Effect of Antiepileptic drugs on lipid profile in children with Epilepsy

  • Dr Jayashree Nadkarni Associate Professor, Gandhi Medical College and Associated Kamla Nehru Hospital, Bhopal (M.P), India 462016
  • Dr Deepak Kumar Uikey Post Graduate Resident, Gandhi Medical College and Associated Kamla Nehru Hospital, Bhopal (M.P), India 462016
  • Dr Utkarsh Sharma Intern, Gandhi Medical College and Associated Kamla Nehru Hospital, Bhopal (M.P), India 462016
  • Dr Rashmi Dwivedi Professor and Head, Department of Paediatrics, Gandhi Medical College and Associated Kamla Nehru Hospital, Bhopal (M.P), India 462016
DOI: https://doi.org/10.17511/ijmrr.2014.i02.09
Keywords: AED, CWE, Lipid profile, Seizures, Phenytoin, Valproic acid

Abstract

Objective: The study evaluated the effect of antiepileptic drugs on lipid profile in children with epilepsy. Demographic profile and the seizure pattern of CWE were also studied.

Material and method: 95 children aged between 2-15 years with confirmed diagnosis of primary epilepsy who were on AED for at least 3 months were the cases and 50 normal healthy children of similar age group were the controls. Children with BMI >95th entile were excluded. The cases were categorized in three groups depending upon whether they were taking either phenytoin, valproic acid alone or in combination.

Result: The Levene‘s test for homogeneity of variance indicated a significant difference in variance between the cases and control group in serum TGs, LDL-C and VLDL-C. The t-test showed a significant difference in means among cases and controls in HDL-C, LDL-C levels and the risk ratio.

Conclusion: We recommend a need for careful monitoring of lipid profile in children with epilepsy receiving antiepileptic drugs

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CITATION
DOI: 10.17511/ijmrr.2014.i02.09
Published: 2014-04-30
How to Cite
1.
Nadkarni J, Kumar Uikey D, Sharma U, Dwivedi R. Effect of Antiepileptic drugs on lipid profile in children with Epilepsy. Int J Med Res Rev [Internet]. 2014Apr.30 [cited 2024Jul.3];2(2):119-23. Available from: https://ijmrr.medresearch.in/index.php/ijmrr/article/view/72
Issue
Vol 2 No 2 (2014): Mar-Apr
Section
Original Article