A histopathological study and clinico histopathological correlation of single lesions in leprsoy
Abstract
Background: Leprosy caused by Mycobacterium Leprae is an important public health concern. Single lesions in leprosy are commonly seen in TT, BT and indeterminate leprosy.
Aim: The aim of the present study is to evaluate histopathological features of single lesions in different clinical types of leprosy and evaluate clinico histopathological correlation.
Methods: Scalpel biopsies of single leprosy lesions from all 40 patients were done followed by staining of slides with Haemotoxilin and Eosin stains. A thorough study of histopathological features of slides was done followed clinico- histopathological correlation.
Results: There were 7 cases of indeterminate leprosy, 27 cases of BT type and 6 cases of TT type clinically. There were clinico- histopathological correlations in 32.5% of the total cases. More clinico histopathological correlation was seen among TT type and least correlation was seen among BT type.
Conclusion: There is clinico histopatholgical correlation in 32.5% of the total cases. More correlation is seen TT type of leprosy than in BT type of leprosy in single lesions.
Downloads
References
2. Jopling W.H & Mc Douglell AC: Hand Book if Leprosy : 2011: pp1. [PubMed]
3. [Article in English, French] Global leprosy situation, 2012. Wkly Epidemiol Rec. 2012 Aug 24;87(34):317-28. [PubMed]
4. Chochrene R.G: History of leprosy and its spread throughout the world : In leprosy in theory and practice ;1959 ; pp 1- 6.
5. Parkash O. Classification of leprosy into multibacillary and paucibacillary groups: an analysis. FEMS Immunol Med Microbiol. 2009 Jan; 55(1):1-5. doi: 10.1111/j.1574-695X.2008.00491.x. Epub 2008 Nov 13. [PubMed]
6. Agarwal US, Handa AK, Mathur D, Mehta RD, Mittal A, Dhar N, Mathur NK. Hypopigmented lesions in early leprosy--a clinical and histological study. Indian J Lepr. 1990 Oct-Dec; 62(4):416-21.
7. Liu. Tze- chun; Yen Li-zung, Ye Gan-yun and Dung-Gu-Jung Histology of indeterminate leprosy: Internation Journal of Leprosy 1982; 50 ; 2 ; pp ;172-175.
8. Doull and Rodriguez J.N, Gunito R, Platella FC; A field survey of leprosy in Cibu. International Journal of Leprosy ; 1936 ; 4; pp ; 141 -170.
9. Job CK, Kahkonen ME, Jacobson RR, Hastings RC. Single lesion subpolar lepromatous leprosy and its possible mode of origin. Int J Lepr Other Mycobact Dis. 1989 Mar; 57(1):12-9. [PubMed]
10. Ridley DS. Histological classification and the immunological spectrum of leprosy. Bull World Health Organ. 1974; 51(5):451-65. [PubMed]
11. RIDLEY, D. S. Skin Biopsy in Leprosy . 2nd edn. Basle: CIBA-GEIGY 1985.
12. Ridley DS. Pathology and bacteriology of early lesions in leprosy. Int J Lepr Other Mycobact Dis. 1971 Apr-Jun; 39(2):216-24. [PubMed]
13. Ridley DS. The pathogenesis of the early skin lesion in leprosy. J Pathol. 1973 Nov; 111(3):191-206. [PubMed]
14. Sehgal VN, Rege VL, Reys M. Correlation between clinical and histopathologic classification in leprosy. Int J Lepr Other Mycobact Dis. 1977 Jul-Sep; 45(3):278-80. [PubMed]
15. Jerath VP, Desai SR. Diversities in clinical and histopathological classification of leprosy. Lepr India. 1982 Jan; 54(1):130-4. [PubMed]
16. Meyers W.H, Heggie C D et al; The Ridley Jopling five group classification of Leprosy. Correlation of Classification in 1429 leprosy patients. International Journal of Leprosy ; 1979; 47 ; pp 683-384. [PubMed]
17. Khanolkar V.R, Studies in histology of early leprosy Indian Coun. Med Res. Spec. Rep Ser, 19; pp 1- 18 1951 cited by Ammu Nayar & CK –Job.