Transient acute paralysis (? Toxicity of ayurvedic medications) - a case report
Abstract
Ayurvedic medicines have a long history of usage in Indian history. Side effects have been listed but enough experience of side effects and toxicity in humans is unknown. Here is a case presented with possible toxicity of Brahmi, Ashwagandha and Shankhpushpi or synergism of side effects resulting in transient paralysis which relieved completely and spontaneously within few days.
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References
USDA, Bacopa Monnieri information from NPGS/GRIN Proc. Acad. Nat. Sci. Philadelphia 98:94. 1946 http://www.ars.grin.gov/cgi-bin/npgs/html/taxon.pl?102292
The Wikipedia Encyclopedia http://en.wikipedia.org/wiki/Bacopa_monnieri
Dr. David Frawley & Dr. Vasant Lad, Yoga of Herbs. Lotus press 2001, 239-241
Pole S. Ayurvedic medicine: the principles of traditional practice. Elsevier Health Sciences; 2006.
D. sudharani,K.L.Krishna,K.Deval, A.K.Safia and Priya, “Pharmacological profiles of Bacopa monnieri: a review” Int J Pharm. 2011;1(1):15-23.
Deocaris CC, Widodo N, Wadhwa R, Kaul SC. Merger of ayurveda and tissue culture-based functional genomics: inspirations from systems biology. Journal of translational medicine. 2008 Mar 18;6(1):1.doi: https://doi.org/10.1186/1479-5876-6-14.
Modak M, Dixit P, Londhe J, Ghaskadbi S, Devasagayam TP. Indian herbs and herbal drugs used for the treatment of diabetes. J Clin Biochem Nutr. 2007 May;40(3):163-73. doi: https://dx.doi.org/10.3164%2Fjcbn.40.163.
[No authors listed]Monograph. Withania somnifera. Altern Med Rev. 2004 Jun;9(2):211-4.
Mishra S, Srivastava S, Dwivedi S, Tripathi RD. Investigation of biochemical responses of Bacopa monnieri L. upon exposure to arsenate. Environ Toxicol. 2013 Aug;28(8):419-30. doi: https://doi.org/10.1002/tox.20733. Epub 2011 Jun 7.
Ramanathan M, Balaji B, Justin A. Behavioural and neurochemical evaluation of Perment an herbal formulation in chronic unpredictable mild stress induced depressive model. Indian J Exp Biol. 2011 Apr;49(4):269-75.
Velmurugan K, Alam J, McCord JM, Pugazhenthi S. Synergistic induction of heme oxygenase-1 by the components of the antioxidant supplement Protandim. Free Radic Biol Med. 2009 Feb 1;46(3):430-40. doi: https://doi.org/10.1016/j.freeradbiomed.2008.10.050. Epub 2008 Nov 17.
Kapoor R, Srivastava S, Kakkar P. Bacopa monnieri modulates antioxidant responses in brain and kidney of diabetic rats. Environ Toxicol Pharmacol. 2009 Jan;27(1):62-9. doi: https://doi.org/10.1016/j.etap.2008.08.007. Epub 2008 Sep 2.
Singh A, Singh SK. Evaluation of antifertility potential of Brahmi in male mouse. Contraception. 2009 Jan;79(1):71-9. doi: https://doi.org/10.1016/j.contraception.2008.07.023. Epub 2008 Sep 18. See 1 citation found using an alternative search:
Morgan A, Stevens J Does.Bacopa monnieri improve memory performance in older persons? Results of a randomized, placebo-controlled,double-blind trial. J Altern Complement Med. 2010 Jul;16(7):753-9. doi: https://doi.org/10.1089/acm.2009.0342.
Vollala VR, Upadhya S, Nayak S.Enhanced dendritic arborization of amygdala neurons during growth spurt periods in rats orally intubated with Bacopa monniera extract. Anat Sci Int. 2011 Dec;86(4):179-88. doi: https://doi.org/10.1007/s12565-011-0104-z. Epub 2011 Mar 17.
Carlo Calabrese, N.D., M.P.H. William L. Gregory, Ph.D., Michael Leo, Ph.D., Dale Kraemer, Ph.D., Kerry Bone, F.N.I.M.H., F.N.H.A.A., and Barry Oken, M.D.Effects of a standardized Bacopa monnieri extract on cognitive performance, anxiety, and depression in the elderly: a randomized, double-blind, placebo-controlled trial J Altern Complement Med. 2008 Jul; 14(6): 707–713. doi: https://doi.org/10.1089/acm.2008.0018.
Stough C, Downey LA, Lloyd J, Silber B, Redman S, Hutchison C, Wesnes K, Nathan PJ. Examining the nootropic effects of a special extract of Bacopa monniera on human cognitive functioning: 90 day double-blind placebo-controlled randomized trial. Phytother Res. 2008 Dec;22(12):1629-34. doi: https://doi.org/10.1002/ptr.2537.
Neeraj K. Sethiya, Ashish Trivedi, Mayur B. Patel, and S. H. Mishra. An update on Shankhpushpi, a cognition-boosting Ayurvedic medicine. J Adv Pharm Technol Res. 2010 Oct-Dec; 1(4): 388–395.doi: http://www.japtr.org/text.asp?2010/1/4/388/76437.
Pawar SA, Dhuley JN, Naik SA. Neuropharmacology of an extract derived from Convolvulus microphyllus. Pharm Biol. 2001;39:253–258.doi: https://doi.org/10.1076/phbi.39.4.253.5920.
M. Owais, K.S. Sharad, A. Shehbaz, M. Saleemuddin Antibacterial efficacy of Withania somnifera (ashwagandha) an indigenous medicinal plant against experimental murine salmonellosis . Phytomedicine. 2005 Mar;12(3):229-35.doi: https://doi.org/10.1016/j.phymed.2003.07.012.
Jilani K, Lupescu A, Zbidah M, Shaik N, Lang F. Withaferin A-stimulated Ca2+ entry, ceramide formation and suicidal death of erythrocytes. Toxicol In Vitro. 2013 Feb;27(1):52-8. doi: https://doi.org/10.1016/j.tiv.2012.09.004. Epub 2012 Sep 16.
Aphale AA, Chhibba AD, Kumbhakarna NR, Mateenuddin M, Dahat SH. Subacute toxicity study of the combination of ginseng (Panax ginseng) and ashwagandha (Withania somnifera) in rats: a safety assessment. Indian J Physiol Pharmacol. 1998 Apr;42(2):299-302.https://www.ijpp.com/IJPP%20archives/1998_42_2/299-302.pdf.
van der Hooft CS, Hoekstra A, Winter A, de Smet PA, Stricker BH. [Thyrotoxicosis following the use of ashwagandha]. Ned Tijdschr Geneeskd. 2005 Nov 19;149(47):2637-8.
Panda S, Kar A. Changes in thyroid hormone concentrations after administration of ashwagandha root extract to adult male mice. J Pharm Pharmacol. 1998 Sep;50(9):1065-8.doi: https://doi.org/10.1111/j.2042-7158.1998.tb06923.x.
Panda S, Kar A. Withania somnifera and Bauhinia purpurea in the regulation of circulating thyroid hormone concentrations in female mice. J Ethnopharmacol. 1999 Nov 1;67(2):233-9.doi: https://doi.org/10.1016/s0378-8741(99)00018-5.
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