HLA – B association in psoriasis

  • Dr. Ashwin Anandan Senior Research Fellow, Department of Transfusion Medicine, Sri Ramachandra University, Chennai, India
  • Dr. Krishnamoorthy Radhakrishnan Associate Professor, Department of Transfusion Medicine, Sri Ramachandra University, Chennai, India
  • Dr. Ravindra Prasad Thokala Assistant Professor, Department of Transfusion Medicine, Sri Ramachandra University, Chennai, India
  • Dr. Vinod Kumar Panicker Professor, Department of Transfusion Medicine, Sri Ramachandra University, Chennai, India
  • Dr. Murugan Sundaram Professor, Department of Dermatology, Sri Ramachandra University, Chennai, Tamilnadu, India
Keywords: HLA-B, Psoriasis, Relative Risk, Association

Abstract

Background: Psoriasis is a common skin disorder with prevalence varying from 0% to 11.8% in different population. HLA association with psoriasis is well established with very little information about Indian Population.

Aim: To determine the HLA-B pattern and its association in psoriasis patients.

Materials and Methods: Fifty cases and 50 controls were enrolled in the study. HLA-B typing was done by PCR-SSP method and the results was analyzed and interpreted.

Results: The alleles that were found in higher frequency in the cases than in the controls were – HLA-B*35 (34%), HLA-B*15 (26%), HLA-B*40 (26%) and HLA-B*18(14%).

Conclusion: HLA-B*18 and HLA-B*40 show a strong association with psoriasis.

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References

1. Kaur I, Kumar B, Sharma V K, Kaur S. Epidemiology of Psoriasis in a clinic from North India. Indian J. Dermatol Venerol Leprol. 1986; 52:208-212

2. Braun-Falco O, Christopher E, Ulrich Mrowietz. Structural aspects of initial psoriatic lesions. Arch Derm Forsch.1974;251:95-110

3. Michael P Schon and W Henning Boehncke MD et al. Psoriasis. The New England Journal of Medicine. 2005;352(18):1899-1912

4. Ikaheimo,Silvennoinen-Kassinen ,Karvonen J.Immunogenetics profile of psoriasis vulgaris.Arch Dermatol Res 1996;.288:63-67

5. Gonzaga HF,Torres EA. Both psoriasis and benign migratory glossitis are associated with HLA. Br J Dermatol. 1996;135:368-370

6. Russel TJ, Schultes LM., Kuban DJ., HLA antigen associated with Psoriasis. New Engl. J.Med. 1972;287(15):737-40

7. Chablani UA, Contractor NM,, Gadgil RB. HLA and complement C4 studies in Psoriasis Vulgaris. Natl Med J India. 1992;5:8-11

8. Rani R, Narayanan R, Fernandez MA., Stastany P. Role of HLA B and C allels in the development of Psoriasis in patients from North India. Tissue Antigens. 1998; 51:618-22

9. Pictchappan et al. HLA B57 and DR7 association with psoriasis vulgaris in South India. Tissue Antigens. 1989;34:133-7

10. Ray S C, Singh T, Kaur I, Suri S, Sehgal S, Kaur S. Clinical profile of psoriatic arthropathy. Indian J Dermatol Venerol Leprol. 1990; 56:200-203

11. Shankarkumar Umapathy, R Mitra, Arun Pawar, K Ghosh. HLA –A and HLA-B alleles associated in psoriasis patients from Western India. Ind J Dermatol Venerol Leprol. 2011;56(5):497-500

12. Bedi TR et al. Psoriasis in North India-geographical Variations. Dermatologia. 1977;155:310-314


13. AC Biral, RF Magalhaes, IJ Wastowski, R Simoes, EA Donadi et al. Association of HLA-A,-B,-C genes and TNF microsatellite polymorphism with Psoriasis vulgaris: a study of genetic risk in Brazilian patients. European J Dermatol. 2006;16(5):523-529.

14. Fatma Al-Maamri, Ali Al-Shirawi, DD Banodkar, Suliman Al-Hashmi, Faiza Al-Yahyaae, Mathew Varghese et al. HLA antigens in Omani Psoriasis Vulgaris patients. Oman Journal of Medicine. 2009;24(1):27-32.
How to Cite
1.
Anandan A, Radhakrishnan K, Prasad Thokala R, Kumar Panicker V, Sundaram M. HLA – B association in psoriasis. Int J Med Res Rev [Internet]. 2016May31 [cited 2024Nov.23];4(5):831-3. Available from: https://ijmrr.medresearch.in/index.php/ijmrr/article/view/563
Issue
Vol 4 No 5 (2016): MAY
Section
Original Article