Role of C- reactive protein in diabetic retinopathy

  • Dr Dsouza May Father Muller Medical College, Mangalore, Karnataka, India
  • Dr Rodrigues Francis EA Father Muller Medical College, Mangalore, Karnataka, India
  • Dr Mendonca Norman Father Muller Medical College, Mangalore, Karnataka, India
  • Dr Nazareth Nelly DO DNB, Father Muller Medical College, Mangalore, India
  • Dr Dsouza Nameeth FVRS, KS Hegde Medical Academy, Mangalore, Karnataka, India
  • Dr Shah Amish J Aravind Eye Hospital, Madurai, India
Keywords: Diabetic retinopathy, C- reactive protein, Pathogenesis, Diabetes mellitus, PDR, CSME

Abstract

Introduction: Diabetes mellitus is a major medical problem throughout the world. Diabetes causes an array of long-term systemic complications that have considerable impact on the patient as well as society, as the disease typically affects individuals in their most productive years. C Reactive Protein is an acute phase reactant and an inflammatory mediator involved in the pathogenesis of Diabetic Retinopathy.

Aim: The aim of this study is to determine the correlation of C-reactive protein with diabetic retinopathy and different grades of retinopathy.

Methods: The study was done on 200 diabetic patients attending the ophthalmology outpatient department, who were selected by purposive sampling. The patients were subjected to a complete ocular examination. Based on the fundus examination patients were categorized into the respective study groups: - 1) Controls 2) Diabetics without Diabetic Retinopathy 3) NPDR 4) PDR 5) CSME. The patients were then subjected to C- reactive protein estimation via laboratory analysis (Turbidometry Technique).

Results: The study showed that the mean CRP levels in diabetics were found to be 3mg/dl which is well within normal limits. The CRP levels were relatively higher in the PDR and CSME groups with it being elevated in 30% and 20% patients in the groups respectively.

Conclusion: CRP levels in our study did not show significant correlation with diabetes mellitus. Although higher grades of retinopathy had higher CRP levels, the correlation was not significant and consistent. Hence C- reactive protein cannot be used as a reliable screening tool for diabetic retinopathy.

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Role of C- reactive protein in diabetic retinopathy
CITATION
DOI: 10.17511/ijmrr.2017.i06.07
Published: 2017-06-30
How to Cite
1.
Dsouza M, Francis EA R, 3Dr Mendonca NormanM, Nelly DO N, Dsouza N, Shah AJ. Role of C- reactive protein in diabetic retinopathy. Int J Med Res Rev [Internet]. 2017Jun.30 [cited 2024Mar.28];5(6):585-92. Available from: https://ijmrr.medresearch.in/index.php/ijmrr/article/view/884
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Original Article