B+Myeloid MPAL: boys have it all?
Abstract
Background: MPAL are rare, accounts 4% of acute leukemias .B+MYELOID are extremely rare. There is not much information on biologic features of these strange leukemias. Present study from Kidwai state cancer institute focused on rare types of MPAL, especially B+MYELOID MPAL.
Design and Methods: We classified MPAL based on WHO 2008 classification and summarised diagnostic criteria, cytochemistry, cytogenetics clinical , immunophenotyping and molecular featuresofB+MYELOID MPAL.
Results: Out of 27 MPAL cases reported in the present study 13 cases were B/Myeloid, followed by B+T MPAL ,T+Myeloid .Very few cases of undifferentiated and unclassifiable leukemias were reported. 13 B/myeloid MPAL cases were reported majority of these, to our surprise were seen in children (8 cases) .Only 5 cases were seen in adults. Except a single Ph (+) case in a girl, rest all pediatric B/Myeloid cases, surprisingly were seen in Boys.
Conclusion: Among MPAL high incidence of B+MYELOID 13/27 cases (48%) was noted. High incidence of B/myeloid MPAL was seen in children and majority were Boys (87.5%).All paediatric cases were treated by MCP 841 Protocol &attained remission at end of induction, 5/8 cases were referred for Bone marrow transplant.3 cases are on follow up after median of 6 months and are in remission.
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