Acute Urinary Retention: A Rare Presentation in Acute Myeloid Leukemia
Keywords:
Acute myeloid leukemia, hyperleukocytosis, leukostasis, Urinary retention
Abstract
Hyperleukocytosis is defined when the total leukocyte count is more than 100000/cmm. Leukostasis occurs in hyperleukocytic acute myeloid leukemia when the numbers of blasts are very high. Leukostasis causes impaired normal functioning of vascular systems because of crowding of blasts in its microvasculature or in its vessels supplying the nerves. Leukostasis causes early deaths in acute myeloid leukemia (AML) due to involvement of central nervous system and lungs. Acute retention of urine because of haematological causes is rarely seen. Dysfunction of bladder because of leukostasis in hyperleukocytic AML is warning. Cytoreduction therapy in hyperleukocytic AML prevents early deaths.
Downloads
Download data is not yet available.
References
1. Porcu P, Farag S, Marcucci G, Cataland SR, Kennedy MS, Bissell M. Leukocytoreduction for acute leukemia. Ther Apher 2002; 6:15–23. [PubMed]
2. Lichtman MA . Classification and clinical manifestations of clonal myeloid disorders .In: Kaushansky K, Lichtman MA, Beutler E, Kipps TJ, Seligsohn U, Prchal JT, editors. Williams Hematology .8th ed, US: Mc Graw -Hill and company; 2010: p. 1211-23.
3. Ganzel C, Becker J, Mintz PD, Lazarus HM, Rowe JM. Hyperleukocytosis, leukostasis and leukapheresis: practice management. Blood Rev. 2012 May; 26(3): 117-22. [PubMed]
4. Porcu P, Cripe LD, Ng EW, Bhatia S, Danielson CM, Orazi A, Mc Carthy LJ. Hyperleukocytic leukemias and leukostasis: a review of pathophysiology, clinical presentation and management. Leuk Lymphoma. 2000; 39:1-18. [PubMed]
5. Majhail NS, Lichtin A. Acute leukemia with a very high leukocyte count: Confronting a medical emergency. Cleveland Clinic Journal of Medicine, 2004; 71(8): 633-7. [PubMed]
6. Marbello L, Ricci F, Nosari AM , Turrini M ,Nador G , Nichelatti M ,Tedeschi A ,Vismara E ,Morra E. Outcome of hyperleukocytic adult acute myeloid leukaemia: a single-center retrospective study and review of literature .Leuk Res. 2008 Aug;32(8):1221-7.
7. Bug G, Anargyrou K, Tonn T, Bialleck H, Seifried E, Hoelzer D, Ottmann OG. Impact of leukapheresis on early death rate in adult acute myeloid leukemia presenting with hyperleukocytosis. Transfusion 2007 Oct;47(10):1843-50.
2. Lichtman MA . Classification and clinical manifestations of clonal myeloid disorders .In: Kaushansky K, Lichtman MA, Beutler E, Kipps TJ, Seligsohn U, Prchal JT, editors. Williams Hematology .8th ed, US: Mc Graw -Hill and company; 2010: p. 1211-23.
3. Ganzel C, Becker J, Mintz PD, Lazarus HM, Rowe JM. Hyperleukocytosis, leukostasis and leukapheresis: practice management. Blood Rev. 2012 May; 26(3): 117-22. [PubMed]
4. Porcu P, Cripe LD, Ng EW, Bhatia S, Danielson CM, Orazi A, Mc Carthy LJ. Hyperleukocytic leukemias and leukostasis: a review of pathophysiology, clinical presentation and management. Leuk Lymphoma. 2000; 39:1-18. [PubMed]
5. Majhail NS, Lichtin A. Acute leukemia with a very high leukocyte count: Confronting a medical emergency. Cleveland Clinic Journal of Medicine, 2004; 71(8): 633-7. [PubMed]
6. Marbello L, Ricci F, Nosari AM , Turrini M ,Nador G , Nichelatti M ,Tedeschi A ,Vismara E ,Morra E. Outcome of hyperleukocytic adult acute myeloid leukaemia: a single-center retrospective study and review of literature .Leuk Res. 2008 Aug;32(8):1221-7.
7. Bug G, Anargyrou K, Tonn T, Bialleck H, Seifried E, Hoelzer D, Ottmann OG. Impact of leukapheresis on early death rate in adult acute myeloid leukemia presenting with hyperleukocytosis. Transfusion 2007 Oct;47(10):1843-50.
CITATION
DOI: 10.17511/ijmrr.2014.i03.18
Published: 2014-06-30
How to Cite
1.
Barik S, Sinha S. Acute Urinary Retention: A Rare Presentation in Acute Myeloid Leukemia. Int J Med Res Rev [Internet]. 2014Jun.30 [cited 2024Dec.27];2(3):267-9. Available from: https://ijmrr.medresearch.in/index.php/ijmrr/article/view/101
Section
Case Report