Study of serum leptin levels in patients with type 2 diabetes mellitus at a tertiary care centre of central India
Keywords:
Type 2 DM, Leptin, BMI
Abstract
Background: It has been reported that Insulin and leptin share a common central signaling pathway and there might be a possible role of leptin in the etiology of type 2 DM. Studies regarding role of leptin in type 2 DM in central India are lacking.
Aim: This study was conducted with the aim of comparing leptin levels in patients with type 2 DM with apparently healthy controls.
Subjects and Methods: A total of 80 subjects including 40 patients of type 2 DM attending outdoor clinics of MY Hospital and 40 age and sex matched healthy controls. Fasting venous blood sample was analysed for leptin, total cholesterol (TC), triglycerides (TG), HDL-C and fasting blood sugar (FBS). Statistical analysis was performed using SPSS software version 14.
Results: Mean BMI of diabetic group was 32 ± 3.48kg/m2 and that of control group was 28 ± 2.56kg/m2. Leptin levels among diabetic cases were 29.3± 19.3 ng/ml and in non diabetic subjects it was 34.8 ±21.4 ng/ml. The difference in leptin levels between cases and control were statistically significant.
Conclusion: Low leptin levels are associated with type 2 diabetes mellitus independent of changes in BMI.
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References
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25. Haffner SM, Miettinen H, Mykkanen L, Stern MP. Leptin concentrations are associated with higher proinsulin and insulin concentrations but a lower proinsulin/insulin ratio in non- diabetic subjects. Int J Obes Relat Metab Disord 1998; Sep;22(9): 899-905.
26. Panarotto D, Ardilouze JL, Tessier D, Maheux P. The degree of hyperinsulinemia and impaired glucose tolerance predicts plasma leptin concentrations in women only: a new exploratory paradigm. Metabolism 2000; Aug; 49(8): 1055-62.
27. Van Gaal LF, Wauters MA, Mertens IL, Considine RV, De Leeuw IH. Clinical endocrinology of human leptin. Int J Obes Relat Metab Disord 1999; Feb;23(Suppl.1): 29-36.
28. Blaak E. Gender differences in fat metabolism. Curr Opin Clin Nutr Metab Care 2001; Nov;4(6): 499-502.
2. Kraegen EW, Cooney GJ, Ye JM, Thompson AL, Furler SM. The role of lipids in the pathogenesis of muscle insulin resistance and β-cell failure in type II diabetes and obesity. Exp Clin Endocrinol Diabetes 2001;109(Suppl-2):S189–S201.
3. Considine RV, Sinha MK, Heiman ML, et al. Serum immunoreactive-leptin concentrations in normal-weight and obese humans. N Engl J Med. 1996 Feb 1;334(5):292-5.
4. Sivitz WL, Walsh SA, Morgan DA, Thomas MJ, Haynes WG. Effects of leptin on insulin sensitivity in normal rats. Endocrinol 1997; Aug: 138(8):3395–401.
5. Pelleymounter MA, Cullen MJ, Baker MB, Hecht R, Wnters D, Boone T, et al. Effects of the obese gene product on body weight regulation in ob/ob mice. Science 1995; Jul 28;269(5223):540–3.
6. Haffner SM, Stern MP, Miettinen H, Wei M, Gingerich RL. Leptin concentrations in diabetic and non-diabetic Mexican- Americans. Diabetes 1996; Jun; 45(6):822–4.
7. Schwartz MW, Prigeon RL, Kahn SE, Nicolson M, Moore J, Morawiecki A, et al. Evidence that plasma leptin and insulin levels are associated body adiposity via different mechanisms. Diabetes Care 1997; Sep;20(9):1476–81.
8. Burtis CA,Ashwood ER,Bruns DE.Tietz textbook of clinical chemistry and molecular diagnostics;5th ed.Philadelphia,PA: Elsevier 2012:1431
9. Burtis CA,Ashwood ER,Bruns DE.Tietz textbook of clinical chemistry and molecular diagnostics;5th ed.Philadelphia,PA: Elsevier 2012:771-772
10. Burtis CA,Ashwood ER,Bruns DE.Tietz textbook of clinical chemistry and molecular diagnostics;5th ed.Philadelphia,PA: Elsevier 2012:772-773
11. Burtis CA,Ashwood ER,Bruns DE.Tietz textbook of clinical chemistry and molecular diagnostics;5th ed.Philadelphia,PA: Elsevier 2012:773-775
12. Burtis CA,Ashwood ER,Bruns DE.Tietz textbook of clinical chemistry and molecular diagnostics;5th ed.Philadelphia,PA: Elsevier 2012:776
13. Sandoval DA, Davis SN. Leptin: metabolic control and regulation. J Diabetes Complications 2003;Mar-Apr;17(2): 108-13.
14. Liew CF, Seah ES, Yeo KP, Lee KO, Wise SD. Lean, non-diabetic Asian Indians have decreased insulin sensitivity and insulin clearance, and raised leptin compared to Caucasians and Chinese subjects. Int J Obes Relat Metab Disord 2003; Jul; 27(7): 784-9.
15. Abdelgadir M, Elbagir M, Eltom M, Berne C, Ahren B. Reduced leptin concentrations in subjects with type 2 diabetes mellitus in Sudan. Metabolism 2002; Mar; 51(3):304-6.
16. Sayeed MA, Azad Khan AK, Mahtab H. Leptin is reduced in lean subjects with type 2 diabetes in Bangladesh. Diabetes Care 2003; Feb; 26(2): 547.
17. Buyukbese MA, Cetinkaya A, Kocabas R, Guven A, Tarakcioglu M. Leptin levels in obese women with and without type 2 diabetes mellitus. Mediators Inflamm 2004; Dec;13(5-6): 321-5.
18. Haque Z, Lakho R, Chundrigar T, Shahid KU, Mazahir I. Serum leptin levels correlate with leukocyte count in diabetic persons. Ann Abbasi Shaheed Hosp Karachi Med Dent Coll 2004; 9: 510-6.
19. Misra A, Arora N, Mondal S, Pandey RM, Jailkani B, Peshin S, et al. Relation between plasma leptin and anthropometric and metabolic covariates in lean and obese diabetic and hyperlipidaemic Asian Northern Indian subjects. Diabetes Nutr Metab 2001; 14(1):: 18-26.
20. Al-Daghri N, Al-Rubean K, Bartlett WA, Al- Attas O, Jones AF, Kumar S. Serum leptin is elevated in Saudi Arabian patients with metabolic syndrome and coronary artery disease. Diabet Med 2003; Oct; 20(10): 832-7.
21. Montague CT, O'Rahilly S. The perils of portliness: causes and consequences of visceral adiposity. Diabetes 2000; Jun; 49(6): 883-8.
22. Cnop M, Landchild MJ, Vidal J. The concurrent accumulation of intra-abdominal and subcutaneous fat explains the association between insulin resistance and plasma leptin concentrations: distinct metabolic effects of two fat compartments. Diabetes 2002; Apr; 51(4): 1005-15.
23. Ahren B, Larsson H, Wilmhansson C, Nasman B, Olsson T. Regulation of circulating leptin in humans. Endocrine 1997; Aug;7(1): 1–8.
24. Mohamed-Ali V, Pinkney JH, Panahloo A, Goodrick S, Coppack SW, Yudkin JS. Relationships between plasma leptin and insulin concentrations, but not insulin resistance, in non-insulin-dependent (type 2) diabetes mellitus. Diabet Med 1997; May; 14(5): 376- 80.
25. Haffner SM, Miettinen H, Mykkanen L, Stern MP. Leptin concentrations are associated with higher proinsulin and insulin concentrations but a lower proinsulin/insulin ratio in non- diabetic subjects. Int J Obes Relat Metab Disord 1998; Sep;22(9): 899-905.
26. Panarotto D, Ardilouze JL, Tessier D, Maheux P. The degree of hyperinsulinemia and impaired glucose tolerance predicts plasma leptin concentrations in women only: a new exploratory paradigm. Metabolism 2000; Aug; 49(8): 1055-62.
27. Van Gaal LF, Wauters MA, Mertens IL, Considine RV, De Leeuw IH. Clinical endocrinology of human leptin. Int J Obes Relat Metab Disord 1999; Feb;23(Suppl.1): 29-36.
28. Blaak E. Gender differences in fat metabolism. Curr Opin Clin Nutr Metab Care 2001; Nov;4(6): 499-502.
CITATION
DOI: 10.17511/ijmrr.2016.i05.24
Published: 2016-05-31
How to Cite
1.
Lohokare R, Bansal A, Kothari V, Dey Sarkar P, Gupta A. Study of serum leptin levels in patients with type 2 diabetes mellitus at a tertiary care centre of central India. Int J Med Res Rev [Internet]. 2016May31 [cited 2024Apr.20];4(5):798-02. Available from: https://ijmrr.medresearch.in/index.php/ijmrr/article/view/559
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