A Study of cardiac functions in type-2 diabetic patients

  • Dr Priyambada Panda PhD Student com Tutor, Department of Physiology, IMS & SUM Hospital, Bhubaneswar, Odishsa, India
  • Dr Dipti Mohapatra Associate Professor, Department of Physiology, IMS & SUM Hospital, Bhubaneswar, Odishsa, India
  • Dr Sitansu K. Panda Professor, Department of Anatomy, IMS & SUM Hospital, Bhubaneswar, Odishsa, India
  • Dr Tapaswini Mishra Assistant Professor, Department of Physiology, IMS & SUM Hospital, Bhubaneswar, Odishsa, India
  • Dr Nibedita Priyadarsini Associate Professor, Department of Physiology, IMS & SUM Hospital, Bhubaneswar, Odishsa, India
  • Dr Manasi Behera Associate Professor, Department of Physiology, IMS & SUM Hospital, Bhubaneswar, Odishsa, India
Keywords: Diabetic cardiomyopathy, Diabetes mellitus, Doppler echocardiography, Left ventricle

Abstract

Introduction: The cardiomyopathy in diabetes mellitus (DM) is the disorders in cardiac muscle due to prolonged exposure of vascular tissues to hyperglycemia in DM; and is termed as diabetic cardiomyopathy (DC). The early pre-clinical features of DC are the left ventricular diastolic dysfunction (LVDD), preceding the systolic dysfunction and being able to evolve to symptomatic heart failure.

Methods: A cross-sectional study was done including 50 DM-2 patients without any feature of cardiovascular involvement and blood pressure less than 130/80 mmHg. Doppler echocardiography was done to evaluate LVDD.

Results: In this study results showed diastolic dysfunction was more common among female than male. The prevalence of diastolic dysfunction is more in cases of longer duration of DM.

Conclusion: Our study supports other studies that myocardial damage in DM-2 affects diastolic dysfunction before systolic dysfunction. As Doppler echocardiography is a simple non-invasive procedure to assess cardiac function, so in diabetes it should be done routinely in DM for early diagnosis and prevention of further complications.

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References

Hameedullah, Faheem M, Khan SB, Hafizullah M. Prevalence of asymptomatic left ventricular diastolic dysfunction in normotensive type 2 diabetic patients. J Postgrad Med Inst [Internet]. 2010 ;24(3):188-92. https://www.jpmi.org.pk/index.php/jpmi/article/view/1072.

Bhatt JK, Thomas S, Nanjan MJ. Effect of Oral Supplementation of Vitamin C on Glycemic Control and Lipid Profile in Patients With Type 2 Diabetes Mellitus. Int J Pharm Sci. 2012 Jan;4(2):524-27.doi: https://innovareacademics.in/journal/ijpps/Vol4Issue2/3541.pdf.

Verma S, Sagar N, Vats P, Shukla K N, Abbas M, Benerje M. Antioxidant enzyme levels as markers for type 2 diabetes mellitus. Int J Bioassays. 2013;02(04):685–90.https://www.ijbio.com/articles/antioxidant-enzyme-levels-as-markers-for-type-2-diabetes-mellitus.pdf.

Kuchake VG, Upasani CD. Evaluation of Protective Effect of Antioxidant Vitamins in Patients with Diabetic Nephropathy. Asian Pharm Clin Res.2011;4(4):52-54.https://innovareacademics.in/journal/ajpcr/Vol4Issue4/467.pdf.

Khalil SI, Kamal A, Hashim F et al. Study of Left Ventricular Diastolic Function in Patients with Diabetes Mellitus.Sudan J Med Sci. 2007;2(June):85–90.doi: http://dx.doi.org/10.4314/sjms.v2i2.38469.

Patil MB, Burji NP. Ehocardiographic evaluation of diastolic dysfunction in asymptomatic type 2 diabetes mellitus. J Assoc Phsicians India.2012 May;60(5):23-6.http://www.japi.org/may_2012/05_oa_echocardiographic_evaluation_of.pdf.

Fauci AS, Braunwald E, Kasper DL, Hauser S, Longo DL, Jameson JL, et al.,editors. Harrison’s principles of internal medicine.19th ed. United state of America: cenveo publisher services;2015.

David SHBell. Heart failure: The frequent, forgotten, and often fatal complication of diabetes. Diabetes Care. 2003 Aug;26(8):2433–41. Doi: http://dx.doi.org/10.2337/diacare.26.8.2433

Dikshit NM, Wadia PZ, Shukla DK. Diastolic dysfunction in Diabetes Mellitus. Natl J Med Res. 2013; 3(3): 249-252.

Patil VC, Patil HV, Shah KB, Vasani JD, Shetty P. Diastolic dysfunction in asymptomatic type 2 diabetes mellitus with normal systolic function. J Cardiovasc Dis Res. 2011;2(4):213–222. Doi: http://dx.doi.org/10.4103/0975-3583.89805.

Albanna II, Eichelberger SM, Khoury PR, Witt SA, Standiford DA, Dolan LM, Daniels SR KT. Diastolic dysfunction in young patients with insulin-dependent diabetes mellitus as determined by automated border detection. J Am Soc Echocardiogr. 1998;11(4):349–55. Doi: http://dx.doi.org/10.1016/S0894-7317(98)70102-6

Khan KA, Jalal S, Baba RM, Jan V, Rather H, Alai M, Lone NA, Malik AR. Prevalence of diastolic dysfunction in normotensive asymptomatic patients with well controlled type2 diabetes mellitus. JOURNAL of CHINESE CLINICAL MEDICINE. 2006 Sep;1(4):193-200.

Poirier P, Bogaty P, Garneau C, Marois L, Dusmenil J. Diastolic Dysfunction in Normotensive men with well-controlled type 2 diabetes. Diabetes Care. 2001;24(1):5–10. Doi: http://dx.doi.org/10.2337/diacare.24.1.5

Schannwell CM, Schoebel FC, Heggen S, et al. Early decrease in diastolic function in young type I diabetic patients as an initial manifestation of diabetic cardiomyopathy. Z Kardiol. 1999;88(5):338–46. Doi: http://dx.doi.org/ 10.1007/s003920050295

Raev DC. Which left ventricular function is impaired earlier in the evolution of Diabetic cardiomyopathy? An Echocardiographic study of young type 1 diabetic patients. Diabetes Care. 1994 Jul;17(7):633-39. PMID: http://www.ncbi.nlm.nih.gov/pubmed/7924771

Zarich SW, Arbuckle BE, Cohen LR, et al. Diastolic abnormalities in young asymptomatic diabetic patients assessed by Pulsed Doppler Echo. J Am Coll Cardiology. 1988 Jul;12(1):114-20. PMID: http://www.ncbi.nlm.nih.gov/pubmed/3379197

Riggs TW, Transue D. Doppler Echocardiographic evaluation of left ventricular diastolic dysfunction in adolescents with Diabetes Mellitus. Am J Cardiol. 1990 Apr;65(13):899-902. PMID: http://www.ncbi.nlm.nih.gov/pubmed/2321540

Cohn JN, Johnson G. Heart failure with normal Ejection Fraction: the V-HeFT study. Circulation. 1990 Feb;81(2 suppl): III 48-53. PMID: http://www.ncbi.nlm.nih.gov/pubmed/2321540

Forman DE, Manning WJ, Hauser R, et al. Enhanced left ventricular diastolic filling associated with long-term endurance training. J Gerontol. 1992 Mar;47(2):M56-8. PMID: http://www.ncbi.nlm.nih.gov/pubmed/1538067

Zahiti BF, Gorani DR, Gashi FB, et al. Left Ventricular Diastolic Dysfunction in Asymptomatic Type 2 Diabetic Patients: Detection and Evaluation by Tissue Doppler Imaging. Acta Inform Med. 2013 Jun; 21(2): 120-23. Doi: https://doi.org/10.5455/aim.2013.21.120-123.

Ren J, Davidoff AJ. Diabetes rapidly induces contractile dysfunctions in isolated ventricular myocites. Am j Physiol. 1997 Jan;272(1): H 148-58. URL: http://jpheart.physiology.org/content/272/1/H148.abstract

Boudina S, Abel ED. Diabetic cardiomyopathy revisited. Circulation. 2007 Jun;115(25): 3213-23. Doi: https://doi.org/10.1161/CIRCULATIONAHA.106.679597.

Asghar O, AI Sunni A, Khavandi K, et al. Diabetic cardiomyopathy. Clin Sci (lond).2009; 116(10): 741-60. Doi: https://doi.org/10.1042/CS20080500.

Frustaci A, Kajstura J, Chimenti C, et al. Myocardial cell death in human diabetes. Circ Res.2000; 87(12): 1123-32. Doi: https://doi.org/10.1161/01.RES.87.12.1123.

Poulsen MK, Henriksen JE, Dahl J, et al. Left Ventricular Diastolic Function in Type @ Diabetes Mellitus: Prevalence and Association with Myocardial and Vascular Disease. 2010 Jan;3(1):24-31. Doi: https://doi.org/10.1161/CIRCIMAGING.109.855510. Epub 2009 Oct 21.

Annonu AK, Fattah AA, Mokhtar MS, et al. Left ventricular systolic and diastolic functional abnormalities in asymptomatic patients with non-insulin-dependent diabetes mellitus. J.Am.Soc.Echocardiogr.2001 Sep; 14(9):885-91.Doi: https://doi.org/10.1067/mje.2001.112892.

Illan F, Valdes-Chavarri, Tebar J, et al. Anatomical and functional cardiac abnormalities in type 1 DM. Clin Invest. 1992 May; 70(5):403-10.Doi: https://doi.org/10.1007/BF00235521.

Diamant M, Lamb HJ, Groeneveld Y, et al. Diastolic dysfunction is associated with altered myocardial metabolism in asymptomatic, normotensive patients with well-controlled type 2 diabetes mellitus. J Am Coll Cardiol. 2003;42:328-35. PMID: http://www.ncbi.nlm.nih.gov/pubmed/12875772.

A Study of cardiac functions in type-2 diabetic patients
CITATION
DOI: 10.17511/ijmrr.2016.i07.25
Published: 2016-07-31
How to Cite
1.
Panda P, Mohapatra D, K. Panda S, Mishra T, Nibedita P, Behera M. A Study of cardiac functions in type-2 diabetic patients. Int J Med Res Rev [Internet]. 2016Jul.31 [cited 2024Dec.23];4(7):1221-7. Available from: https://ijmrr.medresearch.in/index.php/ijmrr/article/view/627
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