Significance of thrombocytopenia in different types of malaria
Abstract
Introduction: Malaria is a major health problem in India. It usually presents with thrombocytopenia, Study was conducted to assess the presence and severity of thrombocytopenia in malaria- fever. This study was done in at tertiary care teaching hospital associated with medical college.
Method: A total of 120 patients with acute febrile illness and positive for malaria parasite were included. They all are positive for malaria parasite on peripheral smear examination with leishmans stain on conventional microscopy. Platelet count was done on a fully automated, hematology analyzer.
Results: Thrombocytopenia was observed in 100% cases of malaria caused by P. Falciparum and 69.79% cases of malaria caused by P Vivax. Overall 85.83% of patients with acute febrile illness due to malaria showed thrombocytopenia.
Conclusion: Thrombocytopenia is a common finding in malaria- fever, but its presence is not a distinguishing feature between Pl. vivax and Pl. falciprum. Our study noted the importance of thrombocytopenia as an indicator of malaria in acute febrile illness.
Downloads
References
2. Faseela TS, Ronald AR, Anita KB, Chaithra SM, Rai Y. Diagnostic Value of Platelet Count in Malaria. J Clin Diagn Res 2011;5:464-6.
3. Khan SA, Ali W. Platelet count in malaria. Pak J Pathol 2008;19;86-8.
4.Rathod DA, Patel V, Kaur AA, Patel VD, Patel DD. Diagnosis of acute malaria by laser based cell counter with comparison of conventional and recent techniques inIndian scenario. Indian J Pathol Microbiol. 2009 Apr-Jun;52(2):185-8.
5. Lathia TB, Joshi R. Can hematological parameters discriminate malaria from nonmalarious acute febrile illness in the tropics? Indian J Med Sci. 2004 Jun;58(6):239-44. [PubMed]
6. Tangpukdee N, Duangdee C, Wilairatana P, Krudsood S. Malaria diagnosis: a brief review. Korean J Parasitol. 2009 Jun;47(2):93-102. doi: 10.3347/kjp.2009.47.2.93. Epub 2009 May 26. [PubMed]
7. Shaikh QH, Ahmad SM, Abbasi A, Malik SA, Sahito AA, Munir SM. Thrombocytopenia in malaria. J Coll Physicians Surg Pak. 2009 Nov;19(11):708-10. doi: 11.2009/JCPSP.708710. [PubMed]
8. Patel U, Ghandi G, Friedman S, Niranjan S. Thrombocytopenia in malaria. J Nati Med Assoc 2004; 96 (9): 1212-1214 http://www.ncbi.nim.nih.gov/pubmed/1548,1750.
9. Jadhav UM, Patkar VS, Kadam NN. Thrombocytopenia in malaria--correlation with type and severity of malaria. J Assoc Physicians India. 2004 Aug;52:615-8. [PubMed]
10. Lathia TB, Joshi R. Can hematological parameters discriminate malaria from nonmalarious acute febrile illness in the tropics? Indian J Med Sci. 2004 Jun;58(6):239-44. [PubMed]
11. Richards MW, Behrens RH, Doherty JF. Short report: hematologic changes in acute, imported Plasmodium falciparum malaria. Am J Trop Med Hyg. 1998 Dec;59(6):859. [PubMed]
12. Oh MD, Shin H, Shin D, Kim U, Lee S, Kim N, Choi MH, Chai JY, Choe K. Clinical features of vivax malaria. Am J Trop Med Hyg. 2001 Aug;65(2):143-6. [PubMed]
13. Lee HK, Lim J, Kim M, Lee S, Oh EJ, Lee J, Oh J, Kim Y, Han K, Lee EJ, Kang CS, Kim BK. Immunological alterations associated with Plasmodium vivax malaria in South Korea. Ann Trop Med Parasitol. 2001 Jan;95(1):31-9. [PubMed]
14. Shah HAS, Ansari IA, Abro G.Y, Shaikh ZA, Kumar A: Mehsar S. To assess the frequency of thrombocytopenia. Quarterly medical channel, 2012;18;68-71.
15. Facer CA, Hematological aspect of malaria: Infection and Hematology. Oxford: Butterworth Heinmann Ltd. 1994:259-94.
16. Beale PJ, Cormack JD, Oldrey TB. Thrombocytopenia in malaria with immunoglobulin (IgM) changes. Br Med J. 1972 Feb 5;1(5796):345-9.