A study of liver functions in metabolic syndrome and Type 2 diabetes mellitus
Keywords:
Liver function, Metabolic syndrome, Diabetes mellitus
Abstract
Introduction: Diabetes mellitus is a metabolic disease known by chronic hyperglycemia which results from defective insulin action and secretion. Metabolic syndrome consists of a constellation of metabolic abnormalities that confer increased risk of diabetes mellitus. The aim of the present study was to find out if there is any liver function impairment in patients with metabolic syndrome and type 2 diabetes mellitus.
Materials and Methods: 50 controls, 50 individuals with metabolic syndrome and 50 individuals with type 2 diabetes mellitus were selected by purposive sampling technique. Serum levels of ALT, AST, ALP, total bilirubin and albumin were estimated in controls and cases.
Results: The mean values of serum ALT,AST,ALP, total bilirubin were significantly increased (p<0.001) and serum albumin levels were significantly decreased (p<0.001) in cases compared to controls.
Conclusion: Liver functions are impaired in patients with metabolic syndrome and type 2diabetes mellitus when compared to controls.
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References
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22. Dave A, Kalra P, Gowda B H R, Krishnaswamy M. Association of bilirubin and malondialdehyde levels with retinopathy in type 2 diabetes mellitus. Indian J EndocrinolMetab. 2015 May-Jun; 19(3): 373–377. [PubMed]
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24. G V, P I, Rao DVM. Changes of Plasma Total proteins, Albumin and Fibrinogen in Type 2 Diabetes mellitus- A Pilot study. Indian Journal of Basic & Applied Medical Research; June 2013:7(2): 679-685.
25. Folsom AR, Ma J, Eckfeldt JH ,Nieto FJ et al.Low serum albumin. Association with diabetes mellitus and other cardiovascular risk factors but not with prevalent cardiovascular disease or carotid artery intima-media thickness. The Atherosclerosis Risk in Communities (ARIC) Study Investigators. Ann Epidemiol. 1995 May;5(3):186-91.
2. Kumar JA, Augusthy A. Oxidative stress in metabolic syndrome and Type 2 diabetes mellitus.Biomedicine.2011;31(2):166-170.
3. Villegas R, Xiang YB,ElasyTet al. Liver Enzymes,Type 2 Diabetes and Metabolic Syndrome in Middle-Aged, Urban Chinese Men.Int J ClinExpPathol. 2014; 7(7): 4345–4349.
4. Shaheen A, Khattak S, Khattak AM, Kamal A, Jaffari SA, Sher A. Serum alkaline phosphatase level in patients with type 2 diabetes mellitus and its relation with periodontitis. KUST Med J 2009; 1(2): 51-54. [PubMed]
5. Vítek L. The role of bilirubin in diabetes, metabolic syndrome, and cardiovascular diseases. Front Pharmacol. 2012 Apr 3;3:55. doi: 10.3389/fphar.2012.00055. eCollection 2012. [PubMed]
6. Cho HM, Kim EC, Lee J,Oh SM et al.The Association Between Serum Albumin Levels and Metabolic Syndrome in a Rural Population of Korea. J Prev Med Public Health. 2012 Mar; 45(2): 98–104.
7. Uemura H, Katsuura-Kamano S, Yamaguchi M, Sawachika F, Arisawa K. Serum hepatic enzyme activity and alcohol drinking status in relation to the prevalence of metabolic syndrome in the general Japanese population. PLoS One. 2014 Apr 22;9(4):e95981. doi: 10.1371/journal.pone.0095981. eCollection 2014.
8. Music M, Dervisevic A, Pepic E, Lepara O, Fajkic A, Ascic-Buturovic B, Tuna E. Metabolic Syndrome and Serum Liver Enzymes Level at Patients with Type 2 Diabetes Mellitus. Med Arch. 2015 Aug;69(4):251-5. doi: 10.5455/medarh.2015.69.251-255. Epub 2015 Aug 4.
9. Judi L, Toukan A, Khader Y, Ajlouni K, Khatib MA. Prevalence of elevated hepatic transaminases among Jordanian patients with type 2 diabetes mellitus. Ann Saudi Med. 2010 Jan-Feb;30(1):25-32. doi: 10.4103/0256-4947.59369.
10. Rückert IM, Heier M, Rathmann W, Baumeister SE, Döring A, Meisinger C. Association between markers of fatty liver disease and impaired glucose regulation in men and women from the general population: the KORA-F4-study. PLoS One. 2011;6(8):e22932. doi: 10.1371/journal.pone.0022932. Epub 2011 Aug 5.
11. Oh HJ,Kim TH,SohnYW et al.Association of serum alanine aminotransferase and γ-glutamyltransferase levels within the reference range with metabolic syndrome and nonalcoholic fatty liver disease.Korean J Hepatol. 2011 Mar; 17(1): 27–36.
12. Schneider AL, Lazo M, Ndumele CE, Pankow JS, Coresh J, Clark JM, Selvin E. Liver enzymes, race, gender and diabetes risk: the Atherosclerosis Risk in Communities (ARIC) Study. Diabet Med. 2013 Aug;30(8):926-33. doi: 10.1111/dme.12187. Epub 2013 Apr 12. [PubMed]
13. Paschos P, Paletas K.. Non alcoholic fatty liver disease and metabolic syndrome. Hippokratia. 2009 Jan;13(1):9-19. [PubMed]
14. Cheung C,TanKBC,Lam KSL et al.The Relationship Between Glucose Metabolism,Metabolic Syndrome, and Bone-Specific Alkaline Phosphatase: A Structural Equation Modeling Approach. J ClinEndocrinolMetab, September 2013, 98(9):3856–3863. [PubMed]
15. Goldberg DM, Martin JV, Knight AH.Elevation of serum alkaline phosphatase activity and related enzymes in diabetes mellitus. ClinBiochem. 1977 Feb;10(1):8-11. [PubMed]
16. Krishnamurthy VR, Baird BC, Wei G, Greene T, Raphael K, Beddhu S. Associations of serum alkaline phosphatase with metabolic syndrome and mortality. Am J Med. 2011 Jun;124(6):566.e1-7. doi: 10.1016/j.amjmed.2010.11.030. [PubMed]
17. Maxwell DB, Fisher EA, Ross-Clunis HA 3rd, Estep HL. Serum alkaline phosphatase in diabetes mellitus. J Am Coll Nutr. 1986;5(1):55-9. [PubMed]
18. Yeh SY, Doupis J, Rahangdale S, Horr S, Malhotra A, Veves A. Total serum bilirubin does not affect vascular reactivity in patients with diabetes. Vasc Med. 2009 May;14(2):129-36. doi: 10.1177/1358863X08098273. [PubMed]
19. Takhelmayum R,Thanpari C, and SinghTP.Liver dysfunction in diabetic patients admitted in referral hospital.Bali Med. J. 2014; 3( 3): 122-124.
20. Choudhary M,Vyas RK. A study of liver dysfunction determinants in normal and type 2 diabetic subjects in indian population.Ijsr. 2015 Februvary;2(4):205-207.
21. Shah Nand Sirajwala HB. Serum Bilirubin level in metabolic syndrome.IJBAR ;2014: 5 (3):157-159. [PubMed]
22. Dave A, Kalra P, Gowda B H R, Krishnaswamy M. Association of bilirubin and malondialdehyde levels with retinopathy in type 2 diabetes mellitus. Indian J EndocrinolMetab. 2015 May-Jun; 19(3): 373–377. [PubMed]
23. Rehman A, Zamir S, Bhatti A, Jan SS, Ali S, Wazir F. Evaluation of albuminuria,total plasma proteins and serum albumin in diabetics. Gomal J Med Sci 2012; 10: 198-200.
24. G V, P I, Rao DVM. Changes of Plasma Total proteins, Albumin and Fibrinogen in Type 2 Diabetes mellitus- A Pilot study. Indian Journal of Basic & Applied Medical Research; June 2013:7(2): 679-685.
25. Folsom AR, Ma J, Eckfeldt JH ,Nieto FJ et al.Low serum albumin. Association with diabetes mellitus and other cardiovascular risk factors but not with prevalent cardiovascular disease or carotid artery intima-media thickness. The Atherosclerosis Risk in Communities (ARIC) Study Investigators. Ann Epidemiol. 1995 May;5(3):186-91.
CITATION
DOI: 10.17511/ijmrr.2016.i04.01
Published: 2016-04-30
How to Cite
1.
Augusthy A, Kumar Jeppu A, Sahu S, Jawalekar S, Marakala V, Iqbal S. A study of liver functions in metabolic syndrome and Type 2 diabetes mellitus. Int J Med Res Rev [Internet]. 2016Apr.30 [cited 2024Nov.23];4(4):470-5. Available from: https://ijmrr.medresearch.in/index.php/ijmrr/article/view/504
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