Altered PTEN expression as a diagnostic marker for the earliest endometrial precancerous changes

  • Dr. Bela Sharda PG Resident, Department of Pathology, Gandhi Medical College, Bhopal, Madhya Pradesh, India
  • Dr. Reeni Malik Professor and Head of Department, Department of Pathology, Gandhi Medical College, Bhopal, Madhya Pradesh, India
  • Dr. Pramila Jain Associate Professor, Department of Pathology, Gandhi Medical College, Bhopal, Madhya Pradesh, India
Keywords: PTEN, Endometrial hyperplasia, Endometrial carcinoma

Abstract

Introduction: Study was planned to investigate PTEN gene expression in endometrial hyperplasia and carcinoma as analyzed by immunohistochemistry.

Material and Method: This study was conducted on 80 endometrial samples in the Department of Pathology, Gandhi Medical College, Bhopal (January 2012 to August 2016)

Results: 5 out of 5 cases of proliferative endometrium, 3 out of 5 cases of secretory endometrium, 37 [84%] out of 44 cases of simple and complex endometrial hyperplasia without atypia, 8 out of 15 cases of simple and complex endometrial hyperplasia with atypia and 3 out of 11 cases of endometrial carcinoma showed positive PTEN expression.

Conclusion: PTEN is a major gene involved in the pathogenesis of endometrial carcinoma. Our data suggest that decreased PTEN expression was a marker of earliest endometrial pre-cancer lesion and we propose that use of PTEN immunostaining in a clinical setting may be informative in identifying premalignant lesions that are likely to progress to carcinoma.

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Altered PTEN expression as a diagnostic marker for the earliest endometrial precancerous changes
CITATION
DOI: 10.17511/ijmrr.2017.i05.13
Published: 2017-05-31
How to Cite
1.
Sharda B, Malik R, Jain P. Altered PTEN expression as a diagnostic marker for the earliest endometrial precancerous changes. Int J Med Res Rev [Internet]. 2017May31 [cited 2024Mar.28];5(5):515-23. Available from: https://ijmrr.medresearch.in/index.php/ijmrr/article/view/873
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