Clinical Study of Pancytopenia
Keywords:
Pancytopenia, Bone marrow, Megaloblastic anemia
Abstract
Introduction: Pancytopenia is a common and alarming condition encountered by clinicians. We had studied the clinical presentation, laboratory investigations and various etiologies of Pancytopenia.
Material and Methods: Study was carried out in a tertiary care centre in western India. A total of 102 patients fulfilling the criteria of pancytopenia were enrolled and studied.
Results and conclusion: Megaloblastic anemia was commonest cause of pancytopenia. Easy fatigability and pallor were commonest symptoms and signs respectively. Maximum bleeding manifestations were seen in aplastic anemia and Myelodysplastic syndrome.
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References
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2. Tilak V, Jain R. Pancytopenia--a clinico-hematologic analysis of 77 cases. Indian J Pathol Microbiol. 1999 Oct;42(4):399-404. [PubMed]
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13. Santra G, Das BK. A cross-sectional study of the clinical profile and aetiological spectrum of pancytopenia in a tertiary care centre. Singapore Med J. 2010 Oct;51(10):806-12.
14. Jain A, Naniwadekar M. An etiological reappraisal of pancytopenia-largest series reported to date from a single tertiary care teaching hospital. BMC Blood Disorders. 2013 Nov 6;13(1):1.
15. Killick SB, Bown N, Cavenagh J, Dokal I, Foukaneli T, Hill A, Hillmen P, Ireland R, Kulasekararaj A, Mufti G, Snowden JA, Samarasinghe S, Wood A0, Marsh JC; British Society for Standards in Haematology. Guidelines for the diagnosis and management of adult aplastic anaemia. Br J Haematol. 2016 Jan;172(2):187-207. doi: 10.1111/bjh.13853. Epub 2015 Nov 16.
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17. Dasgupta S, Mandal PK, Chakrabarti S. Etiology of Pancytopenia: An Observation from a Referral Medical Institution of Eastern Region of India. J Lab Physicians. 2015 Jul-Dec;7(2):90-5. doi: 10.4103/0974-2727.163136.
18. Premkumar M, Gupta N, Singh T, Velpandian T. Cobalamin and folic Acid status in relation to the etiopathogenesis of pancytopenia in adults at a tertiary care centre in north India. Anemia. 2012;2012:707402. doi: 10.1155/2012/707402. Epub 2012 Apr 1. [PubMed]
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21. Kar M, Ghosh A. Pancytopenia. J Indian Acad Clin Med. 2002 Jan;3(1):29-34.
2. Tilak V, Jain R. Pancytopenia--a clinico-hematologic analysis of 77 cases. Indian J Pathol Microbiol. 1999 Oct;42(4):399-404. [PubMed]
3. Khodke K, Marwah S, Buxi G, Yadav RB, Chaturvedi NK. Bone marrow examination in cases of pancytopenia. Journal, Indian Academy of Clinical Medicine. 2001Jan-June. 2001;2: 1-2. [PubMed]
4. Incidence of aplastic anemia: the relevance of diagnostic criteria. By the International Agranulocytosis and Aplastic Anemia Study. Blood. 1987 Dec;70(6):1718-21. [PubMed]
5. Keisu M, Öst Å. Diagnoses in patients with severe pancytopenia suspected of having aplastic anemia. European journal of haematology. 1990 Jul 1;45(1):11-4.
6. Bijjaragi S, Kulkarni VG, Belagatti SL, Kadam SS. Clinico-Hematological Profile of Pancytopenia in North Karnataka-One Year Study. Indian Journal of Public Health Research & Development. 2013 Apr 1;4(2):234. [PubMed]
7. Gayathri BN, Rao KS. Pancytopenia: a clinico hematological study. J Lab Physicians. 2011 Jan;3(1):15-20. doi: 10.4103/0974-2727.78555. [PubMed]
8. Doshi D, Shah AN, Somani S, Jain A, Jivarajani H, Kothari P. Study of clinical and aetiological profile of 100 patients of pancytopenia at a tertiary care centre in India. Hematology. 2012 Mar;17(2):100-5. doi: 10.1179/102453312X13221316477976. [PubMed]
9. Thakkar BB, Bhavsar UN, Trivedi NJ, Agnihotri AS. A study of pancytopenia in adult patients more than 12 years of age in North West region of saurashtra. Nat J Med Res. 2013;3(1):48-52.
10. Khanduri U, Sharma A. Megaloblastic anaemia: prevalence and causative factors. Natl Med J India. 2007 Jul-Aug;20(4):172-5. [PubMed]
11. Hesdorffer CS, Longo DL. Drug-Induced Megaloblastic Anemia. N Engl J Med. 2015 Oct 22;373(17):1649-58. doi: 10.1056/NEJMra1508861. [PubMed]
12. A Victor Hoffband. Harrison’s Principle of Internal Medicine 19th edition. New York: Mc Graw Hill Education; 2015 Chapter128, Megaloblastic anemias; p640-644.
13. Santra G, Das BK. A cross-sectional study of the clinical profile and aetiological spectrum of pancytopenia in a tertiary care centre. Singapore Med J. 2010 Oct;51(10):806-12.
14. Jain A, Naniwadekar M. An etiological reappraisal of pancytopenia-largest series reported to date from a single tertiary care teaching hospital. BMC Blood Disorders. 2013 Nov 6;13(1):1.
15. Killick SB, Bown N, Cavenagh J, Dokal I, Foukaneli T, Hill A, Hillmen P, Ireland R, Kulasekararaj A, Mufti G, Snowden JA, Samarasinghe S, Wood A0, Marsh JC; British Society for Standards in Haematology. Guidelines for the diagnosis and management of adult aplastic anaemia. Br J Haematol. 2016 Jan;172(2):187-207. doi: 10.1111/bjh.13853. Epub 2015 Nov 16.
16. Hamid GA, Shukry SA. Patterns of pancytopenia in Yemen. Turk J Haematol. 2008 Jun 5;25(2):71-4. [PubMed]
17. Dasgupta S, Mandal PK, Chakrabarti S. Etiology of Pancytopenia: An Observation from a Referral Medical Institution of Eastern Region of India. J Lab Physicians. 2015 Jul-Dec;7(2):90-5. doi: 10.4103/0974-2727.163136.
18. Premkumar M, Gupta N, Singh T, Velpandian T. Cobalamin and folic Acid status in relation to the etiopathogenesis of pancytopenia in adults at a tertiary care centre in north India. Anemia. 2012;2012:707402. doi: 10.1155/2012/707402. Epub 2012 Apr 1. [PubMed]
19. Simmons CP, Farrar JJ, Nguyen vV, Wills B. Dengue. N Engl J Med. 2012 Apr 12;366(15):1423-32. doi: 10.1056/NEJMra1110265. [PubMed]
20. Pereira RM, Velloso ER, Menezes Y, Gualandro S, Vassalo J, Yoshinari NH. Bone marrow findings in systemic lupus erythematosus patients with peripheral cytopenias. Clinical rheumatology. 1998 May 1;17(3):219-22.
21. Kar M, Ghosh A. Pancytopenia. J Indian Acad Clin Med. 2002 Jan;3(1):29-34.
CITATION
DOI: 10.17511/ijmrr.2016.i09.06
Published: 2016-09-30
How to Cite
1.
Vaidya M, Anand Gupta V, Khandagale S. Clinical Study of Pancytopenia. Int J Med Res Rev [Internet]. 2016Sep.30 [cited 2024Dec.23];4(9):1551-8. Available from: https://ijmrr.medresearch.in/index.php/ijmrr/article/view/684
Section
Original Article
OAI - Open Archives Initiative
