Histomorphometry of umbilical cord and perinatal outcome in intrauterine growth restriction

  • Dr Sangeeta S Kotrannavar M.Sc (Medical Anatomy) Research scholar, Department of Anatomy, J N Medical College, KLE University, Belagavi, Karnataka, India
  • Dr Hema A Dhumale MD, Professor, Department of Obstetrics & Gynecology, J N Medical College, KLE University, Belagavi, Karnataka, India
  • Dr Veereshkumar S Shirol MS, Professor, Department of Anatomy, J N Medical College, KLE University, Belagavi, Karnataka, India
  • Dr Rajendra S Humbarwadi M S, Professor, Department of Anatomy, USM- KLE International Medical Programme, Belagavi, Karnataka, India
  • Dr Shivalingappa B Javali M.Sc (Stat), M Phil, Ph D, Associate Professor, Department of Community Medicine, USM- KLE International Medical Programme, Belagavi, Karnataka, India
  • Dr Suresh P Desai M S, Professor, Department of Anatomy, J N Medical College, KLE University, Belagavi, Karnataka, India
DOI: https://doi.org/10.17511/ijmrr.2015.i10.227
Keywords: Histomorphometry, IUGR, Perinatal outcome, Umbilical cord area, Umbilical cord circumference, Umbilical cord diameter

Abstract

Objective: To evaluate the histomorphometry of umbilical cord (UC) in intrauterine growth restricted (IUGR) newborns compared to appropriate for gestational age (AGA) newborns, and secondly to assess its impact on the intrapartum and perinatal outcome.

Materials and Methods: A prospective observational study was conducted at Obstetrics and Gynecology unit of KLES Dr. Prabhakar Kore Hospital and Medical Research Centre, Belagavi. Study involved total 130 UCs of AGA and IUGR newborns. Tissues were fixed in formalin and paraffin embedded sections were examined. For each UC; UC cross sectional area (CSA), UC diameter and UC circumference parameters were measured under microscope with the help of digital image analyzer. Perinatal outcome like gestational age (GA) at delivery, birth weight, mode of delivery, sex of newborn, neonatal outcome and intrapartum complications were recorded. Independent t test was used to compare means and chi-square test for categorical variables.

Results: UC of IUGR newborns had significantly reduced UC area, diameter and circumference as compared to AGA newborns. IUGR newborns were associated with significant difference in GA at delivery, birth weight, neonatal intensive care unit admissions (NICU) and fetal distress. No significant difference was found in mode of delivery, sex of newborn and meconium stained liquor among AGA and IUGR groups.

Conclusion: Assessment of CSAs of UC and its components can be used as early screening tool for fetal growth and it may provide useful information about pregnancy at risk and help in averting poor perinatal outcome.

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CITATION
DOI: 10.17511/ijmrr.2015.i10.227
Published: 2015-11-30
How to Cite
1.
S Kotrannavar S, A Dhumale H, S Shirol V, S Humbarwadi R, B Javali S, P Desai S. Histomorphometry of umbilical cord and perinatal outcome in intrauterine growth restriction. Int J Med Res Rev [Internet]. 2015Nov.30 [cited 2024Apr.26];3(10):1251-6. Available from: https://ijmrr.medresearch.in/index.php/ijmrr/article/view/397
Issue
Vol 3 No 10 (2015): NOVEMBER
Section
Original Article