Verrucous Carcinoma of Vulva: An Unusual Case Report
Keywords:
Verrucous, Carcinoma, Vulva, HPV 6, HPV 8
Abstract
Introduction: Verrucous carcinoma of the vulva is a variant of squamous cell carcinoma and is a rare type of vulvar cancer, consisting 1-2 % of vulvar cancer overall .It is locally invasive and rarely metastasize. The aetiology is not known.
Case report: A 60 year old postmenopausal, multipara Indian woman presented in July 2012 with anexophytic irregular growth that was locally destructive associated with vulvar itching, pain and change in skin colour in the OPD of Obstetrics and Gynaecology department of NIMS Medical College, Jaipur (Rajasthan), India. She was a chronic smoker. Local examination shows 5-6 cm raised verrucous growth on the lower part of right labia majora with 1 cm ulcer at tip. Complete evaluation revealed verrucous carcinoma of vulva FIGO stage IB with no lymph node involvement. The patient was treated with an extensive excision of the damage and radiotherapy was advised.
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References
1. Japaze H, Dinh TV, Woodruff JD, Verrucous carcinoma of the vulva: study of 24 cases. Obstetrics and Gynecology, 1982;60(4):462–466. [PubMed]
2. Kraus FT, Perezmesa C. Verrucous carcinoma-Clinical and pathologic study of 105 cases involving oral cavity, larynx and genitalia. Cancer.1966;19(1):26–38.
3. Shear M,Pindborg JJ. Verrucoushyperplasia of the oral mucosa. Cancer. 1980; 46(8):1855–1862. [PubMed]
4. Siegel R, Ma J, Zou Z, Jemal A. Cancer Statistics2014. CA:Cancer J Clin. 2014;64(1):9-29. [PubMed]
5. Kondi PA, Deligeorgi PH, Liapis A, et al.Human papillomavirus in verrucous carcinoma of vulva:an immune pathological study of three cases. Eur J GynaecolObstet 1998;19:319-320. [PubMed]
6. GualcoM,BoninS,FogliaG,etal.Morphological and biologic studies on ten cases of verrucous carcinoma of the vulva supporting the theory of a discrete clinicopathologicentity.Int J Gynecol Cancer. 2003;13:317-324. [PubMed]
7. Boutas I, Sofoudis C, Kalampokas E, Anastasopoulos C, etal. Verrucous Carcinoma of the Vulva: A Case Report. Case Reports in Obstetrics and Gynecology.2013;2013:3-5. [PubMed]
8. Crowther ME, Shepherd JH, Fisher C.Verrucous carcinoma of the vulva containing human papillomavirus-11. Case report. British Journal of Obstetrics and Gynaecology.1988;95(4):414–418.
9. Ansink A. Vulvar squamous cell carcinoma. SeminDermatol 1996;15:51. [PubMed]
10. Madsen BS, Jensen HL, van den Brule AJ. Risk factors for invasive squamous cell carcinoma of the vulva and vagina--population-based case-control study in Denmark. Int J Cancer 2008; 122:2827.
11. DeKoning MN, Quint WG, Pirog EC. Prevalence of mucosal and cutaneous human papillomaviruses in different histologic subtypes of vulvar carcinoma. Mod Pathol 2008; 21:334.
12. Monk BJ, Burger RA, Lin F, et al. Prognostic significance of human papillomavirus DNA in vulvar carcinoma. Obstetrics Gynecology 1995; 85:709. [PubMed]
13. Insinga RP, Liaw KL, Johnson LG, Madeleine MM. A systematic review of the prevalence and attribution of human papillomavirus types among cervical, vaginal, and vulvar precancers and cancers in the United States. Cancer Epidemiol Biomarkers Prev 2008; 17:1611.
14. S. Gallousis. Verrucous carcinoma: Report of three vulvar cases and review of the literature. Obstetrics and Gynecology.1972; 40(4):502–507.
15. Chu QD, Vezeridis MP, Libbey NP, Wanebo HJ. Giant condylomaacuminatum (Buschke-Lowenstein tumour) of the anorectal and perianal regions: analysis of 42 cases. Diseases of the Colon and Rectum. 1994; 37(9):950–957.
16. Bjørge T, Dillner J, Anttila T et al. Prospective seroepidemiological study of role of human papillomavirus in non-cervical anogenital cancers. British Medical Journal.1997; 315(7109):646–649.
17. Demian SDE, Bushkin FL, Echevarria RA. Perineural invasion and anaplastic transformation of verrucous carcinoma. Cancer.1973; 32(2):395–401. [PubMed]
18. Proffitt SD, Spooner TR, Kosek JC. Origin of undifferentiated neoplasm from verrucous epidermal carcinoma of oral cavity following irradiation. Cancer. 1970; 26(2):389–393.
19. Zaino RJ, Nucci M, Kurman RJ. Diseases of the vagina. Blaustein’s Pathology of the Female Genital Tract.Springer, New York, USA, 2011; 317.
20. Isaacs JH.Verrucous carcinoma of the female genital tract. Gynecologic Oncology.1976; 4(3):259–269.
2. Kraus FT, Perezmesa C. Verrucous carcinoma-Clinical and pathologic study of 105 cases involving oral cavity, larynx and genitalia. Cancer.1966;19(1):26–38.
3. Shear M,Pindborg JJ. Verrucoushyperplasia of the oral mucosa. Cancer. 1980; 46(8):1855–1862. [PubMed]
4. Siegel R, Ma J, Zou Z, Jemal A. Cancer Statistics2014. CA:Cancer J Clin. 2014;64(1):9-29. [PubMed]
5. Kondi PA, Deligeorgi PH, Liapis A, et al.Human papillomavirus in verrucous carcinoma of vulva:an immune pathological study of three cases. Eur J GynaecolObstet 1998;19:319-320. [PubMed]
6. GualcoM,BoninS,FogliaG,etal.Morphological and biologic studies on ten cases of verrucous carcinoma of the vulva supporting the theory of a discrete clinicopathologicentity.Int J Gynecol Cancer. 2003;13:317-324. [PubMed]
7. Boutas I, Sofoudis C, Kalampokas E, Anastasopoulos C, etal. Verrucous Carcinoma of the Vulva: A Case Report. Case Reports in Obstetrics and Gynecology.2013;2013:3-5. [PubMed]
8. Crowther ME, Shepherd JH, Fisher C.Verrucous carcinoma of the vulva containing human papillomavirus-11. Case report. British Journal of Obstetrics and Gynaecology.1988;95(4):414–418.
9. Ansink A. Vulvar squamous cell carcinoma. SeminDermatol 1996;15:51. [PubMed]
10. Madsen BS, Jensen HL, van den Brule AJ. Risk factors for invasive squamous cell carcinoma of the vulva and vagina--population-based case-control study in Denmark. Int J Cancer 2008; 122:2827.
11. DeKoning MN, Quint WG, Pirog EC. Prevalence of mucosal and cutaneous human papillomaviruses in different histologic subtypes of vulvar carcinoma. Mod Pathol 2008; 21:334.
12. Monk BJ, Burger RA, Lin F, et al. Prognostic significance of human papillomavirus DNA in vulvar carcinoma. Obstetrics Gynecology 1995; 85:709. [PubMed]
13. Insinga RP, Liaw KL, Johnson LG, Madeleine MM. A systematic review of the prevalence and attribution of human papillomavirus types among cervical, vaginal, and vulvar precancers and cancers in the United States. Cancer Epidemiol Biomarkers Prev 2008; 17:1611.
14. S. Gallousis. Verrucous carcinoma: Report of three vulvar cases and review of the literature. Obstetrics and Gynecology.1972; 40(4):502–507.
15. Chu QD, Vezeridis MP, Libbey NP, Wanebo HJ. Giant condylomaacuminatum (Buschke-Lowenstein tumour) of the anorectal and perianal regions: analysis of 42 cases. Diseases of the Colon and Rectum. 1994; 37(9):950–957.
16. Bjørge T, Dillner J, Anttila T et al. Prospective seroepidemiological study of role of human papillomavirus in non-cervical anogenital cancers. British Medical Journal.1997; 315(7109):646–649.
17. Demian SDE, Bushkin FL, Echevarria RA. Perineural invasion and anaplastic transformation of verrucous carcinoma. Cancer.1973; 32(2):395–401. [PubMed]
18. Proffitt SD, Spooner TR, Kosek JC. Origin of undifferentiated neoplasm from verrucous epidermal carcinoma of oral cavity following irradiation. Cancer. 1970; 26(2):389–393.
19. Zaino RJ, Nucci M, Kurman RJ. Diseases of the vagina. Blaustein’s Pathology of the Female Genital Tract.Springer, New York, USA, 2011; 317.
20. Isaacs JH.Verrucous carcinoma of the female genital tract. Gynecologic Oncology.1976; 4(3):259–269.
CITATION
DOI: 10.17511/ijmrr.2014.i02.14
Published: 2014-04-30
How to Cite
1.
Patel J, Masand D. Verrucous Carcinoma of Vulva: An Unusual Case Report. Int J Med Res Rev [Internet]. 2014Apr.30 [cited 2024Dec.28];2(2):153-5. Available from: https://ijmrr.medresearch.in/index.php/ijmrr/article/view/77
Section
Case Report
OAI - Open Archives Initiative
