Influence of gender on nerve conduction parameters of median and ulnar nerves in healthy individuals
Abstract
Background & objectives: Nerve conduction studies are used to diagnose disorders of the peripheral nervous system. They are influenced by number of variables i.e. age, gender, height, temperature, fiber diameter, degree of myelination, inter nodal distance etc. This study was conducted to analyze the effect of gender on nerve conduction parameters of upper limb nerves.
Materials & Methods: The study comprised of 50 males and 50 females between the age group of 18-25 years. Distal latency, amplitude and conduction velocity of Median and Ulnar nerve were recorded using standardized technique.
Results: The mean distal latency of sensory Median and Ulnar nerve were found to be significantly greater in males (p<0.05), whereas mean sensory amplitude was found to be significantly higher in female subjects, but the conduction velocity did not show any statistically significant difference (p>0.05). Mean distal latency and amplitude of motor median and ulnar nerve was found higher in males than females whereas conduction velocity was found to be higher in females but the difference was statistically insignificant.
Conclusion: Gender has definite and significant influence on various Nerve Conduction Parameters. Without adjustment for this factor, the sensitivity and specificity of NCS will decrease when using the same reference data in patients with different gender.
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References
Thakur D. Nerve conduction in healthy individuals. Health Renaissance. 2010 September-December; 8 (3); 169-175.doi: https://doi.org/10.3126/hren.v8i3.4210.
Wadoo Ovais Karnain,Singh Surjit,Agrawal Bimal K,Kamra Monika & Gupta Sangeeta.Gender effect on upper limb nerve conduction study in healthy individuals of North India. Journal of pharmaceutical and biomedical sciences (J Pharm Biomed Sci.) .2013 August; 33(33): 1589-1593.
Shaikh S, DaimiSayad B, Khan M M, Sami L B, Solepure A. B. Normative Values for Nerve Conduction Study among healthy subjects from Aurangabad, INDIA. International Journal of Recent Trends in Science and Technology.2013; 8(1): p 56-61.https://statperson.com/Journal/ScienceAndTechnology/Article/Volume8Issue1/8_1_16.pdf.
Misra UK, Kalita J. Nerve Conduction Study. In: Misra UK, Kalita J, editors. Clinical Neurophysiology.2nd edition. New Delhi, Elsevier 2008; p.1-10, 21-9, 32, 40.
Park K. Park's text book of preventive and social medicine.22nd ed.Bhanot; 2013.p-369.
Lafratta CW, Smith OH. A Study Of The Relationship Of Motor Nerve Conduction Velocity in The Adult to Age, Sex, and Handedness. Arch Phys Med Rehabil. 1964 Aug;45:407-12.
Stetson DS, Albers JW, Silverstein BA, Wolfe RA. Effects of age, sex, and anthropometric factors on nerve conduction measures. Muscle Nerve. 1992 Oct;15(10):1095-104.doi: https://doi.org/10.1002/mus.880151007.
Shehab DK. Normative data of nerve conduction studies in the upper limb in Kuwait: Are they different from the western data? Medical principles and practice.1998; 7: 203-8.
Kimura J. Electro diagnosis in diseases of nerve and muscle: Principles and practice.2nd ed. Philadelphia.F.A. Davis Company; 1989. (Online)
Robinson LR, Rubner DE, Wahl PW, Fujimoto WY, Stolov WC. Influences of height and gender on normal nerve conduction studies. Arch Phys Med Rehabil. 1993 Nov;74(11):1134-8.
Huang CR, Chang WN, Chang HW, Tsai NW, Lu CH. Effects of age, gender, height, and weight on late responses and nerve conduction study parameters. Acta Neurol Taiwan. 2009 Dec;18(4):242-9.
Hennessey WJ, Falco FJ, Goldberg G, Braddom RL. Gender and arm length: influence on nerve conduction parameters in the upper limb. Arch Phys Med Rehabil. 1994 Mar;75(3):265-9.doi: https://doi.org/10.1016/0003-9993(94)90026-4.
Fujimaki Y, Kuwabara S, Sato Y, Isose S, Shibuya K, Sekiguchi Y, Nasu S, Noto Y, Taniguchi J, Misawa S. The effects of age, gender, and body mass index on amplitude of sensory nerve action potentials: multivariate analyses. Clin Neurophysiol. 2009 Sep;120(9):1683-6. doi: https://doi.org/10.1016/j.clinph.2009.06.025. Epub 2009 Jul 28.
Garg R, Bansal N, Kaur H, Arora KS. Nerve conduction studies in the upper limb in the malwa region-normative data. J Clin Diagn Res. 2013 Feb;7(2):201-4. doi: https://doi.org/10.7860/JCDR/2013/4804.2727. Epub 2013 Feb 1.
Bolton CF, Carter KM. Human sensory nerve compound action potential amplitude: Variation With sex and finger circumference. J Neurol Neurosurg Psychiatry.1980 Oct; 43(10): 925-28.doi: https://doi.org/10.1136/jnnp.43.10.925.
Hennessey WJ, Falco FJ, Braddom RL. Median and ulnar nerve conduction studies: normative data for young adults. Arch Phys Med Rehabil. 1994 Mar;75(3):259-64.doi: https://doi.org/10.1016/0003-9993(94)90025-6.