Missed a beat: Is it your Ayurvedic drug?
Abstract
24 year male presented with watery diarrhoea, 10-15 episodes/day since 2 days, vomiting, abdominal pain and giddiness since 1 day. Patient was hypotensive and had bradycardia. Rest of systemic examination was normal. ECG showed junctional bradycardia. Serum electrolytes, creatinine, Thyroid Function Tests were within normal limits. Troponin T levels were normal. On enquiry, patient gave history of ingestion of ayurvedic drug Tribhuvankirtiras and mahashankvati for 1 day prior to symptoms, for dyspepsia. Patient was started on inotropic support with fluid correction for hypotension. Clinical diagnosis of arsenic and aconite toxicity was made. The drug samples showed high levels of Arsenic and Mercury. Aconite level could not be done due to unavailability of resources. Diagnosis of drug induced aconite and arsenic toxicity was made. With discontinuation of ayurvedic drugs and supportive management, patient improved symptomatically within 3 days with restoration of normal sinus rhythm.
Downloads
References
Thatte UM, Rege NN, Phatak SD, Dahanukar SA. The flip side of Ayurveda. J Postgrad Med. 1993 Oct-Dec;39(4):179-82, 182a-182b.
Sarkar PK, Chaudhari S, Chattopadhyay A. Concept of interactions between consumable substances iAyurveda with special reference to foods and drugs. Drug Metabol Drug Interact. 2013;28(3):147-52. doi: https://doi.org/10.1515/dmdi-2013-0014.
Ernst E. Adverse effects of herbal drugs in dermatology. Br J Dermatol. 2000 Nov;143(5):923-9.doi: https://doi.org/10.1046/j.1365-2133.2000.03822.x.
Shivamurthy RP, Kallappa R, Reddy SG, Rangappa DK. Steven-Johnson syndrome due to unknown drugs [corrected]. Indian J Pharmacol. 2012 Jan;44(1):134-5. doi: https://doi.org/10.4103/0253-7613.91888.
Acharya Jadavji Trikramji., editor. 5th ed . Varanasi: Chaukhambha Sanskrit Sansthan; 2001. “1stAdhyaya” Charak Samhita; p. 23.
Rastogi S, Rastogi R, Singh R. Adverse effects of Ayurvedic drugs: An overview of causes and possibilities in reference to a case of Vatsanabha (Aconite) overdosing. International Journal of Risk and Safety in Medicine. 2007; 19(3): 117-125.
Panda AK, Debnath SK. Overdose effect of aconite containing Ayurvedic Medicine ('Mahashankha Vati'). Int J Ayurveda Res. 2010 Jul;1(3):183-6. doi: https://dx.doi.org/10.4103%2F0974-7788.72493.
Lin CC, Chan TY, Deng JF. Clinical features and management of herb-induced aconitine poisoning. Ann Emerg Med. 2004 May;43(5):574-9.doi: https://doi.org/10.1016/j.annemergmed.2003.10.046.
Chan TY. Aconite poisoning. Clin Toxicol (Phila). 2009 Apr;47(4):279-85. doi: https://doi.org/10.1080/15563650902904407.
Joseph SY, Varsha S, Kothari DC. Determination of mercury and arsenic content in a few Indian ayurvedic medicines by means of energy dispersive Xray fluorescence. Int J Pixe . 2009; 19(3): 77.