Pattern of Serum Vitamin D in Hospitalised Patients: A Retrospective Study
Keywords:
Vitamin D, Hypovitaminosis D, Diabetes, Hypertension
Abstract
Background: To find out the prevalence of vitamin D deficiency in patients hospitalised in two tertiary care centres for various ailments in Eastern Bihar and North Bengal.
Methods: Hospitalised patients in MGM Medical College, Kishanganj, Bihar and Medical North Bengal Clinic, Siliguri, West Bengal (Jan 2014 to Dec 2014) who underwent blood sampling for vitamin D estimation in their work up for various ailments were included in the study.
Result: Out of 108 patients, 65 were female and 43 were male in the age group ranging from 1 month to 85 years. Maximum number of patients was in the age group of 41 to 60 years. Seventy two percent patients had low vitamin D levels with 54.63% having frank deficiency and 17.59% had insufficient levels. Diabetes mellitus and/or hypertension were the most common diseases associated with hypovitaminosis D followed by diseases of respiratory system.
Conclusion: Vitamin D deficiency was seen in 72 % of the subjects with female preponderance. No age was spared as the age of the subjects ranged from 1 month to 85 years with majority in the 41 to 60 years age group. Among subjects with hypovitaminosis D, diabetes mellitus and /or hypertension were the most commonly encountered diseases.
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References
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24. Bucher HC, Cook RJ, Guyatt GH, Lang JD, Cook DJ, Hatala R. Effects of dietary calcium supplementation on blood pressure: A meta analysis of randomized controlled trials. JAMA. 1996 Apr 3; 275(13): 1016-1022.
25. Appel LJ, Moore TJ, Obarzanek E, Vollmer WM, Svetkey LP, Sacks FM. A clinical trial of the effects of dietary patterns on blood pressure. N Engl J Med. 1997 Apr 17; 336(16): 1117-1124.
2. Ritu G, Gupta A. Vitamin D deficiency in India: Prevalence, Causalities and Interventions. Nutrients. 2014 Feb; 6(2): 729-75. doi: 10.3390/nu6020729.
3. Londhey V. Vitamin D deficiency: Indian Scenario. JAPI. 2011 Nov; 59: 695-696.
4. Holick MF. Vitamin D: A millennium perspective. J Cell Biochem. 2003 Feb 1; 88(2): 296-307.
5. MacDonald P. Molecular biology of the Vitamin D receptor. In: Holick MF (ed). Vitamin D: Physiology, Molecular biology and Clinical applications. Totowa (NJ, USA): Human Press; 1999. p. 109-28.
6. Holick MF. Vitamin D deficiency. N Engl J Med. 2007 Jul 19; 357(3): 266-81.
7. Chapuy MC, Schott AM, Garnero P, Hans D, Delmas PD, Meunier PJ. Healthy elderly French women living at home have secondary hyperparathyroidism and high bone turnover in winter. J Clin Endocrinol Metab 1996 Mar; 81(3): 1129-33.
8. Dawson-Hughes B, Heaney RP, Holick MF, Lips P, Meunier PJ, Vieth R. Estimates of optimal vitamin D status. Osteoporos Int. 2005 Jul; 16(7): 713-6 (editorial).
9. Malabanan A, Veronikis IE, Holick MF. Redefining vitamin D insufficiency. Lancet 1998 Mar 14; 351(9105): 805-6.
10. Holick MF, Siris ES, Binkley N et al. Prevalence of vitamin D inadequacy among post menopausal North American women receiving osteoporosis therapy. J Clin Endocrinol Metab. 2005 Jun; 90(6): 3215-24.
11. Heaney Robert P. Vitamin D in health and disease. Clin J Am Soc Nephrol. 2008 Sep; 3(5): 1535-1541. doi: 10.2215/CJN.01160308.
12. Feskanich D, Ma J, Fuchs CS, Kirkner GJ, Hankinson SE, Hollis BW et al. Plasma vitamin D metabolites and risk of colorectal cancer in women. Cancer Epidemiol Biomarkers Prev. 2004 Sep; 13(9): 1501-1508.
13. Ahonen MH, Tenkanen L, Teppo L, Hakama M, Tuohimaa P. Prostate cancer risk and prediagnostic serum 25 hydroxyvitamin D levels (Finland). Cancer Causes control. 2000 Oct; 11(9): 847-852.
14. Gorham ED, Garland CF, Garland FC, Grant WM, Mohr SB, Lipkin M et al. Vitamin D and prevention of colorectal cancer. J Steroid Biochem Mol Biol. 2005 Oct; 97(1-2): 179-194.
15. Abbas S, Linseisen J, Slanger T, Kropp S, Mutschelknauss EJ, Flesch-Janys D et al. Serum 25 hydroxyvitamin D and risk of post menopausal breast cancer: Results of a large case-control study. Carcinogenesis. 2008 Jan; 29(1): 93-9.
16. Liu PT, Stenger S, Li H, Wenzel L, Tan BH, Krutzik S. Toll-like receptor triggering of a vitamin-mediated human antimicrobial response. Science. 2006 Mar 24; 311(5768): 1770-1773.
17. Cantorna MT, Mahon BD: Mounting evidence for vitamin D as an environmental factor affecting autoimmune disease prevalence. Exp Bio Med (Maywood). 2004 Dec; 229(11): 1136-1142.
18. Scragg R, Sowers M, Bell C: Serum 25 hydroxyvitamin D, diabetes, and ethinicity in the Third National Health and Nutrition Examination Survey. Diabetes Care. 2004 Dec; 27(12): 2813-2818.
19. Chiu KC, Chu A, Go VL, Saad MF : Hypovitaminosis D is associated with insulin resistance and beta cell dysfunction. Am J Clin Nutr. 2004 May; 79(5): 820-825.
20. Hypponen E, Laara E, Reunanen A, Jarvelin M-J,Virtanen SM. Intake of vitamin D and risk of type 1 diabetes: A birth-cohort study. Lancet. 2001 Nov 3; 358(9292): 1500-1503.
21. Forman JP, Giovanncci E, Holmes MD, Bischoff-Ferrari HA, Tworoger SS, Willett WC et al. Plasma 25 hydroxyvitamin D levels and risk of incident hypertension. Hypertension. 2007 May; 49(5): 1063-1069.
22. Wang TJ, Pencina MJ, Booth SL, Jacques PF, Ingelsson E, Lainer K. Vitamin D deficiency and risk of cardiovascular disease. Circulation. 2008 Jan 29; 117(4): 503-511. doi: 10.1161/CIRCULATIONAHA.107.706127.
23. Bucher HC, Guyatt GH, Cook RJ, Hatala R, Cook DJ, Lang JD. Effect of calcium supplementation on pregnancy-induced hypertension and preeclampsia. JAMA. 1996 Apr 10; 275(14): 1113-1117. doi: 10.1001/jama.1996.03530380055031.
24. Bucher HC, Cook RJ, Guyatt GH, Lang JD, Cook DJ, Hatala R. Effects of dietary calcium supplementation on blood pressure: A meta analysis of randomized controlled trials. JAMA. 1996 Apr 3; 275(13): 1016-1022.
25. Appel LJ, Moore TJ, Obarzanek E, Vollmer WM, Svetkey LP, Sacks FM. A clinical trial of the effects of dietary patterns on blood pressure. N Engl J Med. 1997 Apr 17; 336(16): 1117-1124.
CITATION
DOI: 10.17511/ijmrr.2016.i05.19
Published: 2016-05-31
How to Cite
1.
Chhetri N, Chhetri A, Mukherjee A, Bhattacharya GC, Sen S, Kumar A. Pattern of Serum Vitamin D in Hospitalised Patients: A Retrospective Study. Int J Med Res Rev [Internet]. 2016May31 [cited 2024Nov.23];4(5):775-80. Available from: https://ijmrr.medresearch.in/index.php/ijmrr/article/view/556
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