HLA – B association in psoriasis

  • Dr. Ashwin Anandan Senior Research Fellow, Department of Transfusion Medicine, Sri Ramachandra University, Chennai, India
  • Dr. Krishnamoorthy Radhakrishnan Associate Professor, Department of Transfusion Medicine, Sri Ramachandra University, Chennai, India
  • Dr. Ravindra Prasad Thokala Assistant Professor, Department of Transfusion Medicine, Sri Ramachandra University, Chennai, India
  • Dr. Vinod Kumar Panicker Professor, Department of Transfusion Medicine, Sri Ramachandra University, Chennai, India
  • Dr. Murugan Sundaram Professor, Department of Dermatology, Sri Ramachandra University, Chennai, Tamilnadu, India
Keywords: HLA-B, Psoriasis, Relative Risk, Association

Abstract

Background: Psoriasis is a common skin disorder with prevalence varying from 0% to 11.8% in different population. HLA association with psoriasis is well established with very little information about Indian Population.

Aim: To determine the HLA-B pattern and its association in psoriasis patients.

Materials and Methods: Fifty cases and 50 controls were enrolled in the study. HLA-B typing was done by PCR-SSP method and the results was analyzed and interpreted.

Results: The alleles that were found in higher frequency in the cases than in the controls were – HLA-B*35 (34%), HLA-B*15 (26%), HLA-B*40 (26%) and HLA-B*18(14%).

Conclusion: HLA-B*18 and HLA-B*40 show a strong association with psoriasis.

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How to Cite
1.
Anandan A, Radhakrishnan K, Prasad Thokala R, Kumar Panicker V, Sundaram M. HLA – B association in psoriasis. Int J Med Res Rev [Internet]. 2016May31 [cited 2024Dec.23];4(5):831-3. Available from: https://ijmrr.medresearch.in/index.php/ijmrr/article/view/563
Issue
Vol 4 No 5 (2016): MAY
Section
Original Article