Pulmonary hypertension before and after balloon mitral Valvuloplasty
Abstract
Objective: To testify effectiveness of BMV in mitral stenosis to resolve pulmonary hypertension.
Material and Method: The study was conducted at N.R.S Medical College and Hospital over 18 months with 39 patients of severe mitral stenosis with pulmonary hypertension. They were followed up at 48hours, 1 month and 6 month after BMV.
Result: 20.51% patients had mild, 41.02% patients had moderate and 38.46% patients had severe pulmonary hypertension before BMV. Mean mitral valve area before and after BMV were 0.89±0.11cm and 1.89±0.21cm respectively. Mean transmitral gradient was 15.43±2.3mm 0f Hg before and 7. 86±2.25 mm of Hg after BMV. On 3rd day, before discharge PASP became normal in 1 patient in mild group although improvement was not statistically significant (p=0.234) but statistically significant improvement of PSBP was seen in both moderate and severe groups (p=0.001). At 1m follow up PASP came down to normal in 3 patients of mild group (p=0.106). 5 of moderate and 1 patient of severe groups also improved to have PSBP ˂25 mm of Hg, the finding was statistically significant in both groups (p=0.001). The improvement in all three groups at final check up at 6m was statistically significant (p=0.001). 5 patients in each mild and moderate and 2 in severe group were found to have normal PASP.
Conclusion: In spite of significant risk, BMV is worth doing in patients with pulmonary hypertension due to mitral stenosis as there is not only dramatic relief of PH of cardiac causes but also improvement of PH due to pulmonary pathology to some extent.
Downloads
References
Vallerie V, McLaughlin and Marc Humbert. Pulmonary Hypertension. BRAUNWALDS HEART DISEASE. 10th Ed. Elsevier Saunders;2015. 1682-1755.
Barst RJ, Rubin LJ. Pulmonary Hypertension. HURSTS THE HEART. 13th Ed. McGrow Hill 2011. 71: 1609-1633.
Simonneau G, Gatzoulis MA, Adatia I, Celermajer D, Denton C, Ghofrani A, Gomez Sanchez MA, Krishna Kumar R, Landzberg M, Machado RF, Olschewski H, Robbins IM, Souza R. Updated clinical classification of pulmonary hypertension. J Am Coll Cardiol. 2013 Dec 24;62(25 Suppl):D34-41. doi: https://doi.org/10.1016/j.jacc.2013.10.029.
Sinha| K, TNN | Apr 23, 2012.
Rheumatic fever and rheumatic heart disease : report of a WHO Expert Consultation, Geneva, 29 October — 1 November 2001.
Githang'a D. Rheumatic heart disease. East Afr Med J. 1999 Nov;76(11):599-600.
Joint WHO/ISFC meeting on RF/RHD control with emphasis on primary prevention, Geneva, 7–9 September 1994. Geneva, World Health Organization, 1994 (document WHO/CVD 94.1).
Manjunath C.N., Srinivas P, Ravindranath K.S., and Dhanalakshmi C. Incidence and patterns of valvular heart disease in a tertiary care high-volume cardiac center: A single center experience. Indian Heart J. 2014 May; 66(3): 320–326.
Iung B, Cormier B, Ducimetiére P, et al. Immediate results of percutaneous mitral commissurotomy. A predictive model on a series of 1514 patients. Circulation 1996;94:2124–30.
Iung B, Cormier B, Ducimetiére P, et al. Functional results 5 years after successful percutaneous mitral commissurotomy in a series of 528 patients and analysis of predictive factors. J Am Coll Cardiol 1996;27:407–14.
Hildick-Smith DJR, Taylor GJ, Shapiro LM. Inoue balloon mitral valvuloplasty: long-term clinical and echocardiographic follow-up of a predominantly unfavourable population. Eur Heart J 2000;21:1690–7.
Prendergast BD, Shaw TR, Iung B, Vahanian A, Northridge DB. Contemporary criteria for the selection of patients for percutaneous balloon mitral valvuloplasty. Heart. 2002 May;87(5):401-4.
The Criteria Committee of New York Heart Association.(1994). Nomenclature and Criteria for diagnosis of Diseases of the Heart and Great Vessels. (9th Ed.). Boston: Little Brown & Co. pp. 253-256.
Umesan CV, Kapoor A, Sinha N, Kumar MS, Goel PK. Effect of balloon mitral valvotomy on severe pulmonary arterial hypertension in 315 patients with rheumatic mitral stenosis: Immediate and long term results. J Heart Valve Dis 2000 sep; 9(5): 609-15.
Dalen JE, Matloff JM, Evans GL, Hoppin FG Jr, Bhardwaj P, Harken DE, Dexter L. Early reduction of pulmonary vascular resistance after mitral-valve replacement. N Engl J Med. 1967; 277: 387–394.
Carabello BA. Modern management of mitral stenosis. Circulation. 2005 Jul 19;112(3):432-7.
Funjan MM, Msayer K H, Taha Z M. Hemodynamic factors determining immediate response of left atrial pressure reduction attributed to balloon mitral valvotomy. Journal of Al-Nahrain University September 2010; Vol.13 (3):88-98.
John S, Bashi VV, Jairaj PS, Muralidharan S, Ravikumar E, Rajarajeswari T, Krishnaswami S, Sukumar IP, Rao PS. Closed mitral valvotomy: early results and long-term follow-up of 3724 consecutive patients. Circulation. 1983 Nov;68(5):891-6.
Fawzy ME, Hassan W, Stefadouros M, Moursi M, El Shaer F, Chaudhary MA. Prevalence and fate of severe pulmonary hypertension in 559 patients with severe mitral stenosis undergoing mitral balloon valvotomy. J Heart Valve Dis 2004;13:942–8.
Dev V, Shrivastava S. Time course of changes in pulmonary vascular resistance and mechanism of regression of pulmonary artery hypertension after balloon valvotomy. Am J Cardiol 1991;67:439–42.
Mohamed Eid Fawzy. Mitral balloon valvotomy, long-term results, its impact on severe pulmonary hypertension, tricuspid regurgitation, atrial fibrillation, left atrial size, left ventricular function. The Egyptian Heart J 2014 june; 66(2):133-138. Doi: https://doi.org/10.1016/j.ehj.2013.11.002.