Acute Pancreatitis-A Prospective study of Estimation of Prognosis with MCTSI versus CTSI
Abstract
Introduction: CT is the imaging method of choice for assessing the extent of acute pancreatitis and for evaluating complications. This study was conducted to assess the correlation of modified CT Severity Index (MCTSI) with patient outcome in cases of acute pancreatitis (AP) and to compare it with the CT Severity Index (CTSI).
Material and methods: A prospective study of 62 cases was carried out in the Department of Radio Diagnosis, with complaint suggestive of acute pancreatitis on the basis of clinical/laboratory/ultrasonography findings/who were referred for a CECT evaluation of the abdomen and pelvis. The severity of the attack was evaluated using both the indices CT and MCTSI. Correlation between the severity of pancreatitis and the outcome parameters was calculated using the chi square test.
Results: When using MCTSI, there was significant correlation between the severity of AP and the outcome parameters such as length of hospital stay (p<0.001), occurrence of infection (p<0.001) and organ failure (p<0.001). CTSI correlated significantly with the occurrence of end organ failure (p = 0.009) and infection (p=0.042) but less so than MCTSI. In case of intervention, the CTSI (p<0.001) fared slightly better than MCTSI (p=0.001). There was no significant correlation between the severity of Acute Pancreatitis as assessed by the CTSI and the duration of hospitalization (p=0. 160).
Conclusion: The MCTSI correlates significantly with the patient outcome parameters than the CTSI and thus can be useful in predicting the prognosis in patients with acute pancreatitis at an early stage.
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References
Banday IA, Gattoo I, Khan AM, Javeed J, Gupta G, Latief M. Modified Computed Tomography Severity Index for Evaluation of Acute Pancreatitis and its Correlation with Clinical Outcome: A Tertiary Care Hospital Based Observational Study. J Clin Diagn Res. 2015 Aug;9(8):TC01-5.doi: https://dx.doi.org/10.7860%2FJCDR%2F2015%2F14824.6368. Epub 2015 Aug 1.
Manfredi R, Brizi MG, Canadè A, Vecchioli A, Marano P. Imaging of acute pancreatitis. Rays. 2001 Apr-Jun;26(2):135-42.
Mortelé KJ, Mergo PJ, Taylor HM, Wiesner W, Cantisani V, Ernst MD, Kalantari BN, Ros PR. Peripancreatic vascular abnormalities complicating acute pancreatitis: contrast-enhanced helical CT findings. Eur J Radiol. 2004 Oct;52(1):67-72.
Han J, Kim HG, Jung MK, Cho CM, Cho K, Kim KH, et al. Revised Atlanta classification of acute pancreatitis can predict clinical outcome better: a retrospective, multicenter study. Pancreatology. 2014;14(3):S32.
Raghuwanshi S,Gupta R.CT Evaluation of Acute Pancreatitis and its Prognostic Correlation with CT Severity Index J ClinDiagn Res. 2016 Jun; 10(6): TC06–TC11. Published online 2016 Jun 1.
Banks PA, Bollen TL, Dervenis C, Gooszen HG, Johnson CD, Sarr MG, Tsiotos GG, Vege SS; Acute Pancreatitis Classification Working Group. Classification of acute pancreatitis--2012: revision of the Atlanta classification and definitions by international consensus. Gut. 2013 Jan;62(1):102-11. doi: http://dx.doi.org/10.1136/gutjnl-2012-302779. Epub 2012 Oct 25.
Baig SJ, Rahed A, Sen S.A prospective study of the aetiology, severity and outcome of acute pancreatitis in Eastern India.TropGastroenterol. 2008 Jan-Mar;29(1):20-22.
Mortele KJ, Wiesner W, Intriere L, et al: A Modified CT Severity Index for evaluating acute pancreatitis: Improved correlation with patient outcome. AJR 2004;183:1261-1265.
Bollen TL, Singh VK, Maurer R, Repas K, van Es HW, Banks PA, Mortele KJ. Comparative evaluation of the modified CT severity index and CT severity index in assessing severity of acute pancreatitis. AJR Am J Roentgenol. 2011 Aug;197(2):386-92. doi: https://doi.org/10.2214/AJR.09.4025.
Yadav D, Lowenfels AB. The epidemiology of pancreatitis and pancreatic cancer. Gastroenterology. 2013 Jun;144(6):1252-61. doi: https://doi.org/10.1053/j.gastro.2013.01.068.
Banday IA, Gattoo I, Khan AM, Javeed J, Gupta G, Latief M.Modified Computed Tomography Severity Index for Evaluation of Acute Pancreatitis and its Correlation with Clinical Outcome: A Tertiary Care Hospital Based Observational Study. J ClinDiagn Res. 2015 Aug; 9(8):TC01-5.
Melkundi S, Anand N. Modified computed tomography severity index in acute pancreatitis. Journal of Evolution of Medical and Dental Sciences. 2014;3(74):15541–51.h
Shyu JY, Sainani NI, Sahni VA, Chick JF, Chauhan NR, Conwell DL, Clancy TE, Banks PA, Silverman SG. Necrotizing pancreatitis: diagnosis, imaging, and intervention. Radiographics. 2014 Sep-Oct;34(5):1218-39. doi: https://doi.org/10.1148/rg.345130012.
Lankisch PG, Struckmann K, Assmus C, Lehnick D, Maisonneuve P, Lowenfels AB ScandDo we need a computed tomography examination in all patients with acute pancreatitis within 72 h after admission to hospital for the detection of pancreatic necrosis? J Gastroenterol. 2001 Apr; 36(4):432-6.
Wiesner W, Studler U, Kocher T, Degen L, Buitrago-Tellez CH, Steinbrich W. Colonic involvement in non-necrotizing acute pancreatitis: correlation of CT findings with the clinical course of affected patients. Eur Radiol. 2003 Apr;13(4):897-902. Epub 2002 Jun 28.
Chamisa I, Mokoena T, Luvhengo TE. Changing Pattern of Incidence, Aaetiology and Mortality from Acute Pancreatitis at Kalafong Hospital, Pretoria, South Africa, 1988-2007: A Retrospective Evaluation. East and Central African Journal of Surgery. 2010;15(1):35–39.
Mortelé KJ, Mergo PJ, Taylor HM, Ernst MD, Ros PR. Renal and perirenal space involvement in acute pancreatitis: spiral CT findings. Abdom Imaging. 2000 May-Jun;25(3):272-8.
Lecesne R, Taourel P, Bret PM, Atri M, Reinhold C. Acute pancreatitis: interobserver agreement and correlation of CT and MR cholangiopancreatography with outcome. Radiology. 1999 Jun;211(3):727-35.
Sharmaa V, Surinder S. Ranaa A study of radiological scoring system evaluating extrapancreatic inflammation with conventional radiological and clinical scores in predicting outcomes in acute pancreatitis Ann Gastroenterol 2015; 28 (1): 1-6. http://www.annalsgastro.gr
Chenyang Chen, MD, Zixing Huang Evaluation of extrapancreatic inflammation on abdominal computed tomography as an early predictor of organ failure in acute pancreatitis as defined by the revised Atlanta classification Medicine (Baltimore). 2017 Apr; 96(15): e6517.Published online 2017 Apr 14.