A rare complication seen in a child diagnosed with acute lymphoblastic leukemia: Isolated penile gangrene

  • Dr Richa Chauhan Consultant Radiation Oncologist, Mahavir Cancer Sansthan, Patna, Bihar, India
  • Dr Gyanendra Singh Resident Surgeon, Sanjeevani Hospital, Patna, Bihar, India
  • Dr U.P Singh Consultant Surgeon Director, Sanjeevani Hospital, Patna, Bihar, India
Keywords: Leukemia, Thromboembolic events, penile gangrene

Abstract

Leukemia is the most common cancer seen in children with acute lymphoblastic leukemia, accounting for 80% of all childhood leukemias and 24% of all cancers in children. The intensive chemotherapy regimen used in the treatment is often associated with a number of complications. Thromboembolic events in the form of coagulopathy and thrombosis have been reported in patients of acute leukemia undergoing chemotherapy. In the present study, we report the case of a 10-year-old boy with acute lymphoblastic leukemia (ALL) who developed dry gangrene of the penis while on chemotherapy. Dry gangrene of the penis is a rare complication, in view of the presence of extensive collateral circulation in the region. This presentation may be correlated to a rare thrombotic complication, associated with hypercoagulable status seen in leukemic patients undergoing chemotherapy.

Downloads

Download data is not yet available.

References

Redaelli A, Laskin BL, Stephens JM, Botteman MF, Pashos CL. A systematic literature review of the clinical and epidemiological burden of acute lymphoblastic leukaemia (ALL). Eur J Cancer Care (Engl). 2005 Mar;14(1):53-62. DOI: https://doi.org/10.1111/j.1365-2354.2005.00513.x.

Athale, U.H. & Chan, A.K. (2003a) Thrombosis in children with acute lymphoblastic leukemia: part I. Epidemiology of thrombosis in children with acute lymphoblastic leukemia. Thromb Res. 2003;111(3):125-31. Review. PMID:14678808.

Athale U.H. & Chan AKC. Thrombosis in children with acute lymphoblastic leukemia: pathogenesis of thrombosis in children with acute lymphoblastic leukemia: effect of the disease and therapy. Thrombosis Res. 2003; 111: 199-212.

Payne JH, Vora AJ. Thrombosis and acute lymphoblastic leukemia. Br J Haematol. 2007 Aug;138(4):430-45. Epub 2007 Jun 29. Review.PMID:17608766.doi: https://doi.org/10.1111/j.1365-2141.2007.06677.x.

D'Arena G, Pietrantuono G, Buccino E, Pacifico G, Musto P. Fournier's Gangrene Complicating Hematologic Malignancies: a Case Report and Review of Literature. Mediterr J Hematol Infect Dis. 2013 Nov 1;5(1):e2013067. doi: https://dx.doi.org/10.4084%2FMJHID.2013.067. eCollection 2013.

Harris C.F & Mydlo JH. Ischemia and gangrene of the penis. J Urol. 2003 May;169(5):1795. DOI: https://doi.org/10.1097/01.ju.0000057796.64080.3a.

Karpman E, Das S, Kurzrock EA. Penile calciphylaxis: analysis of risk factors and mortality. J Urol. 2003 Jun;169(6):2206-9. DOI: https://doi.org/10.1097/01.ju.0000064334.85656.a1

Nigwekar SU, Wolf M, Sterns RH, Hix JK. Calciphylaxis from Nonuremic Causes: A Systematic Review. Clin J Am Soc Nephrol. 2008 Jul;3(4):1139-43. doi: https://doi.org/10.2215/CJN.00530108. Epub 2008 Apr 16. Review.

Juskiewenski, S., Vaysse, P., Moscovici, J. et al. A study of the arterial blood supply to the penis. Anat. Clin (1982) 4: 101. doi: https://doi.org/10.1007/BF01800618.

Feinberg WM, Swenson MR. Cerebrovascular complications of L- Asparaginase therapy. Neurology. 1988 Jan;38(1):127-33. PMID: 3275903.doi: https://doi.org/10.1212/wnl.38.1.127.

Vicarioto M, Rosolen A, Cappellato MG, Zanesco L, Girolami A. Greater decrease of fibrinogen as compared to antithrombin III in L-asparaginase treated leukemia patients. Folia Haematol Int Mag Klin Morphol Blutforsch. 1986;113(5):663-9. PMID: 2435632.

Parsons SK, Skapek SX, Neufeld EJ, Kuhlman C, Young ML, Donnelly M et al. Asparaginase-associated lipid abnormalities in children with acute lymphoblastic leukemia. Blood. 1997 Mar 15;89(6):1886-95. PMID: 9058708.

Abbott LS, Deevska M, Fernandez CV, Dix D, Price VE, Wang H et al. The impact of prophylactic fresh-frozen plasma and cryoprecipitate on the incidence of central nervous system thrombosis and hemorrhage in children with acute lymphoblastic leukemia receiving asparaginase. Blood. 2009 Dec 10;114(25):5146-51. doi: https://doi.org/10.1182/blood-2009-07-231084.

A rare complication seen in a child diagnosed with acute lymphoblastic leukemia: Isolated penile gangrene
CITATION
DOI: 10.17511/ijmrr.2016.i09.19
Published: 2016-09-30
How to Cite
1.
Chauhan R, Singh G, Singh U. A rare complication seen in a child diagnosed with acute lymphoblastic leukemia: Isolated penile gangrene. Int J Med Res Rev [Internet]. 2016Sep.30 [cited 2024Nov.23];4(9):1628-31. Available from: https://ijmrr.medresearch.in/index.php/ijmrr/article/view/707
Section
Case Report