Role of impression surface cytology in ocular surface disorders
Keywords:
Squamous, Impression, Cytology, Neoplasia, Ocular
Abstract
Ocular surface impression cytology is useful, least invasive tool in the diagnosis of various ocular surface disorders like dry eye, xerophthalmia, ocular surface neoplasia etc. Its role in diagnosis of ocular surface squamous neoplasia (OSSN) is well established. This technique has also been shown to have good correlation with histopathological diagnosis. Conjunctival impression cytology involves the removal of superficial epithelial cells of the conjunctiva and their study to make out changes in the conjunctival epithelial cells. These changes can be studied with light microscopy, electron microscopy or using the immunological markers. This article is a retrospective review of English literature articles published on ocular surface impression cytology and its application in various disorders. To achieve this purpose, a detailed online Med line search was done for related publications. The relevant articles were studied and required information was obtained.
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References
1. Egbert PR, Lauber S, Maurice DM. A simple conjunctival biopsy. Am J Ophthalmol. 1977 Dec;84(6):798-801. [PubMed]
2. Adams AD. The morphology of human conjunctival mucus. Arch Ophthalmol. 1979 Apr;97(4):730-4. [PubMed]
3. Marner K. “Snake-like” appearance of nuclear chromatin in conjunctival epithelial cells from patients with keratoconjunctivitis sicca. Acta Ophthalmol (Copenh). 1980 Oct;58(5):849-53.
4. Nelson JD. Ocular surface impressions using cellulose acetate filter material: ocular pemphigoid. Surv Ophthalmol. 1982 Jul-Aug;27(1):67-9. [PubMed]
5. Nelson JD, Havaner VR, Cameron JD. Cellulose acetate impressions of the ocular surface: dry eye states. Arch Ophthalmol. 1983 Dec;101(12):1869-72. [PubMed]
6. Hatchell DL, Sommer A. Detection of ocular surface abnormalities in experimental vitamin A deficiency. Arch Ophthalmol. 1984 Sep;102(9):1389-93. [PubMed]
7. Wittpenn JR, Tseng SCG, Sommer A. Detection of early xerophthalmia by impression cytology. Arch Ophthalmol. 1986 Feb;104(2):237-9. [PubMed]
8. Tseng SCG. Staging of conjunctival squamous metaplasia by impression cytology. Ophthalmol. 1985 Jun;92(6):728-33. [PubMed]
9. Maskin SL, Bode DD. Electron microscopy of impression-acquired conjunctival epithelial cells. Ophthalmol. 1986 Dec;93(12):1518-23.
10. Martinez AJ, Mills MB, Jaceldo KB et al. Standardization of conjunctival impression cytology. Cornea. 1995 Sep;14(5):515-22. [PubMed]
11. Krenzer KL, Freddo TF. Cytokeratin expression in normal human bulbar conjunctiva obtained by impression cytology. Invest Ophthalmol Vis Sci. 1997 Jan;38(1):148-52.
12. Tole DM, McKelvie PA, Daniell M. Reliability of impression cytology for the diagnosis of ocular surface squamous neoplasia employing the bio pore membrane. Br J Ophthalmol. 2001 Feb;85(2):154-8.
13. Nolan GR, Hirst LW, Wright RJ, et al. Application of impression cytology to the diagnosis of conjunctival neoplasms. Diagn Cytopathol. 1994;11(30:246-9.
14. McKelvie PA, Daniell M Impression cytology following mitomycin C therapy for ocular surface squamous neoplasia Br J Ophthalmol 2001;85:1115-9.
15. Nelson JD, Wright JC. Conjunctival goblet cell densities in ocular surface disease. Arch Ophthalmol. 1984 Jul;102(7):1049-51. [PubMed]
16. Tomatir DK, Erda N, Gurlu VP. Effects of different contact lens materials and contact lens-wearing periods on conjunctival cytology in asymptomatic contact lens wearers. Eye Contact Lens. 2008 May;34(3):166-8. doi: 10.1097/ICL.0b013e31815788ea
17. Albeitz JM. Conjunctival histologic findings of dry eye and non-dry eye contact lens wearing subjects. CLAO J. 2001 Jan;27(1):35-40. [PubMed]
18. Galarreta DJ, Corrales RM, Herreras JM et al. Levels of anti-oxidant enzyme genes in conjunctival impression cytology specimens from hydrogel contact lens wearers. Inv Ophthal Vis Sci. 2003;44:e abstracts 3682. [PubMed]
19. Singh M, Singh G, Dwewedi S, Kumar D, Tiwari A, Aggarwal M. Conjunctival impression cytology in xerophthalmia in rural children. Indian J Ophthalmol. 1997 Mar;45(1):25-9. [PubMed]
20. Chowdhary S, Kumar R, Ganguly NK, Kumar L, Naik CK, Walia BNS. Conjunctival impression cytology with transfer (CICT) to detect pre-clinical vitamin A deficiency among slum children in India. Br J Nutr. 1996 May;75(5);785-90.
21. Rahman MM, Mahalanabis D, Wahed MA, Islam M, Habte D, Khaled MA, Alvarez JO. Conjunctival impression cytology fails to detect sub clinical vitamin deficiency in young children. J Nutr. 1995 Jul;125(7):1869-74.
22. Soker S, Nergiz Y, Cakmak S, Aytekin S. Conjunctival impression cytology and bulbar surface epithelium changes in patients with psoriasis. Dicle Tip Dergisi. 2007;34:102-6.
23. Dursun D, Demirhan B, Oto S, Pinar A. Impression cytology of the conjunctival epithelium in patients with chronic renal failure. Br J Ophthalmol. 2004 Nov;84(11):1225-7.
24. Alp BN, karabas L, Bilen N, Talu H, Kaur A, Yanyali A. Evaluation of ocular surface changes on impression cytology in acne vulgaris. Tr J Med Sci. 1999;29:693-6. [PubMed]
25. Kanavi MR, Hosseini B, Javadi M, Rakhshani N, Javadi MA. Impression cytology in eyes with clinical and confocal scan features of acanthamoeba keratitis. J Ophthalmic Vis Res. 2013 Jul;8(3):207-12. [PubMed]
26. Baudouin C, Haouat N, Brignole F, Bayle J, Gastaud J. Immunopathological findings in conjunctival cells using immunofluorescence staining of impression cytology specimens. B J Ophthalmol. 1992 Sep;76(9):545-9.
2. Adams AD. The morphology of human conjunctival mucus. Arch Ophthalmol. 1979 Apr;97(4):730-4. [PubMed]
3. Marner K. “Snake-like” appearance of nuclear chromatin in conjunctival epithelial cells from patients with keratoconjunctivitis sicca. Acta Ophthalmol (Copenh). 1980 Oct;58(5):849-53.
4. Nelson JD. Ocular surface impressions using cellulose acetate filter material: ocular pemphigoid. Surv Ophthalmol. 1982 Jul-Aug;27(1):67-9. [PubMed]
5. Nelson JD, Havaner VR, Cameron JD. Cellulose acetate impressions of the ocular surface: dry eye states. Arch Ophthalmol. 1983 Dec;101(12):1869-72. [PubMed]
6. Hatchell DL, Sommer A. Detection of ocular surface abnormalities in experimental vitamin A deficiency. Arch Ophthalmol. 1984 Sep;102(9):1389-93. [PubMed]
7. Wittpenn JR, Tseng SCG, Sommer A. Detection of early xerophthalmia by impression cytology. Arch Ophthalmol. 1986 Feb;104(2):237-9. [PubMed]
8. Tseng SCG. Staging of conjunctival squamous metaplasia by impression cytology. Ophthalmol. 1985 Jun;92(6):728-33. [PubMed]
9. Maskin SL, Bode DD. Electron microscopy of impression-acquired conjunctival epithelial cells. Ophthalmol. 1986 Dec;93(12):1518-23.
10. Martinez AJ, Mills MB, Jaceldo KB et al. Standardization of conjunctival impression cytology. Cornea. 1995 Sep;14(5):515-22. [PubMed]
11. Krenzer KL, Freddo TF. Cytokeratin expression in normal human bulbar conjunctiva obtained by impression cytology. Invest Ophthalmol Vis Sci. 1997 Jan;38(1):148-52.
12. Tole DM, McKelvie PA, Daniell M. Reliability of impression cytology for the diagnosis of ocular surface squamous neoplasia employing the bio pore membrane. Br J Ophthalmol. 2001 Feb;85(2):154-8.
13. Nolan GR, Hirst LW, Wright RJ, et al. Application of impression cytology to the diagnosis of conjunctival neoplasms. Diagn Cytopathol. 1994;11(30:246-9.
14. McKelvie PA, Daniell M Impression cytology following mitomycin C therapy for ocular surface squamous neoplasia Br J Ophthalmol 2001;85:1115-9.
15. Nelson JD, Wright JC. Conjunctival goblet cell densities in ocular surface disease. Arch Ophthalmol. 1984 Jul;102(7):1049-51. [PubMed]
16. Tomatir DK, Erda N, Gurlu VP. Effects of different contact lens materials and contact lens-wearing periods on conjunctival cytology in asymptomatic contact lens wearers. Eye Contact Lens. 2008 May;34(3):166-8. doi: 10.1097/ICL.0b013e31815788ea
17. Albeitz JM. Conjunctival histologic findings of dry eye and non-dry eye contact lens wearing subjects. CLAO J. 2001 Jan;27(1):35-40. [PubMed]
18. Galarreta DJ, Corrales RM, Herreras JM et al. Levels of anti-oxidant enzyme genes in conjunctival impression cytology specimens from hydrogel contact lens wearers. Inv Ophthal Vis Sci. 2003;44:e abstracts 3682. [PubMed]
19. Singh M, Singh G, Dwewedi S, Kumar D, Tiwari A, Aggarwal M. Conjunctival impression cytology in xerophthalmia in rural children. Indian J Ophthalmol. 1997 Mar;45(1):25-9. [PubMed]
20. Chowdhary S, Kumar R, Ganguly NK, Kumar L, Naik CK, Walia BNS. Conjunctival impression cytology with transfer (CICT) to detect pre-clinical vitamin A deficiency among slum children in India. Br J Nutr. 1996 May;75(5);785-90.
21. Rahman MM, Mahalanabis D, Wahed MA, Islam M, Habte D, Khaled MA, Alvarez JO. Conjunctival impression cytology fails to detect sub clinical vitamin deficiency in young children. J Nutr. 1995 Jul;125(7):1869-74.
22. Soker S, Nergiz Y, Cakmak S, Aytekin S. Conjunctival impression cytology and bulbar surface epithelium changes in patients with psoriasis. Dicle Tip Dergisi. 2007;34:102-6.
23. Dursun D, Demirhan B, Oto S, Pinar A. Impression cytology of the conjunctival epithelium in patients with chronic renal failure. Br J Ophthalmol. 2004 Nov;84(11):1225-7.
24. Alp BN, karabas L, Bilen N, Talu H, Kaur A, Yanyali A. Evaluation of ocular surface changes on impression cytology in acne vulgaris. Tr J Med Sci. 1999;29:693-6. [PubMed]
25. Kanavi MR, Hosseini B, Javadi M, Rakhshani N, Javadi MA. Impression cytology in eyes with clinical and confocal scan features of acanthamoeba keratitis. J Ophthalmic Vis Res. 2013 Jul;8(3):207-12. [PubMed]
26. Baudouin C, Haouat N, Brignole F, Bayle J, Gastaud J. Immunopathological findings in conjunctival cells using immunofluorescence staining of impression cytology specimens. B J Ophthalmol. 1992 Sep;76(9):545-9.
CITATION
DOI: 10.17511/ijmrr.2015.i10.223
Published: 2015-11-30
How to Cite
1.
Gupta S. Role of impression surface cytology in ocular surface disorders. Int J Med Res Rev [Internet]. 2015Nov.30 [cited 2024Nov.19];3(10):1228-33. Available from: https://ijmrr.medresearch.in/index.php/ijmrr/article/view/404
Section
Review Article
OAI - Open Archives Initiative
