Lipid profile level in oral cancer and its significance on histological grade
Keywords:
Lipid Profile, Oral Squamous cell Carcinoma
Abstract
Introduction: Oral cancer is one of the commonest cancer in India. Its early detection can prevent morbidity and motality. Aim of this study is to estimate the lipid profile level in oral cancer and its significance on histopathological grade.
Material and method: 70 patients with established oral squamous cell carcinoma were taken in the study and their lipid profile analysed.
Result: lipid profile had an inverse relationship with oral cancer with no significant relation with histopathological grade.
Conclusion: lipid profile estimation is a cost effective method to detect oral cancer.
Downloads
Download data is not yet available.
References
1. Day TA, Davis BK, Gillespie MB, Joe JK, Kibbey M, Martin-Harris B, Neville B, Richardson MS, Rosenzweig S, Sharma AK, Smith MM, Stewart S, Stuart RK. Oral cancer treatment. Curr Treat Options Oncol. 2003 Feb;4(1):27-41.
2. NIH fact sheets. Oral Cancer.Assessed at :http://report.nih.gov/nihfactssheets/viewfactsheet.aspx?csid=106.
3. Kumar P, Augustine J, Urs AB, Arora S, Gupta S, Mohanty VR. Serum lipid profile in oral cancer and leukoplakia: correlation with tobacco abuse and histological grading. J Cancer Res Ther. 2012 Jul-Sep;8(3):384-8. doi: 10.4103/0973-1482.103517.
4. Cheng B, Rhodus NL, Williams B, Griffin RJ. Detection of apoptotic cells in whole saliva of patients with oral premalignant and malignant lesions: a preliminary study. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2004 Apr;97(4):465-70.
5. Gupta S,Gupta S. Indian J of dentistry Alteration in serum lipid. Profile patterns in oral cancer and oral precancerous lesions and conditions-a clinical study.. 2011;2(2):1-7.
6. Schatzkin A, Hoover RN, Taylor PR, et al. Cancer Res. Site-specific analysis of total serum cholesterol and incident cancer in the National Health and Nutrition Examination Survey I Epidemiologic Follow-up Study.1988 Jan 15;48(2):452-8.
7. Rose G, Shipley MJ. Plasma lipids and mortality: a source of error. Lancet. 1980 Mar 8;1(8167):523-6.
8. Gilbert HS, Ginsberg H, Fagerstrom R, Brown WV. Characterization of hypocholesterolemia in myeloproliferative disease. Relation to disease manifestations and activity. Am J Med. 1981 Oct;71(4):595-602.
9.Singh S, Ramesh V, Premalatha B, Prashad KV, Ramadoss K. Alterations in serum lipid profile patterns in oral cancer. J Nat Sci Biol Med. 2013 Jul;4(2):374-8. doi: 10.4103/0976-9668.116994.
10. Bailwad SA, Singh N, Jani DR, Patil P, Singh M, Deep G, Singh SAlterations in serum lipid profile patterns in oral cancer: correlation with histological grading and tobacco abuse. Oral Health Dent Manag. 2014 Sep;13(3):573-9.
11. Sherubin EJ, Khannan KS, Kumar DN et al J Oral Maxillofac pathol. Estimation of plasma lipids and its significance on histopathological grades in oral cancer. Prognostic significance an original research. 2013: 17:4-9.
12. Patel PS, Shah MH, Jha FP, Raval GN, Rawal RM, Patel MM, Patel JB, Patel DD. Alterations in plasma lipid profile patterns in head and neck cancer and oral precancerous conditions. Indian J Cancer. 2004 Jan-Mar;41(1):25-31.
13. Sabine JR, Cholesterol, New York;1977.
14. Peter A.Mayer,Harper’s Biochemistry,2000 edition,p-285,Appleton and Lange Publication.
15. Eichholzer M, Stähelin HB, Gutzwiller F, Lüdin E, Bernasconi F. Association of low plasma cholesterol with mortality for cancer at various sites in men: 17-y follow-up of the prospective Basel study. Am J Clin Nutr. 2000 Feb;71(2):569-74.
16. Feinleib M. Review of the epidemiological evidence for a possible relationship between hypocholesterolemia and cancer. Cancer Res. 1983 May;43(5 Suppl):2503s-2507s.
17. Peto R, Doll R, Buckley JD, Sporn MB. Can dietary beta-carotene materially reduce human cancer rates? Nature. 1981 Mar 19;290(5803):201-8.
18. Halton JM, Nazir DJ, McQueen MJ, Barr RD. Blood lipid profiles in children with acute lymphoblastic leukemia. Cancer. 1998 Jul 15;83(2):379-84.
19. Budd D, Ginsberg H. Cancers. Hypocholesterolemia in Acute myelogenous leukemia. Association between disease activity and plasma low density lipoprotein cholesterol concentrations 1986;58:1361-5.
20. Dessi S, Batetta B, Pulisci D, Spano O, Cherchi R, Lanfranco G, Tessitore L, Costelli P, Baccino FM, Anchisi C, et al. Altered pattern of lipid metabolism in patients with lung cancer. Oncology. 1992;49(6):436-41.
21. Saini AS. Text book of biochemistry. 2nd edition,1995,CBS Publisers, New Delhi.
22. Lohe VK, Degwekar SS, Bhowate RR, Kadu RP, Dangore SB. Evaluation of correlation of serum lipid profile in patients with oral cancer and precancer and its association with tobacco abuse. J Oral Pathol Med. 2010 Feb;39(2):141-8. doi: 10.1111/j.1600-0714.2009.00828.x. Epub 2009 Dec 7.
23. Ames BN. Dietary carcinogens and anticarcinogens. Oxygen radicals and degenerative diseases. Science. 1983 Sep 23;221(4617):1256-64.
24. Choi MA, Kim BS, Yu R. Serum antioxidative vitamin levels and lipid peroxidation in gastric carcinoma patients. Cancer Lett. 1999 Feb 8;136(1):89-93.
25. Raval GN, Patel DD, Sainger RN, Shah MH, Shah JS, Patel MM, et al. Asian Pacific J Cancer Prev. A study of various sociodemographic factors and plasma vitamin levels in oral and pharyngeal cancer in Gujarat, India. 2001;2:215-24.
2. NIH fact sheets. Oral Cancer.Assessed at :http://report.nih.gov/nihfactssheets/viewfactsheet.aspx?csid=106.
3. Kumar P, Augustine J, Urs AB, Arora S, Gupta S, Mohanty VR. Serum lipid profile in oral cancer and leukoplakia: correlation with tobacco abuse and histological grading. J Cancer Res Ther. 2012 Jul-Sep;8(3):384-8. doi: 10.4103/0973-1482.103517.
4. Cheng B, Rhodus NL, Williams B, Griffin RJ. Detection of apoptotic cells in whole saliva of patients with oral premalignant and malignant lesions: a preliminary study. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2004 Apr;97(4):465-70.
5. Gupta S,Gupta S. Indian J of dentistry Alteration in serum lipid. Profile patterns in oral cancer and oral precancerous lesions and conditions-a clinical study.. 2011;2(2):1-7.
6. Schatzkin A, Hoover RN, Taylor PR, et al. Cancer Res. Site-specific analysis of total serum cholesterol and incident cancer in the National Health and Nutrition Examination Survey I Epidemiologic Follow-up Study.1988 Jan 15;48(2):452-8.
7. Rose G, Shipley MJ. Plasma lipids and mortality: a source of error. Lancet. 1980 Mar 8;1(8167):523-6.
8. Gilbert HS, Ginsberg H, Fagerstrom R, Brown WV. Characterization of hypocholesterolemia in myeloproliferative disease. Relation to disease manifestations and activity. Am J Med. 1981 Oct;71(4):595-602.
9.Singh S, Ramesh V, Premalatha B, Prashad KV, Ramadoss K. Alterations in serum lipid profile patterns in oral cancer. J Nat Sci Biol Med. 2013 Jul;4(2):374-8. doi: 10.4103/0976-9668.116994.
10. Bailwad SA, Singh N, Jani DR, Patil P, Singh M, Deep G, Singh SAlterations in serum lipid profile patterns in oral cancer: correlation with histological grading and tobacco abuse. Oral Health Dent Manag. 2014 Sep;13(3):573-9.
11. Sherubin EJ, Khannan KS, Kumar DN et al J Oral Maxillofac pathol. Estimation of plasma lipids and its significance on histopathological grades in oral cancer. Prognostic significance an original research. 2013: 17:4-9.
12. Patel PS, Shah MH, Jha FP, Raval GN, Rawal RM, Patel MM, Patel JB, Patel DD. Alterations in plasma lipid profile patterns in head and neck cancer and oral precancerous conditions. Indian J Cancer. 2004 Jan-Mar;41(1):25-31.
13. Sabine JR, Cholesterol, New York;1977.
14. Peter A.Mayer,Harper’s Biochemistry,2000 edition,p-285,Appleton and Lange Publication.
15. Eichholzer M, Stähelin HB, Gutzwiller F, Lüdin E, Bernasconi F. Association of low plasma cholesterol with mortality for cancer at various sites in men: 17-y follow-up of the prospective Basel study. Am J Clin Nutr. 2000 Feb;71(2):569-74.
16. Feinleib M. Review of the epidemiological evidence for a possible relationship between hypocholesterolemia and cancer. Cancer Res. 1983 May;43(5 Suppl):2503s-2507s.
17. Peto R, Doll R, Buckley JD, Sporn MB. Can dietary beta-carotene materially reduce human cancer rates? Nature. 1981 Mar 19;290(5803):201-8.
18. Halton JM, Nazir DJ, McQueen MJ, Barr RD. Blood lipid profiles in children with acute lymphoblastic leukemia. Cancer. 1998 Jul 15;83(2):379-84.
19. Budd D, Ginsberg H. Cancers. Hypocholesterolemia in Acute myelogenous leukemia. Association between disease activity and plasma low density lipoprotein cholesterol concentrations 1986;58:1361-5.
20. Dessi S, Batetta B, Pulisci D, Spano O, Cherchi R, Lanfranco G, Tessitore L, Costelli P, Baccino FM, Anchisi C, et al. Altered pattern of lipid metabolism in patients with lung cancer. Oncology. 1992;49(6):436-41.
21. Saini AS. Text book of biochemistry. 2nd edition,1995,CBS Publisers, New Delhi.
22. Lohe VK, Degwekar SS, Bhowate RR, Kadu RP, Dangore SB. Evaluation of correlation of serum lipid profile in patients with oral cancer and precancer and its association with tobacco abuse. J Oral Pathol Med. 2010 Feb;39(2):141-8. doi: 10.1111/j.1600-0714.2009.00828.x. Epub 2009 Dec 7.
23. Ames BN. Dietary carcinogens and anticarcinogens. Oxygen radicals and degenerative diseases. Science. 1983 Sep 23;221(4617):1256-64.
24. Choi MA, Kim BS, Yu R. Serum antioxidative vitamin levels and lipid peroxidation in gastric carcinoma patients. Cancer Lett. 1999 Feb 8;136(1):89-93.
25. Raval GN, Patel DD, Sainger RN, Shah MH, Shah JS, Patel MM, et al. Asian Pacific J Cancer Prev. A study of various sociodemographic factors and plasma vitamin levels in oral and pharyngeal cancer in Gujarat, India. 2001;2:215-24.
CITATION
DOI: 10.17511/ijmrr.2016.i05.08
Published: 2016-05-31
How to Cite
1.
Mallik M, Mallick S, Kumar M, Kumar Bariar N. Lipid profile level in oral cancer and its significance on histological grade. Int J Med Res Rev [Internet]. 2016May31 [cited 2024Dec.23];4(5):713-6. Available from: https://ijmrr.medresearch.in/index.php/ijmrr/article/view/545
Issue
Section
Original Article
OAI - Open Archives Initiative
