A comparison of platelet parameters in type -2 diabetics, pre-diabetics and normal subjects
Abstract
Introduction: Diabetes Mellitus is a global pandemic disease. The increased platelet activity is emphasized to play a role in the development of vascular complications of the metabolic disorder. Mean platelet volume (MPV) is an indicator of average size and activity of platelets. This study is conducted to compare the platelet parameters in diabetics, pre-diabetics and normal subjects and to find correlation between glycemic control determinants (fasting plasma glucose) and platelet parameters (MPV, platelet count, platelet distribution width) in all the three groups and to correlate the duration of diabetes with MPV.
Material and Methods: Total of 300 subjects (100 subjects in each group) were enrolled in the study. Sample for glucose estimation and platelet parameters were collected and estimation was carried out by the auto-analyzers. The statistical evaluation is done using SPSS version 22. Analysis of variance (ANOVA) and Pearson's correlation test are used to compare the variables and to see the correlation between the different variables respectively.
Result: MPV a marker of platelet function and activation, is significantly higher in patients with type -2 diabetes mellitus than in control and pre-diabetic group with p- value <0.001 which is highly significant. FPG shows no correlation with platelet count and platelet distribution width. Also no correlation was seen between MPV and duration of diabetes.
Conclusion: MPV can be used as a simple and cost effective tool to monitor the progression and control of diabetes and thereby preventing impending acute vascular events in health care centres.
Downloads
References
2. Demirtune R,Duman D ,Basar M ,Bilgi M ,Teomete M ,Garip T .The relationship between gylcemic control and platelet activity in type 2 diabetes mellitus.J Diabetes complications 2009;23:89-94.
3. Update 2014 International Diabetic Federation [IDF] retrieved 29 nov 2014.
4. Williams textbook of endocrinology (12 th edition),Philadelphia;Elsevier/Saunders pp 1371-1435.
5. Shi,Yusnki,Hu,Frank B. The global implication of diabetes and cancer. The Lancet 3831947-8 doi 10.1016/SO140-6736(14) 60886-2 PMID 23245607.
6. Papanas N, Symeonidis G, Maltezos E et al. Mean platelet volume in patients with type 2 diabetes mellitus.
Platelets. 2004 Dec;15(8):475-8.
7. Sharpe PC , Trinick T. Mean platelet volume in diabetes mellitus.QJ Med 1993;86:739-42.
8. Wiwanitkit V.Plateletcrit,mean platelet volume,platelet distribution width:its expected values and correlation with parallel red blood cell parameters.Clin Appl Thromb Hemost.2004;10(2):175-178.
9. Tschoepe D,Roesen P,Kaufmann L,Schauseil S,kehrel B,ostermann H et al.evidence of abnormal platelet expression in diabetes mellitus. Eur J Clin Invest.1990;20 (2):166-170.
10. Ebil N,Krugluger W, Strait G,Hopemier P,scherntham G.Improved metabolic control decreases platelet activation marker in patient with type 2 diabetes mellitus.Eur J clin Invest 2004;34(3):205-209.
11. Chu SG,Becker RC ,Berger PB,Bhatt DL et al.Mean platelet volume asa predictor of cardiovascular risk:a systematic review and meta- analysis. J Thromb Haemost 2010;8:148-156.
12. O'Malley T,Langhorne P,Elton RA ,Stewart C .Platelet size in stroke patient .Stroke 1995;26:995-9.
13. Sharpe PC ,Trinick T .Mean platelet volume in diabetes mellitus .QJ Med 1993;86:739-42.
14. Standards of Medical Care in Diabetes—2014 | Diabetes Care
15. Zuberi BF ,Akhtar N,Afsarn S .Comparison of mean platelet volume in patient with diabetes mellitus, impaired fasting glucose and non- diabetic subjects.Singapore Med J 2008;49:114-6.
16. Hekimsoy Z ,Payzib B,Ornek T, Kandogam G .Mean platelet volume in type 2 diabetic patient .J Diabetic complications 2004;18:173-6.
17. Ates O,Kiki I ,Bilen H ,Kelep M ,Kocer I ,Kulacoolu DN et at.Association of mean platelet volume with the dergree of retinopathy in patients with Diabetes Mellitus .Eur J Gen Med 2009;6:99-102.
18. Jindal S ,Gupta S,Gupta R,Kakkar A, Singh HV ,Gupta K et al .Platelet indices in diabetes mellitus : indicators of diabetic microvascular complicationd. Hematology 2011;16:86-9.
19. Binita shah ,Daohong sha ,dawei Xie ,Emile R ,Mohler ,jefrey S .Berger.Diabetes Care 2012 ;35:1074-8.
20. Colwell JA,Nesto RW .The platelet in diabetics -focus on prevention of ischemic events.Diabetics care 2003;26:2181-89.
21. Chang HA ,Hwang HS,Park HK ,Chun MY ,Sung JY .The role of mean platelet volume as a predicting factor of asymptomatic coronary artery disease .Koream J Fam Med 2010;31:600-6.
22. Vinik AI,Erbas T ,Park TS ,Nohan R ,Pittenger GL .Platelet dysfunction in type -2 diabetes .Diabetes care 2001;24:476-85.
23. Scheneider DJ .Factors contributing to increased platelet reactivity in people with diabetes Diabetes care 2009;32:525 -7.
24. Kakourons N ,Rade JJ ,Kourliouros A ,Resar JR .Platelet function in patient with diabetes mellitus :from a theoretical to practical perspective .Int J Endocrinol 2011;20:742719.
25. Yngen M , Norhammer A ,Hjemdahl P,Wallein NH .Effects of improved metabolic control on platelet reactivity in patient with type 2 diabetes following coronary angioplasty. Diab Vasc Dis Res 2006;3:52-6.
OAI - Open Archives Initiative
