresearch.in/index.php/ijmrr/article/view/1011
Section
Original Article

Most read articles by the same author(s)