Effect of parenteral vitamin D (D3) on albuminuria in T2DM patients
Abstract
Background: Vitamin D deficiency is a common disorder in diabetic patients and may be a risk factor for progression of diabetic nephropathy. The aim of our study was to assess the effects of large dose of parentral Vitamin D on 24 hours albuminuria in T2DM patients. This is a first study of its kind, where we used single large dose parental vitamin D.
Methods: This prospective single center study included 50 vitamin D deficient [25(OH) D <50 nmol/l] T2DM patients with an adequate glycemic control (HbA1c< 7.0%). Without any changes in anti-hyperglycemic or antihypertensive drugs, these patients were given a single high dose (600000 IU) of parenteral Vitamin D3. Then the changes in Vitamin D levels and 24 hours albuminuria were seen on follow up at 3 months.
Results: Vitamin D3 supplementation improved 24 hrs albuminuria. In this study twenty-four hour urinary albumin excretion decreased from 200.4 ± 103.3 to 198.4 ± 105.0 mg/24 hrs (p value 0.015). In males it changed from 212.1 ± 95.4 to 209.6 ± 96.9 (p value 0.046) and in females it changed from 188.6 ± 111.3 to 186.8 ± 112.9. (P value 0.041) .There was a negative association of albuminuria with Vit D levels in our study with p value =0.001 at 3 months of follow up.
Conclusion: Vitamin D3 supplementation significantly reduces 24 hour urinary albumin excretion in T2DM patients with Vitamin D3 deficiency.
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References
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