Spectrum of abnormal epithelial lesions of cervix in a tertiary care teaching hospital in South India
Abstract
Introduction: Cervical cancer is the leading cause of death in developing countries like India. Cervical cytology by papanicolaou (pap) smears is an effective means of screening for cervical premalignant and malignant lesions.
Aim: To study the role of pap smear in detecting premalignant and malignant lesions of cervix and to determine the prevalence of various lesions.
Materials and Methods: This was a retrospective study of 1030 conventional pap smears reported from the Department of Pathology, Government Medical College, Anantapuramu. The time period was from October 2014 – September 2016.
Results: In our study out of 1030 cases, inflammatory smears were reported in 713 cases (69.22%), Epithelial cell abnormalities were found in 71 smears(6.89%), atypical squamous cells of undetermined significance (ASCUS) in 27 (2.62%), AGUS in 0.10%, LSIL in 25 cases (2.43%), HSIL in 1.26% cases and invasive squamous cell carcinoma in 5 (0.48%) cases.
Downloads
References
Rathore SB, Atal R. Study of Cervical Pap Smears in a Tertiary Hospital. International Journal of Science and research(IJSR). 2016;5(5): 2071-2074.
Bamanikar SA, Baravkar DS, Chandanwale SS, dapkekar P. Study of Cervical Pap Smears in a Tertiary Hospital. Indian Medical Gazette. 2014:250-254. DOI: http://dx.doi.org/10.18203/2320-6012.ijrms20160044.
Bal MS, Goyal R, Suri AK, Mohi MK. Detection of abnormal cervical cytology in Papanicolaou smears. Journal of cytology. 2012 Jan 1;29(1):45-7.DOI: https://dx.doi.org/10.4103%2F0970-9371.93222.
Jena A, Bharathi T, Siva Kumar Reddy YK, Manilal B, Patnayak R, Phaneendra BV. Papanicolaou (Pap) test screening of staff members of a tertiary care teaching hospital in south India. J.Clin Sci. Res.,2012;1:174-7.
Bhojani KR, Garg R. Cytopathological study of cervical smears and correlation of findings with risk factors. Int J Biol Med Res. 2011;2(3):757-61.
Vaghela B, Vaghela VK, Santwani PM. Profile of PAP smear cytology and its histopathological correlation at tertiary care center–A retrospective study. International Journal of Biomedical and Advance Research. 2014 Jan 30;5(1):47-9. DOI: https://doi.org/10.7439/ijbar.v5i1.551
Bhattacharya AB, Agarwal A, Dwivedi AD, Khan S, Das R, Bohara S, Sharma R. Uterine Cervical Smear Patterns In Females Attending A Teaching Hospital In Rural Eastern Uttar Pradesh, INDIA. IOSR Journal of Dental and Medical Sciences (IOSR-JDMS).2016;1(15):45-9. DOI: https://doi.org/10.9790/0853-1509024549.
Dr. Rupal P. Mehta, Dr. Alpa Shah, Dr. T. Y. Vijapura, Dr. Himanshu P. Patel Study of Epithelial Abnormalities in Cervical Smear of Perimenopausal and Postmenopausal Women. International Journal of Scientific Research.2013; 2(7):326-28. DOI: https://doi.org/10.15373/22778179.
Diane Solomon; Diane Davey; Robert Kurman; et al. The 2001 Bethesda System: Terminology for Reporting Results of Cervical Cytology. JAMA. 2002;287(16):2114-2119. doi: https://doi.org/10.1001/jama.287.16.2114
Thirumurugan P, Premila E, Suresh kanna K. Study of early detection of cervical cancer by pap’s smear in selected setting of puducherry. Asia pacific journal of research.2015;1(34):156-160.
Mufti ST, Altaf FJ. Changing pattern of epithelial cell abnormalities using revised Bethesda system. Iranian Journal of Basic Medical Sciences. 2014;17(10):779-784.
Proca DM, Rofagha S, Keyhani-Rofagha S. High grade squamous intraepithelial lesion in inmates from Ohio : Cervical screening and biopsy follow-up. CytoJournal 2006;3:15. DOI: https://dx.doi.org/10.1186%2F1742-6413-3-15.
Thomas C. Wright, Jr. Pathology of HPV infection at the cytologic and histologic levels: Basis for a 2-tiered morphologic classification system. International Journal of Gynecology and Obstetrics (2006) 94 (Supplement 1), S22-S3.
Rubia Noreen, Huma Qudussi.‘Pap smear’ for screening of precancerous conditions of cervix.J Ayub Med Coll Abbottabad 2011;23(2) 41-4.
Balaha MH, Al Moghannum MS, Al Ghowinem N, Al Omran S. Cytological pattern of cervical papanicolaou smear in eastern region of Saudi Arabia. J Cytol 2011;28:173-7.DOI: http://www.jcytol.org/text.asp?2011/28/4/173/86343.
Nandwani RR, Totade S, Krishnan MG. Cytomorphological evaluation of squamous cell abnormalities observed on cervical smears in government medical college, Jabalpur, India: a five year study. Int J Res Med Sci 2016;4(3):794-9.DOI: http://dx.doi.org/10.18203/2320-6012.ijrms20160520.
Kalyani R, Sharief N, Shariff S. A study of Pap smear in a Tertiary Hospital in south India. J Cancer Biol Res .2016;4(3):1084.
Mandakini M Patel, Amrish N Pandya, Jigna Modi . Cervical Pap smear study and its utility in cancer screening, to specify the strategy for cervical cancer control. National Journal of community medicine,2011;2(1):49-51.
Tejeswini V, Premalatha P. Pap smear examination-its utility in various cervical lesions. Indian Journal of Pathology and Oncology. 2016;3(2):242-6.