Clinical Study of Pancytopenia
Keywords:
Pancytopenia, Bone marrow, Megaloblastic anemia
Abstract
Introduction: Pancytopenia is a common and alarming condition encountered by clinicians. We had studied the clinical presentation, laboratory investigations and various etiologies of Pancytopenia.
Material and Methods: Study was carried out in a tertiary care centre in western India. A total of 102 patients fulfilling the criteria of pancytopenia were enrolled and studied.
Results and conclusion: Megaloblastic anemia was commonest cause of pancytopenia. Easy fatigability and pallor were commonest symptoms and signs respectively. Maximum bleeding manifestations were seen in aplastic anemia and Myelodysplastic syndrome.
Downloads
Download data is not yet available.
References
1. Williams DM. Pancytopenia, aplastic anemia and pure red cell aplasia. Wintrobe’s Clinical Hematology. 1999;9:911-43.
2. Tilak V, Jain R. Pancytopenia--a clinico-hematologic analysis of 77 cases. Indian J Pathol Microbiol. 1999 Oct;42(4):399-404. [PubMed]
3. Khodke K, Marwah S, Buxi G, Yadav RB, Chaturvedi NK. Bone marrow examination in cases of pancytopenia. Journal, Indian Academy of Clinical Medicine. 2001Jan-June. 2001;2: 1-2. [PubMed]
4. Incidence of aplastic anemia: the relevance of diagnostic criteria. By the International Agranulocytosis and Aplastic Anemia Study. Blood. 1987 Dec;70(6):1718-21. [PubMed]
5. Keisu M, Öst Å. Diagnoses in patients with severe pancytopenia suspected of having aplastic anemia. European journal of haematology. 1990 Jul 1;45(1):11-4.
6. Bijjaragi S, Kulkarni VG, Belagatti SL, Kadam SS. Clinico-Hematological Profile of Pancytopenia in North Karnataka-One Year Study. Indian Journal of Public Health Research & Development. 2013 Apr 1;4(2):234. [PubMed]
7. Gayathri BN, Rao KS. Pancytopenia: a clinico hematological study. J Lab Physicians. 2011 Jan;3(1):15-20. doi: 10.4103/0974-2727.78555. [PubMed]
8. Doshi D, Shah AN, Somani S, Jain A, Jivarajani H, Kothari P. Study of clinical and aetiological profile of 100 patients of pancytopenia at a tertiary care centre in India. Hematology. 2012 Mar;17(2):100-5. doi: 10.1179/102453312X13221316477976. [PubMed]
9. Thakkar BB, Bhavsar UN, Trivedi NJ, Agnihotri AS. A study of pancytopenia in adult patients more than 12 years of age in North West region of saurashtra. Nat J Med Res. 2013;3(1):48-52.
10. Khanduri U, Sharma A. Megaloblastic anaemia: prevalence and causative factors. Natl Med J India. 2007 Jul-Aug;20(4):172-5. [PubMed]
11. Hesdorffer CS, Longo DL. Drug-Induced Megaloblastic Anemia. N Engl J Med. 2015 Oct 22;373(17):1649-58. doi: 10.1056/NEJMra1508861. [PubMed]
12. A Victor Hoffband. Harrison’s Principle of Internal Medicine 19th edition. New York: Mc Graw Hill Education; 2015 Chapter128, Megaloblastic anemias; p640-644.
13. Santra G, Das BK. A cross-sectional study of the clinical profile and aetiological spectrum of pancytopenia in a tertiary care centre. Singapore Med J. 2010 Oct;51(10):806-12.
14. Jain A, Naniwadekar M. An etiological reappraisal of pancytopenia-largest series reported to date from a single tertiary care teaching hospital. BMC Blood Disorders. 2013 Nov 6;13(1):1.
15. Killick SB, Bown N, Cavenagh J, Dokal I, Foukaneli T, Hill A, Hillmen P, Ireland R, Kulasekararaj A, Mufti G, Snowden JA, Samarasinghe S, Wood A0, Marsh JC; British Society for Standards in Haematology. Guidelines for the diagnosis and management of adult aplastic anaemia. Br J Haematol. 2016 Jan;172(2):187-207. doi: 10.1111/bjh.13853. Epub 2015 Nov 16.
16. Hamid GA, Shukry SA. Patterns of pancytopenia in Yemen. Turk J Haematol. 2008 Jun 5;25(2):71-4. [PubMed]
17. Dasgupta S, Mandal PK, Chakrabarti S. Etiology of Pancytopenia: An Observation from a Referral Medical Institution of Eastern Region of India. J Lab Physicians. 2015 Jul-Dec;7(2):90-5. doi: 10.4103/0974-2727.163136.
18. Premkumar M, Gupta N, Singh T, Velpandian T. Cobalamin and folic Acid status in relation to the etiopathogenesis of pancytopenia in adults at a tertiary care centre in north India. Anemia. 2012;2012:707402. doi: 10.1155/2012/707402. Epub 2012 Apr 1. [PubMed]
19. Simmons CP, Farrar JJ, Nguyen vV, Wills B. Dengue. N Engl J Med. 2012 Apr 12;366(15):1423-32. doi: 10.1056/NEJMra1110265. [PubMed]
20. Pereira RM, Velloso ER, Menezes Y, Gualandro S, Vassalo J, Yoshinari NH. Bone marrow findings in systemic lupus erythematosus patients with peripheral cytopenias. Clinical rheumatology. 1998 May 1;17(3):219-22.
21. Kar M, Ghosh A. Pancytopenia. J Indian Acad Clin Med. 2002 Jan;3(1):29-34.
2. Tilak V, Jain R. Pancytopenia--a clinico-hematologic analysis of 77 cases. Indian J Pathol Microbiol. 1999 Oct;42(4):399-404. [PubMed]
3. Khodke K, Marwah S, Buxi G, Yadav RB, Chaturvedi NK. Bone marrow examination in cases of pancytopenia. Journal, Indian Academy of Clinical Medicine. 2001Jan-June. 2001;2: 1-2. [PubMed]
4. Incidence of aplastic anemia: the relevance of diagnostic criteria. By the International Agranulocytosis and Aplastic Anemia Study. Blood. 1987 Dec;70(6):1718-21. [PubMed]
5. Keisu M, Öst Å. Diagnoses in patients with severe pancytopenia suspected of having aplastic anemia. European journal of haematology. 1990 Jul 1;45(1):11-4.
6. Bijjaragi S, Kulkarni VG, Belagatti SL, Kadam SS. Clinico-Hematological Profile of Pancytopenia in North Karnataka-One Year Study. Indian Journal of Public Health Research & Development. 2013 Apr 1;4(2):234. [PubMed]
7. Gayathri BN, Rao KS. Pancytopenia: a clinico hematological study. J Lab Physicians. 2011 Jan;3(1):15-20. doi: 10.4103/0974-2727.78555. [PubMed]
8. Doshi D, Shah AN, Somani S, Jain A, Jivarajani H, Kothari P. Study of clinical and aetiological profile of 100 patients of pancytopenia at a tertiary care centre in India. Hematology. 2012 Mar;17(2):100-5. doi: 10.1179/102453312X13221316477976. [PubMed]
9. Thakkar BB, Bhavsar UN, Trivedi NJ, Agnihotri AS. A study of pancytopenia in adult patients more than 12 years of age in North West region of saurashtra. Nat J Med Res. 2013;3(1):48-52.
10. Khanduri U, Sharma A. Megaloblastic anaemia: prevalence and causative factors. Natl Med J India. 2007 Jul-Aug;20(4):172-5. [PubMed]
11. Hesdorffer CS, Longo DL. Drug-Induced Megaloblastic Anemia. N Engl J Med. 2015 Oct 22;373(17):1649-58. doi: 10.1056/NEJMra1508861. [PubMed]
12. A Victor Hoffband. Harrison’s Principle of Internal Medicine 19th edition. New York: Mc Graw Hill Education; 2015 Chapter128, Megaloblastic anemias; p640-644.
13. Santra G, Das BK. A cross-sectional study of the clinical profile and aetiological spectrum of pancytopenia in a tertiary care centre. Singapore Med J. 2010 Oct;51(10):806-12.
14. Jain A, Naniwadekar M. An etiological reappraisal of pancytopenia-largest series reported to date from a single tertiary care teaching hospital. BMC Blood Disorders. 2013 Nov 6;13(1):1.
15. Killick SB, Bown N, Cavenagh J, Dokal I, Foukaneli T, Hill A, Hillmen P, Ireland R, Kulasekararaj A, Mufti G, Snowden JA, Samarasinghe S, Wood A0, Marsh JC; British Society for Standards in Haematology. Guidelines for the diagnosis and management of adult aplastic anaemia. Br J Haematol. 2016 Jan;172(2):187-207. doi: 10.1111/bjh.13853. Epub 2015 Nov 16.
16. Hamid GA, Shukry SA. Patterns of pancytopenia in Yemen. Turk J Haematol. 2008 Jun 5;25(2):71-4. [PubMed]
17. Dasgupta S, Mandal PK, Chakrabarti S. Etiology of Pancytopenia: An Observation from a Referral Medical Institution of Eastern Region of India. J Lab Physicians. 2015 Jul-Dec;7(2):90-5. doi: 10.4103/0974-2727.163136.
18. Premkumar M, Gupta N, Singh T, Velpandian T. Cobalamin and folic Acid status in relation to the etiopathogenesis of pancytopenia in adults at a tertiary care centre in north India. Anemia. 2012;2012:707402. doi: 10.1155/2012/707402. Epub 2012 Apr 1. [PubMed]
19. Simmons CP, Farrar JJ, Nguyen vV, Wills B. Dengue. N Engl J Med. 2012 Apr 12;366(15):1423-32. doi: 10.1056/NEJMra1110265. [PubMed]
20. Pereira RM, Velloso ER, Menezes Y, Gualandro S, Vassalo J, Yoshinari NH. Bone marrow findings in systemic lupus erythematosus patients with peripheral cytopenias. Clinical rheumatology. 1998 May 1;17(3):219-22.
21. Kar M, Ghosh A. Pancytopenia. J Indian Acad Clin Med. 2002 Jan;3(1):29-34.
CITATION
DOI: 10.17511/ijmrr.2016.i09.06
Published: 2016-09-30
How to Cite
1.
Vaidya M, Anand Gupta V, Khandagale S. Clinical Study of Pancytopenia. Int J Med Res Rev [Internet]. 2016Sep.30 [cited 2024Nov.5];4(9):1551-8. Available from: https://ijmrr.medresearch.in/index.php/ijmrr/article/view/684
Section
Original Article
OAI - Open Archives Initiative
