Relationship between red cell distribution width and heart failure
Keywords:
Heart failure, Red cell distribution width, Ejection fraction
Abstract
Objective: Red cell distribution width (RDW) has recently been discovered to be a novel prognostic marker in patients with heart failure. There is lack of published reports regarding relationship between RDW and Heart Failure in India. The purpose of this study is to determine whether RDW levels can be used as a prognostic marker in heart failure patients.
Materials and Methods: The study was a Cross-sectional study conducted with sample size of 70 subjects with heart failure and 30 subjects without heart failure were selected for the assessment of RDW.
Results: The mean RDW in patient was 15.763 ± 2.609 and in controls was 13.17± 0.75 respectively. The RDW was higher in the cases compared to controls with p value of <0.001. Of the 44 patients of HFREF, 33 had RDW> 13.6 and 11 of them had RDW ≤ 13.6. When compared this distribution of RDW in HFREF with the controls, the difference was significant with a p value of 0.001. Of the 26 patients of HFPEF, 20 had RDW > 13.6 and 6 had RDW ≤ 13.6. When compared this distribution of RDW with the control group, there was a significant difference with a p value of < 0.001.
Conclusion: RDW is a readily available test and with good prognostic value even when compared with a relatively expensive NT-pro BNP measurement. It can be used as an additional marker for diagnosing heart failure.
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References
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2. Mosterd A, Hoes AW. Clinical epidemiology of heart failure. Heart. 2007 Sep; 93(9):1137-46. [PubMed]
3. Ackerman MJ, Priori SG, Willems S, Berul C, Brugada R, Calkins H et al. HRS/EHRA expert consensus statement on the state of genetic testing for the channelopathies and cardiomyopathies. Europace. 2011 Aug; 13(8):1077-109. doi: 10.1093/europace/eur245.
4. Meta-analysis Global Group in Chronic Heart Failure (MAGGIC). The survival of patients with heart failure with preserved or reduced left ventricular ejection fraction: an individual patient data meta-analysis. Eur Heart J 2012; 33; p1750–1757. [PubMed]
5. M. Morris, F. R. Davey. Basic examination of blood J.B. Henry. Clinical diagnosis and management by laboratory methods (2001), pp.489-499.
6. S.D. Mckenzie. Introduction to anaemia S.D Mckenzie(Ed.), Clinical laboratory haematology, Pearson Pretice-Hall, Saddle River, (2008) pp. 188.
7. Felker GM, Allen LA, Pocock SJ, Shaw LK, McMurray JJ, Pfeffer MA, Swedberg K, Wang D, Yusuf S, Michelson EL, Granger CB; CHARM Investigators. Red cell distribution width as a novel prognostic marker in heart failure: data from the CHARM Program and the Duke Databank. J Am Coll Cardiol. 2007 Jul 3; 50(1):40-7. Epub 2007 Jun 18.
8. Celik A, Koc F, Kadi H, Ceyhan K, Erkorkmaz U, Burucu T, Karayakali M, Onalan O. Relationship between red cell distribution width and echocardiographic parameters in patients with diastolic heart failure. Kaohsiung J Med Sci. 2012 Mar; 28(3):165-72. doi: 10.1016/j.kjms.2011.06.024. Epub 2011 Sep 17.
9. McMurray JJ1, Adamopoulos S, Anker SD, Auricchio A, Böhm M, Dickstein K, et al. ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure 2012: The Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2012 of the European Society of Cardiology. Developed in collaboration with the Heart Failure Association (HFA) of the ESCEur Heart J. 2012 Jul; 33(14):1787-847. doi: 10.1093/eurheartj/ehs104.
10. Roger VL, Go AS, Lloyd-Jones DM, Benjamin EJ, Berry JD, Borden WB, Bravata DM, Dai S, Ford ES, Fox CS, Fullerton HJ, Gillespie C, Hailpern SM, Heit JA,Howard VJ, Kissela BM, Kittner SJ, Lackland DT, Lichtman JH, Lisabeth LD, Makuc DM, Marcus GM, Marelli A, Matchar DB, Moy CS, Mozaffarian D, Mussolino ME, Nichol G, Paynter NP, Soliman EZ, Sorlie PD, Sotoodehnia N, Turan TN, Virani SS, Wong ND, Woo D, Turner MB; American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Heart disease and stroke statistics--2012 update: a report from the American Heart Association. Circulation. 2012 Jan 3;125(1):e2-e220. doi: 10.1161/CIR.0b013e31823ac046. Epub 2011 Dec 15. [PubMed]
11. Chen J, Normand SL, Wang Y, Krumholz HM. National and regional trends in heart failure hospitalization and mortality rates for Medicare beneficiaries, 1998-2008. JAMA. 2011 Oct 19;306(15):1669-78. doi: 10.1001/jama.2011.1474. [PubMed]
12. McMurray JJ, Adamopoulos S, Anker SD, Auricchio A, Böhm M, et al. ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure 2012: The Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2012 of the European Society of Cardiology. Eur J Heart Fail. 2012 Aug;14(8):803-69.
13. Rdw1. Förhécz Z, Gombos T, Borgulya G, Pozsonyi Z, Prohászka Z, Jánoskuti L. Red cell distribution width in heart failure: prediction of clinical events and relationship with markers of ineffective erythropoiesis, inflammation, renal function, and nutritional state. Am Heart J. 2009;158:659–666.
14. Al-Najjar Y, Goode KM, Zhang J, Cleland JG, Clark AL. Red cell distribution width: an inexpensive and powerful prognostic marker in heart failure. Eur J Heart Fail. 2009 Dec; 11(12):1155-62. doi: 10.1093/eurjhf/hfp147.
15. S. Reddy, A. Bahl, and K.K. Talwar; Congestive heart failure in Indians: How do we improve diagnosis & management? ; Indian J Med Res. Nov 2010; 132(5): 549–560.
16. Meta-analysis Global Group in Chronic Heart Failure (MAGGIC). The survival of patients with heart failure with preserved or reduced left ventricular ejection fraction: anindividual patient data meta-analysis. Eur Heart J. 2012 Jul;33(14):1750-7. doi: 10.1093/eurheartj/ehr254. Epub 2011 Aug 6. [PubMed]
17. Al-Najjar Y, Goode KM, Zhang J, Cleland JG, Clark AL. Red cell distribution width: an inexpensive and powerful prognostic marker in heart failure. Eur J Heart Fail. 2009 Dec;11(12):1155-62. doi: 10.1093/eurjhf/hfp147.
18. Das Gupta A, Hegde C, Mistri R. Red cell distribution width as a measure of severity of iron deficiency in iron deficiency anaemia. Indian J Med Res. 1994 Oct;100:177-83. [PubMed]
19. Förhécz Z1, Gombos T, Borgulya G, Pozsonyi Z, Prohászka Z, Jánoskuti L. Red cell distribution width in heart failure: prediction of clinical events and relationship with markers of ineffective erythropoiesis, inflammation, renal function, and nutritional state. Am Heart J. 2009 Oct;158(4):659-66. doi: 10.1016/j.ahj.2009.07.024. Epub 2009 Aug 26.
20. Popescu BA, Andrade MJ, Badano LP, Fox KF, Flachskampf FA et al. European Association of Echocardiography recommendations for training, competence, and quality improvement in echocardiography. Eur J Echocardiogr 2009;10:893-905.
CITATION
DOI: 10.17511/ijmrr.2016.i02.003
Published: 2016-02-29
How to Cite
1.
M G R, KU V. Relationship between red cell distribution width and heart failure. Int J Med Res Rev [Internet]. 2016Feb.29 [cited 2024Apr.25];4(2):144-50. Available from: https://ijmrr.medresearch.in/index.php/ijmrr/article/view/450
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Original Article
OAI - Open Archives Initiative
