Oral Cavity Malignancies : A clinicopathological study
Abstract
Introduction: Oral cancers are the commonest of head and neck tumours. They share common etiological factors, which are often the personal habits of the patients. Human papillomavirus is increasingly being reported in patients with oral malignancies, especially in Western population. However in India, smoking, alcohol consumption and tobacco chewing are the common etiological factors.
Material and Method: The present study comprises of 379 patients who attended the out patient department or were admitted in the wards of associated hospital of N.S.C.B. Medical College, Jabalpur during the period from July 2003 to July 2005 with the presenting complaint of Tumour/Mass in Head and Neck region. Out of 379 patients of Tumour/Mass in Head and Neck region, 213 patients were having tumour / mass in the oral cavity. Tissue biopsy for histopathological examination was done in all cases.
Results: On histopathological examination of oral cavity tumours , benign tumours were common in females while Majority of the patients of malignancy were males, highest incidence of malignanacy was seen in age group (55-75) years. Incidence of oral malignancy was predominantly more in cheek (buccal mucosa) it constitutes 80 cases (42.8 percent) followed by tongue 42 cases (22.5 percent) in alveolus 33 cases (17.6 percent) , in palate 17 cases (9 percent) in lip 11 cases (6 percent) and lowest incidence was seen in floor of mouth 4 cases (2.1 percent), Histologically Squamous cell carcinoma is seen in all cases.
Conclusion: Oral cancers are among the most common malignancies encountered in clinical practice. Males are more commonly affected than females usually in 5th to 7th decade of life. However, there is a rising incidence noted in female patients as they are hardcore tobacco chewers and less educated than men in the rural setup. Oral cancers are also increasing in younger population due to the habit of consuming alcohol and tobacco.
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2. Sanghvi LD, Rao DN, Joshi S. Epidemiology of head and neck cancers. Semin Surg Oncol. 1989;5(5):305-9. [PubMed]
3. Patel MM, Pandya AN. Relationship of oral cancer with age, sex, site distribution and habits. Indian J Pathol Microbiol. 2004 Apr;47(2):195-7. [PubMed]
4. Balaram P, Sridhar H, Rajkumar T, Vaccarella S, Herrero R, Nandakumar A, Ravichandran K, Ramdas K, Sankaranarayanan R, Gajalakshmi V, Muñoz N, Franceschi S. Oral cancer in southern India: the influence of smoking, drinking, paan-chewing and oral hygiene. Int J Cancer. 2002 Mar 20;98(3):440-5. [PubMed]
5. Rodu B, Jansson C. Smokeless tobacco and oral cancer: a review of the risks and determinants. Crit Rev Oral Biol Med. 2004 Sep 1;15(5):252-63. [PubMed]
6. Znaor A, Brennan P, Gajalakshmi V, Mathew A, Shanta V, Varghese C, Boffetta P. Independent and combined effects of tobacco smoking, chewing and alcohol drinking on the risk of oral, pharyngeal and esophageal cancers in Indian men. Int J Cancer. 2003 Jul 10;105(5):681-6. [PubMed]
7. Yarbrough WG, Aprelikova O, Pei H, Olshan AF, Liu ET. Familial tumor syndrome associated with a germline nonfunctional p16INK4a allele. J Natl Cancer Inst. 1996 Oct 16;88(20):1489-91. [PubMed]
8. SHANTA V, KRISHNAMURTHI S. Further study in aetiology of carcinomas of the upper alimentary tract. Br J Cancer. 1963 Mar;17:8-23. [PubMed]
9. PADMAVATHY G, REDDY DJ. Aetiological factors of carcinoma of the mouth and pharynx in Guntur. J Indian Med Assoc. 1960 Feb 1;34:84-8. [PubMed]
10. Kamat A.R, Kukure A.P, Yeole B.B. Population based cancer registery, Mumbai . Indian cancer society Mumbai ( Bombay), Indidual Registery Data; 1990-1996. [PubMed]
11. Kurtulmaz SY, Erkal HS, Serin M, Elhan AH, Cakmak A. Squamous cell carcinomas of the head and neck: descriptive analysis of 1293 cases. J Laryngol Otol. 1997 Jun;111(6):531-5. [PubMed]
12. S. Kanhere, S. Surange, R. Dikshit, A Shrivastava. Population Based cancer registery Bhopal: Indidual registery data (1990-1996). [PubMed]
13. PAYMASTER JC. Some observations on oral and pharyngeal carcinomas in the State of Bombay. Cancer. 1962 May-Jun;15:578-83. [PubMed]
14. Wahi PN. The epidemiology of oral anc oropharyngeal cancer. A report of the study in Mainpuri district, Uttar Pradesh, India. Bull World Health Organ. 1968;38(4):495-521. [PubMed]
15. Martin H. : Cancer of the gums. American Journal of surgery. 1941; 57: 765-806.18.Wahi PN, Lahiri B, Kehar U, Arora S. Oral and oropharyngeal cancers in North India. Br J Cancer. 1965 Dec;19(4):627-41.
16. Wahi PN, Lahiri B., Kehar U. & Arora S. Oral & Oropharyngeal Cancers in North India. ,Br. J. of Cancer. 1965; 19 (4): 627-641. [PubMed]
17. Mashberg A, Boffetta P, Winkelman R, Garfinkel L. Tobacco smoking, alcohol drinking, and cancer of the oral cavity and oropharynx among U.S. veterans. Cancer. 1993 Aug 15;72(4):1369-75.