Platelet indices in diabetics and influence of glycemic control – a hospital based study in North-East India

  • Dr. Prasun Bhattacharjee Registrar, Department of Medicine, Agartala Govt. Medical College & GB Pant Hospital, Agartala, Tripura, India
  • Dr. Abhijit Datta Associate Professor, Department of Pathology, Agartala Govt. Medical College & GB Pant Hospital, Agartala, Tripura, India
  • Dr. Rajesh Kishore Debbarma Associate Professor, Department of Medicine, Agartala Govt. Medical College & GB Pant Hospital, Agartala, Tripura, India
  • Dr. Swapan Kumar Das Assistant Professor, Department of Medicine, Agartala Govt. Medical College & GB Pant Hospital, Agartala, Tripura, India
Keywords: Glycosylated haemoglobin, Mean platelet volume, Platelet distribution width, Platelet indices, platelet large cell ratio

Abstract

Introduction: Platelets from patients with type 1 and type 2 diabetes exhibit enhanced platelet aggregation activity early in the disease course that may precede the development of cardiovascular diseases. Both atherosclerosis and thrombosis appear to contribute significantly to the increased cardiovascular risk of diabetic patients. Platelet indices include mean platelet volume (MPV), platelet distribution width (PDW), and platelet large cell ratio (P-LCR). This study was undertaken with the aim to find out the differences in platelet indices between diabetics and non-diabetics and also between patients with controlled and uncontrolled diabetes mellitus in a tertiary health care centre in North East India.

Methods: This is a cross sectional study conducted in Agartala Government Medical College and GB Pant Hospital (AGMC & GBP Hospital). 100 cases and 100 controls were selected from the Diabetes clinic of Medicine out patient department (OPD) and Medicine wards. Platelet indices and HbA1C levels of these cases and controls were measured. Platelet indices were measured by a 3-part differential hematology auto-analyzer and HbA1C by High Performance Liquid Chromatography (HPLC) method. Blood glucose levels were estimated by oxidase-peroxidase method.

Results: Platelet indices were found to be significantly higher among diabetics compared to non-diabetics and also they were found higher among patients with poor glycemic control with HbA1C>7% in comparison to patients with good glycemic control with HbA1C<7% (P value <0.05).

Conclusions: Platelet indices are significantly increased in diabetics and the extent of increment is more in diabetics with poor glycemic control.

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References

Longo, Fauci, Kasper, Hauser, Jameson, Loscalzo. Harrison,s Principles of internal medicine. 18th edition. New York: McGraw-Hill Professional;2015.

Nathan DM. Long-term complications of diabetes mellitus. N Engl J Med. 1993 Jun 10;328(23):1676-85. DOI: https://doi.org/10.1056/NEJM199306103282306.

Stamler J, Vaccaro O, Neaton JD, Wentworth D. Diabetes, other risk factors, and 12-yr cardiovascular mortality for men screened in the Multiple Risk Factor Intervention Trial. Diabetes Care. 1993 Feb; 16 (2):434–44.doi: https://doi.org/10.2337/diacare.16.2.434.

Brand FN, Abbott RD, Kannel WB. Diabetes, intermittent claudication, and risk of cardiovascular events.Diabetes. 1989 April; 38(4):504–9.doi: https://doi.org/10.2337/diab.38.4.504.

Reaven GM: Banting Lecture 1988: Role of insulin resistance in human disease. Diabetes. 1988 Dec; 37 (12):1595–1607.doi: https://doi.org/10.2337/diab.37.12.1595.

Pahor M, Psaty BM, Furberg CD. New evidence on the prevention of cardiovascular events in hypertensive patients with type 2 diabetes.J CardiovascPharmacol. 1998; 32 (2) (Suppl. 2):18–23.doi: https://doi.org/10.1097/00005344-199800004-00004.

Halushka PV, Rogers RC, Loadholt CB, Colwell JA. Increased platelet thromboxane synthesis in diabetes mellitus. J Lab Clin Med. 1981 Jan; 97 (1):87–96.

Sagel J, Colwell JA, Crook L, Laimins M. Increased platelet aggregation in early diabetes mellitus. Ann Intern Med.1975 June ;82 (6) :733–8.doi: https://doi.org/10.7326/0003-4819-82-6-733.

Mandal S, Sarode R, Dash S, Dash RJ. Hyperaggregation of platelets detected by whole blood platelet aggregometry in newly diagnosed noninsulin-dependent diabetes mellitus. Am J Clin Pathol. 1993 Aug;100 (2):103–7.doi: https://doi.org/10.1093/ajcp/100.2.103.

Jokl R, Colwell JA: Arterial thrombosis and atherosclerosis in diabetes. Diabetes Metab Rev1997; 5:1–15.

Jokl R, Colwell JA. Clotting disorders in diabetes.In International Textbook of Diabetes Mellitus. 2nd ed. Alberti KGMM, Zimmet P, DeFronzo RA, Keen H, Eds. Chichester, U.K., Wiley, 1997, p. 1543–57.

Schneider DJ. Factors contributing to increased platelet reactivity in people in people with diabetes. Diabetes care. 2009 April ;32(4):525-7.doi: https://dx.doi.org/10.2337%2Fdc08-1865.

Tavil Y, Sen N, Yazici HU. Mean platelet volume in patients with metabolic syndrome and its relationship with coronary artery disease. Thromb Res 2007; 120:24550.doi: https://doi.org/10.1016/j.thromres.2006.10.005.

Khandekar MM, Khurana AS, Deshmukh SD. Platelet volume indices in patients with coronary artery disease and acute myocardial infarction: an Indian scenario. J ClinPathol. 2006 Feb; 59 (2):146-9.doi: https://doi.org/10.1136/jcp.2004.025387.

Kiliçli-Camur N, Demirtunç R, Konuralp C, Eskiser A, BaşaranY. Could mean platelet volume be a predictive marker for acute myocardial infarction? Med SciMonit. 2005; 11:CR387-92.

Nadar SK, Lip GY, Blann AD. Platelet morphology, soluble Pselectin and platelet P-selectin in acute ischaemic stroke.The West Birmingham Stroke Project.ThrombHaemost 2004; 92 (1):1342-8.doi: https://doi.org/10.1160/th04-07-0433.

McCabe DJ, Harrison P, Sidhu PS, Brown MM, Machin SJ. Circulatingreticulated platelets in the early and late phases after ischaemicstrokeand transient ischaemic attack. Br J Haematol.2004; 126:861-9.doi: https://doi.org/10.1111/j.1365-2141.2004.05137.x.

O’Malley T, Langhorne P, Elton RA, Stewart C. Platelet size in stroke patients. Stroke 1995; 26:995-9.doi: https://doi.org/10.1161/01.str.26.6.995.

Bock G, Dalla Man C, Campioni M. Pathogenesis of pre-diabetes: mechanisms of fasting and postprandial hyperglycemia in people with impaired fasting glucose and/or impaired glucose tolerance. Diabetes2006; 55 (2):3536-49.doi: https://doi.org/10.2337/db06-0319.

Papanas N, Symeonidis G, Maltezos E. Mean platelet volume in patients with type2 diabetes mellitus. Platelets 2004; 15 (1):475-8.doi: https://doi.org/10.1080/0953710042000267707.

Hekimsoy Z, Payzin B, Ornek T, Kandoğan G. Mean platelet volume in Type 2 diabetic patients. J Diabetes Complications 2004;18 (1):173-6.doi: https://doi.org/10.1016/s1056-8727(02)00282-9.

Yenigün EC, Okyay GU, Pirpir A, Hondur A, Yıldırım IS. Increased mean platelet volume in type 2 diabetes mellitus. Dicle Medical Journal. 2014; 41 (1): 17-22.doi: https://doi.org/10.5798/diclemedj.0921.2014.01.0366.

Kodiatte TA, Manikyam UK, Rao SB, Jagadish et al. Mean Platelet Volume in type 2 Diabetes Mellitus. J Lab Physicians 2012;vol 4:p5-9.doi: https://doi.org/10.4103/0974-2727.98662.

Jindal S, Gupta S, Gupta R, Kakkar A, Singh HV, Gupta K et al. Platelet indices in diabetes mellitus: indicators of diabetic microvascular complications. Hematology. 2011 Mar;16(2):86-9.doi: https://doi.org/10.1179/102453311x12902908412110.

Akinsegun A, Olusola DA, Sarah JO, Olajumoke O, Adewumi A, Majeed O , Anthonia O, Ebele U, Olaitan O, Olanrewaju A and Kingsley A. Mean platelet volume and platelet counts in type 2 Diabetes: Mellitus on treatment and non-diabetic mellitus controls in Lagos, Nigeria.The Pan African Medical Journal. 2014;18:42. doi: https://www.dx.doi.org/10.11604/pamj.12/05/2014.18.42.3651.

Platelet indices in diabetics and influence of glycemic control – a hospital based study in North-East India
CITATION
DOI: 10.17511/ijmrr.2016.i12.18
Published: 2016-12-31
How to Cite
1.
Bhattacharjee P, Datta A, Kishore Debbarma R, Kumar Das S. Platelet indices in diabetics and influence of glycemic control – a hospital based study in North-East India. Int J Med Res Rev [Internet]. 2016Dec.31 [cited 2021Jun.19];4(12):2186-92. Available from: https://ijmrr.medresearch.in/index.php/ijmrr/article/view/786
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