Significance of lactate dehydrogenase in prediction of pregnancy induced hypertension and its complications
Abstract
Objectives: To compare serum Lactate Dehydrogenase (LDH) level of normotensive pregnant women with those of preeclamptic and eclamptic women. To determine the relationship of levels of serum Lactate dehydrogenase with severity of pregnancy induced hypertension and its complications.
Method: The study was carried out on pregnant hypertensive patients attending outpatient department of Obstetrics and Gynaecology department, AMCH Dibrugarh, Assam from 1st July 2013 to 30th June 2014. Normotensive pregnant women were taken as controls. Each serum sample from the control group as well as study group was estimated for Lactate Dehydrogenase using standard methods and a comparison was drawn and analyzed using t-test and chi-square test.
Results: Serum Lactate Dehydrogenase level was high in the study group. The level of this enzyme was normal in the control group.
Conclusion: Serum Lactate Dehydrogenase levels in patients suffering from preeclampsia and its complications are consistently higher as compared to the normotensive pregnant patients. The usefulness of this enzyme as marker of the severity of pregnancy induced hypertension and its universal inclusion along with other cardiac enzymes in the panel of investigations of pregnant women needs further large scale comparative studies.
Downloads
References
Park K. Preventive medicine in obstetrics, pediatrics & geriatrics. In: Park K. (eds). Park’s textbook of preventive and social medicine, 21st edn. M/s Banarasidas Bhanot publishers 2011, pp514-517.
Chauhan R, Sharma RS, Parashar MK, Chauhan VS. Clinical examination of hypertension in pregnancy. In: Shah MR, editor. Hypertensive disorders in pregnancy: 1st ed. New Delhi: Jaypee Brothers Medical Publishers (P) Ltd; 2007. p. 111-25.
Trends in maternal mortality: 1990 to 2010. WHO, UNICEF, UNFPA and The World Bank estimates. Available at: http://whqlibdoc.who.int/publications/2012/9789241503631_eng.pdf. Accessed on July 12, 2012
Williams obstetrics, 23rd edition. Chapter 34. Pregnancy hypertension.
Bais R, Philcox M. Approved recommendation on IFCC methods for the measurement of catalytic concentration of enzymes. Part 8. IFCC Method for Lactate Dehydrogenase (l-Lactate: NAD+Oxidoreductase, EC 1.1.1.27). International Federation of Clinical Chemistry (IFCC). Eur J Clin Chem Clin Biochem. 1994 Aug;32(8):639-55.
Redman CWG, Sargent IL, Roberts JM: Immunology of abnormal pregnancy and preeclampsia. In Lindheimer MD, Roberts JM, Cunningham FG (eds): Chesley's Hypertensive Disorders of Pregnancy, 3rd ed. New York, Elsevier, In press, 2009, p 129.
Redman CW, Sacks GP, Sargent IL. Preeclampsia: an excessive maternal inflammatory response to pregnancy. Am J Obstet Gynecol. 1999 Feb;180(2 Pt 1):499-506.
Qublan S. Hussain,Vera Ammarin. Osama Bataineh, Ziad Al-Shraideh, Yosef Tahat, Islam Awamleh, Basel Khreisat, Bassam Nussair, Zouhairodeh Amarin: Lactate dehydogenase as a biochemical marker of adverse pregnancy in severe preeeclampsia. Med.Sci. Monit 200511(8): CR 393-0397.
Rubina Aziz, Tabassum Mahboob: Relation between preeclampsia and cardiac enzymes, Arya Atherosclerosis Journal 2008, 4(1): 29-32.
Jaiswar S P, Gupta Amrit, Sachen Rekha, Natu SN, Shaili Mohan, Lactate Dehydrogenase: A Biochemical Marker for Preeclampsia –Eclampsia. The Journal of Obstetrics and Gynecology of India (November-December 2011)61(6):645-648. DOI: https://doi.org/10.1007/s13224-011-0093-9.
Amit D. Sonagra, Dattatreya. K. Jayaprakash Murthy D. SERUM LDH, ALP AND URIC ACID IN HYPERTENSIVE DISORDERS OF PREGNANCY IJPBS (VOL-2)Issue3/JULY-SEPT/2012/201-209.
OAI - Open Archives Initiative
