Smoking and its association with serum lipid levels

  • Dr. Devendra Pratap Singh Rajput Associate Professor Medicine, L. N. Medical College, Bhopal, MP, India
  • Dr. Divyani Gulati M.B.B.S. Intern, L.N. Medical College, Bhopal, MP, India
  • Dr. Priti Singh Assistant Professor, Ophthalmology, Gandhi Medical College, Bhopal, MP, India
Keywords: Smoking, Total cholesterol, LDL, VLDL, Triglyceride, HDL

Abstract

Objective: To compare the effect of smoking over lipid profile.

Method: Total 100 subjects were included in this study, 50 were smoker and 50 non-smoker. All the factors other then smoking those can lead to dyslipidemia were ruled out. All patient’s fasting blood sample was collected and lipid profile was estimated. Data was analysed and‘t’ value was calculated.

Results: Serum levels of total cholesterol (TC), triglycerides (TG), low density cholesterol (LDL), very low density cholesterol (VLDL) were found to be significantly high in smokers in comparison to non-smokers but high density cholesterol (HDL) did not any significant difference between two groups.

Conclusion: Smoking affects lipid profile significantly, number and duration of smoking having correlation with serum lipoprotein levels but type of smoking (cigarette or biddi) doesn’t change the outcome.

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References

Prabhat Jha, Binu Jacob,Vandhana Gajalakshmi, Prakash C. Gupta, Neeraj Dhingra, Rajesh Kumar et al.A nationally representative case control study of smoking and death in India NEJM 2008; 358(11): 1137-47.

McGill HC Jr. Potential mechanism for augmentation of atherosclerosis and atherosclerotic disease by cigarette smoking. Prev Med 1979; 8(3): 390-403.

Topping DL. effects of tobacco smoke and its constituents on lipid carbohydrate metabolism. In: Clemens MJ, Ashwell M, eds. Biochemistry of cellular regulation. vol 2. Boca Raton, Florida: CRC Press, 1980: 165-83.

Carlson LA, Bottiger LE, Ahfeldt PE. Risk factors for myocardial infarction in Stockholm prospective study: A 14 year follow up on focusing on the role of plasma triglyceride and cholesterol. Acta Med Scand 1979; 206(5): 315-60.

Ole D. Mjos MD. Lipid effect of smoking. AM heart J 1988; 115(1): 272-5.

Rustogi R, Shrivastava SS, Mehrotra TN, Singh VS, Gupta MK. Lipid profile in smokers. JAPI 1989; 37(12) 764-6.

Austin MA. Plasma triglyceride and coronary heart disease. Arterio Throm 1991; 11(1): 2-14.

Muscat JE, Harris RE, Haley JE, Wynder JE. Cigarette smoking and plasma cholesterol. AM Heart J 1991; 121(1): 141-7.

Hossein Fakhrzadeh, Ozra Tabatabaei-Malazy. Dyslipidemia and cardiovascular disease. ISBN 2012: 978-953-307-904-2.

Nelson Fausto, Vinay Kumar, jon c.Aster, Ann Abbas. Robbins and Cotran pathologic basis of disease.8th edition.2012:1144-1145.

Craig WY, Palomaki GE, HaddowJE: cigarette smoking and serum lipid and lipoprotein concentration: an analysis of published data.BMJ 1989; 298(6676): 784-8.

Simons LA, Simons J, Jones AS. The interaction of body weight, age, cigarette smoking and hormone usage with blood pressure and plasma lipids in an Australian community. Aus NZ Med 1984; 14(3): 215-21.

Benouwitz NL. Pharmacologic aspect of cigarette smoking and nicotine addiction. New Engl J Med 1998; 319(20): 1318-30.

Stalder M, Pometta B, Suenram A. Relationship between plasma insulin levels and HDL-Cholestrol in healthy men. Diabtologia 1981; 21(6): 544-8.

Reaven GM. Role of insulin resistance in human disease. Diabetes. 1988; 37(12): 1595-1607.

Wynder EL, Hariss. Population screening for plasma cholesterol. Community based results from Connecticut. Am Heart J 1989; 117(3): 649-56.

Anila jaleel,Farhan Jaleel, Rahan Majeed and Ejaz Alam. Leptin and bllod lipidlevels in smokers and ex-smokers.world applied sciences journal 2007;2(4) : 348-352.

Zhang Yan-Ling, , Zhan Dong-Quing, Huang Chag-Quan and Dong Bi-Rong. Cigarette smoking and its association with serum lipid/lipoprotein among Chinese nonagenarians/centenarians. Lipids in health and disease 2012;11(1):1-6.

NS Neki.Lipid profile in chronic smokers. JIACM 2002; 3(1): 51-4.

Gepner AD, Piper ME, Johnson HM, Fiore MC, Baker TB, Stein JH. Effects of smoking and smoking cessation on lipids and lipoproteins: outcomes from a randomized clinical trial. Am Heart J. 2011 Jan;161(1):145-51. doi: https://doi.org/10.1016/j.ahj.2010.09.023.

Naisarg Joshi, Chinmay Shah, HB Mehta, PA Gokhledone.Comparative study of lipid profile on healthy smokers and non-smokers. Int J Med Sci Public Health . 2013; 2(3): 622-626.

Cheryl S Brischetto PhD, William E. Connor MD, Sohja L. Connor MS, Joseph D. Matarazzo PhD. Plasma lipid and lipoprotein profiles of cigarette smokers from randomly selected families: Enhancement of hyperlipidemia and depression of HDL. Am J Cardiol 1983; 52(7): 675-80.

Freeman DJ, Graffin BA, Murray E, Lindsay GM, Gaffney D, Packard CJ, et al. smoking and plasma lipoprotein in man: effects on low density lipoprotein cholesterol levels and high density lipoprotein sub fraction distribution. Eur J Clin Invest. 1993;23(10) : 630-40.

Imran Khan, Mohd. Farhan, Sai Ramesh A, Padma Thiagarajan. Effects of smoking on serum lipid levels in nascent young Indian smokers. Int. J Pharma Sci And Research.2012;3(9):463-466.

Reaven G, Tsao P.S; Insulin resistance and compensatory hyperinsulinemia. The key player between cigarette smoking and cardio-vascular disease. J Am Coll Cardiol. 2003;41(6):1044-7.

Sinha AK, Misra GC, Patel DK. Effect of smoking on lipid profile in the young. J Assoc Physicians India 1995;43(3):185-8.

Dirican M , Sarandol E , Ulukaya E , Tokullugil HA. Effects of smoking on serum lipid and lipoprotein concentrations and lecithin: cholesterol acyltransferase activity. J Med Invest 1999; 46(3-4):169-72.

Nesje LA, Mjøs OD. Plasma HDLc holesterol and the subclasses HDL2 and HDL3 in smokers and nonsmokers. Artery 1985; 13(1):7-18.

Heitzer T, Yla-Herttuala S, Luoma J; Cigarette smoking potentiates endothelial dysfunction of forearm resistance vessels in patients with hypercholesterolemia. Role of oxidized LDL. Circulation. 1996;93(7):1346-1353.

Yokode M, Kita T, Arai H; Cholesteryl ester accumulation in macrophages incubated with low density lipoprotein pretreated with cigarette smoke extract. Proc Natl Acad Sci USA. 1988;85(7):2344-8.

Frei B, Forte T.M, Ames B.N, Cross C.E; Gas phase oxidants of cigarette smoke induce lipid peroxidation and changes in lipoprotein properties in human blood plasma. Protective effects of ascorbic acid. Biochem J. 277 1991;277(pt1)133-138.

Ross R; Atherosclerosis—an inflammatory disease. N Engl J Med.1999;340(24):115-26.

Clarkson T.B, Weingand K.W, Kaplan J.R; Mechanisms of atherogenesis. Circulation. 1987 Jul;76(1 Pt 2):I20-8.

Cuesta C, Sánchez-Muniz FJ, et al. Effect of age and cigarette smoking on serum concentrations of lipids and apolipoproteins in a male military population. Atherosclerosis 1989;80(1);33-9.

Arsian E, Yakar T, Yavașoğu I. The effect of smoking on mean platelet volume and lipid profile in young male subject. Anadolu Kardio Derg 2008;8(6):422-5.

Siekmeier R, März W, Kronenberger H, Seiffert UB, Gross W. Effects of cigarette smoking and plasma lipids, apolipoproteins and lipoprotein (a) in healthy subjects. Clin Chem 1994;40(7):1350-1.

Criqui MH, Wallace RB, Heiss G, et al. Cigarette smoking and plasma high density lipoprotein cholesterol.The lipid Research clinics Programme Prevalence study. Circulation, 1980;62(4):IV70-76.

Ito T, Nishiwaki M, Ishikawa T, Nakamura H. CETP and LCAT activities are unrelated to smoking and moderated alcohol consumption in healthy normolipidemic men. Jpn Circ J 1995; 59(8):541-6.

Mjøs OD. Lipid effects of smoking. Am Heart J. 1988 Jan;115(1 Pt 2):272-5.

Lopes PA, Santos MC, Vicente L, Viegas-Crespo AM. Effect of cigarette smoking on serum alpha-tocopherol and the lipid profile in a Portuguese population. Clin Chim Acta. 2004 Oct;348(1-2):49-55.

Siekmeier R, Wülfroth P, Wieland H, Gross W, März W. Low-density lipoprotein susceptibility to in vitro oxidation in healthy smokers and nonsmokers. Clin Chem. 1996 Apr;42(4):524-30.

Suleyman H, Gumustekin K, Taysi S, et al. Beneficial effects of Hippo phae rhamnoides L on nicotine induced oxidative stress in rat blood compared with vitamin E. Biol Pharm Bull 2002;25(9):1133-6.

Khurana M, Sharma D, Khandelwal PD. Lipid profile in smokers and tobacco chewers - a comparative study. J Assoc Physicians India 2000;48(9):895-7.

Ezzati M, Henley SJ, Thun MJ, Lopez AD. Role of smoking in global and regional cardiovascular mortality. Circulation. 2005 Jul 26;112(4):489-97. Epub 2005 Jul 18.

Smoking and its association with serum lipid levels
CITATION
DOI: 10.17511/ijmrr.2016.i11.28
Published: 2016-11-30
How to Cite
1.
Pratap Singh Rajput D, Gulati D, Singh P. Smoking and its association with serum lipid levels. Int J Med Res Rev [Internet]. 2016Nov.30 [cited 2024Apr.20];4(11):2064-70. Available from: https://ijmrr.medresearch.in/index.php/ijmrr/article/view/760
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Original Article