Rare Entities of Mixed Phenotypic Acute Leukemia: Are They Really So Rare? Largest Series of B+T MPAL

  • Dr Raghavendra H .V. Associate Professor of Pathology, Kidwai Memorial Institute of Oncology Bangalore, Karnataka, India
  • Dr Namrata N R Assistant Professor of Pathology, Kidwai Memorial Institute of Oncology Bangalore, Karnataka, India
  • Dr Vijay C. Raghu Assistant Professor, Department Biostatistics, Kidwai Memorial Institute of Oncology Bangalore, Karnataka, India
  • Dr Lakshmiah K Chinnagiriyappa Prof & head Department of Medical Oncology, Kidwai Memorial Institute of Oncology Bangalore, Karnataka, India
DOI: https://doi.org/10.17511/ijmrr.2016.i03.21
Keywords: Acute leukemias of ambiguous lineage, Mixed phenotypic acute leukemia, aberrant antigens, Lymphoid, cytogenetics, Flow immunophenotyping, MCP 841 Protocol

Abstract

Background: MPAL are rare, accounts 4% of acute leukemias. B+T MPAL are extremely rare. There is no robust information on the clinical and biologic features of these leukemias. Present study from kidwai memorial institute of oncology focused on MPAL rare types, especially B+T MPAL.

Design and Methods: We attempted to classify MPAL, based on WHO 2008 classification and attempted to summarise diagnostic criteria, cytochemistry, immunophenotyping, cytogenetics & clinical features of B+T MPAL.

Results: Most MPAL cases reported were B/Myeloid, followed by B+T MPAL, T+Myeloid , undifferentiated and unclassifiable leukemias respectively.

Conclusion: Among MPAL unusual high incidence of B+T MPAL (38.4%) was noted. Overall median survival was 5 years.

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Rare Entities of Mixed Phenotypic Acute Leukemia: Are They Really So Rare? Largest Series of B+T MPAL
CITATION
DOI: 10.17511/ijmrr.2016.i03.21
Published: 2016-03-31
How to Cite
1.
H .V. R, N R N, C. Raghu V, K Chinnagiriyappa L. Rare Entities of Mixed Phenotypic Acute Leukemia: Are They Really So Rare? Largest Series of B+T MPAL. Int J Med Res Rev [Internet]. 2016Mar.31 [cited 2024Dec.22];4(3):401-6. Available from: https://ijmrr.medresearch.in/index.php/ijmrr/article/view/490
Issue
Vol 4 No 3 (2016): MARCH
Section
Original Article

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