Atherosclerosis regression of intima-media wall thickness of internal carotid artery with long term use of flavonoids & antioxidants
Abstract
Introduction: Free radicals of oxygen causes an abnormal intravascular lipid peroxidase activity and start process of atherosclerosis within blood vessels. Atherosclerosis reversal has been studied in humans and animals. Flavonoids are of plant origin and these are special antioxidant molecules. Arthrosclerosis regression was studied with long term use of Flavonoids and other antioxidants.
Material and Methods: This prospective controlled trial study was done on 80 ischemic heart disease patients with effort angina having ST segment depression or elevation of more than 1mm in their normal electrocardiogram. 46 subjects of Group A taken as STUDY group were given Flavonoids Antioxidant combination for a period of 9 months as an adjuvant therapy along with routine medical management. Results of baseline study were compared with follow up results of the same group and also with another 27 subjects of Group B taken as control.
Results: The results showed improved myocardial functions, improved lipid profile picture and highly significant reduction of Intima-media thickness of Common carotid artery examined with High resolution B-mode ultrasonography. Mean values of Intima-media thickness (mm) in case of experimental group were 0.92±0.11 at baseline and 0.84±0.10 at follow up. These results in control group at baseline were 0.93±0.12 and at follow up were 0.96±0.15. Data is statistically highly significant (p<0.001) in case of experimental group and not significant (p>0.05) in case of control group.
Conclusion: The results of study have clearly reflected that these compounds were able to reduce atherosclerotic plaque present in major and minor arteries.
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References
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