Methotrexate Induced Toxic Epidermal Necrolysis: A Case Report

  • Dr. S. Bhuvaneshwari T. Shanmugham Med. Pharmacology, Assistant Professor, Department of Pharmacology, Andaman Nicobar Islands Institute of Medical Sciences (ANIIMS), Port Blair, India
  • Dr. C.Dinesh M. Naidu Professor Head, Department of Pharmacology, Andaman Nicobar Islands Institute of Medical Sciences (ANIIMS), Port Blair, India
  • Dr. Vinay Raghuvanshi Senior Resident, Department of Pharmacology, Andaman Nicobar Islands Institute of Medical Sciences (ANIIMS), Port Blair, India
Keywords: Methotrexate, Necrolysis, skin, Psoriasis, Toxicity

Abstract

Methotrexate continues to be one of the most widely used systemic immunosuppressive agents in dermatology. We describe a case of low-dose methotrexate (MTX) toxicity in a patient with chronic plaque psoriasis occurring during long-standing methotrexate therapy. This case report emphasizes the fact that co-medications like NSAIDS may exacerbate MTX toxicity. This patient had a rare methotrexate-induced toxic epidermal necrolysis including cutaneous ulceration. Hence, careful consideration of concomitant medication is required to avoid drug interactions for safe long-term methotrexate treatment.

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References

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Methotrexate Induced Toxic Epidermal Necrolysis: A Case Report
CITATION
DOI: 10.17511/ijmrr.2017.i05.09
Published: 2017-05-31
How to Cite
1.
T. Shanmugham SB, M. Naidu C, Raghuvanshi V. Methotrexate Induced Toxic Epidermal Necrolysis: A Case Report. Int J Med Res Rev [Internet]. 2017May31 [cited 2024Mar.28];5(5):492-4. Available from: https://ijmrr.medresearch.in/index.php/ijmrr/article/view/876
Section
Case Report