Lung function tests in different phases of menstrual cycle
Abstract
Introduction: Menstrual cycle is an integral part of a woman’s life. During these different phases, rhythmic changes occur in the levels of ovarian hormones especially progesterone and estrogen. The goal of this study was to study the effect of the luteal and follicular phases of the menstrual cycle on bronchial reactivity (BR) in a group of women.
Material and Methods: The fifty girl medical students of first year MBBS of 18 – 24 years age were undertaken to study pulmonary function tests in different phases of menstrual cycle. Pulmonary function tests were taken between 8 – 10 th day of menstrual cycle, that is in follicular phase and again were recorded between 20 – 22 nd day of menstrual cycle that is in luteal phase by using spirometric technique. The results were expressed as Mean ± Standard Deviation (Mean+ SD). Statistical analysis was done through Graph pad prism. Comparison of pulmonary function parameters in different phases of menstrual cycle was done by using one way ANOVA (Analysis of Variance) by bonferroni post-hoc test.
Results: Anthropometric measurement of all subjects in which mean age was 19.45 ± 1.80 years, arm span was 157.25± 6.37 cm, chest circumference was 80.58 ± 7.69 cm , height was 149.07 ±4.64 cm , weight was 45.65±6.69 Kgs. Spirometric study found FVC , FEV1, and PEFR increase in luteal phase of menstrual cycle compared to follicular phase, which were statistically significant.
Conclusion: We found better lung functions which were statistically significant in luteal phase as compared to follicular phase of our subjects indicating a possible role of progesterone causing β adrenergic stimulation / sensitization.
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