To evaluate alteration of salivary sodium and potassium level in hypertensive patients with and without medication
Abstract
Aim: to study the alterations of sodium and potassium in saliva with change in blood pressure values and to estimate sodium and potassium level in saliva in controls and hypertensive’s with the comparison and correlation of their changes.
Materials and methods: 58 patients of age group between 30-70 years with 43 hypertensives and 15 controls were examined in medicine department Rajendra Institute of Medical Sciences, Ranchi for a period of about 5 weeks(one month) and unstimulated saliva was collected before and after treatment with antihypertensive drugs.
Results: The hypertensive patients were characterized with significantly elevated levels of potassium ion(p=0.000) and less remarkable increase of sodium ion (p=0.24) after one month treatment as compared to controls. Also the salivary potassium ion was more marked in patients under Atenolol antihypertensive drug.
Conclusions: The result may be related to the hypothesis of chronic adrenergic over stimulation of the salivary glands in hypertensive patients. Salivary concentrations of sodium and potassium ion can be used as a valuable marker and diagnostic aid in hypertensive patients.
Downloads
References
2. Maier H, Coronco MT, Schindler JG, Schmirr M, Juskowa J, Heidland A.The effect of PTH on human parotid and submandibular saliva.. Oxford; Pergamon Press, 1980: 295-300.
3. Mandel ID, Zengo A, Katz R, Wotman S. Effect of adrenergic agents on salivary composition. J Dent Res. 1975 Jun;54 Spec No B:B27-33. [PubMed]
4. Adlin V, Channick BJ, Marks AD. Salivary sodium-potassium ratio and plasma renin activity in hypertension. Circulation. 1969 May;39(5):685-92. [PubMed]
5. G. Mancia, R. Fagard, K. Narkiewicz et al. “ESH/ESC guidelines for the management of arterial hypertension: the task force for the management of arterial hypertension of the European society of hypertension (ESH) and of the European society of cardiology (ESC).Journal of Hypertension 2007;25( 9):1751–1762. Available at: http://www.esh2013.org/wordpress/wp-content/uploads/2013/06/ESC-ESH-Guidelines-2013.pdf.
6. Närhi TO, Meurman JH, Ainamo A. Xerostomia and hyposalivation: causes, consequences and treatment in the elderly. Drugs Aging. 1999 Aug;15(2):103-16. [PubMed]
7. Navazesh M, Brightman VJ, Pogoda JM. Relationship of medical status, medications, and salivary flow rates in adults of different ages. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1996 Feb;81(2):172-6. [PubMed]
8. Parvinen T. Stimulated salivary flow rate, pH and lactobacillus and yeast concentrations in persons with different types of dentition. Scand J Dent Res. 1984 Oct;92(5):412-8. [PubMed]
9. Ben-Aryeh H, Schiller M, Shasha S, Szargel R, Gutman D. Salivary composition in patients with essential hypertension and the effect of Pindolol. J Oral Med. 1981 Jul-Sep;36(3):76-8. [PubMed]
10. G. Mancia, R. Fagard, K. Narkiewicz et al. “ESH/ESC guidelines for the management of arterial hypertension: the task force for the management of arterial hypertension of the European society of hypertension (ESH) and of the European society of cardiology. J of Hypertens 2007; 25( 9): 1751–1762.
11. Rasheed RH. A comparative study between the effects of two different antihypertensive drugs on the salivary flow rate and salivary composition. J College Dentistry 2005;17(1):43-46.
12. Musumeci V, Di Salvo S, Zappacosta B, Zuppi C, Colacicco L, Cherubini P. Salivary electrolytes in treated hypertensives at low or normal sodium diet. Clin Exp Hypertens. 1993 Mar;15(2):245-56. [PubMed]
13. Ben-Aryeh H, Schiller M, Shasha S, Szargel R, Gutman D. Salivary composition in patients with essential hypertension and the effect of Pindolol. J Oral Med. 1981 Jul-Sep;36(3):76-8.
OAI - Open Archives Initiative
