Effect of parachlorophenylalanine, a specific 5-HT depleter on fluoxetine and d-fenfluramine induced penile erections in rats

  • Dr More Kanhaiah Assistant Professor, Dept of Pharmacology, Travancore Medical College, Medicity, Kollam, Kerala, India
  • Dr Vandana M Thorat Professor, Dept of Pharmacology, Krishna Institute of Medical Sciences University Karad, Maharashtra, India
  • Dr Anjali R Shinde Assistant Professor, Dept of Pharmacology, PIMS, Islampur, Maharashtra, India
  • Dr Santosh G Gursale Professor, Dept of Pharmacology, IMSR Medical College, Mayani, Maharashtra, India
DOI: https://doi.org/10.17511/ijmrr.2015.i9.178
Keywords: Fluoxetine (FLU), d-Fenfluramine (d-FEN), Parachlorophenylalanine (PCPA), Penile Erections (PEs), Penile Erections (PEs)Intraperitoneal injection (ip), Metachlorophenylpiperazine (mCPP), 5-Hydroxytriptamine (5-HT)

Abstract

Objective: To determine whether fluoxetine (FLU) induces penile erection (PE) in rats either indirectly via its 5-HT neuronal reuptake inhibiting activity or directly by stimulating the 5-HT2c receptors in the brain.

Method: The effect of pre-treatment with para-Chlorophenylalanine (PCPA) on fluoxetine and d-fenfluramine (d-FEN) induced PEs (Penile erections) was studied in albino rats.

Results: FLU (10mg/kg) and d-FEN (2.5mg/kg) treated groups exhibited a significant increase in number of PEs as compared to their respective control (DW treated) groups. Pre-treatment with PCPA (100mg/kg/day) had no significant effect on the PEs induced by FLU (10mg/kg) but did significantly decrease the PEs induced by d-FEN (2.5 mg/kg).

Conclusion: Our results indicate that pre-treatment with selective 5-HT depleter PCPA (100mg/kg/day) significantly decreased PEs induced by d-FEN (2.5mg/kg) but had no significant effect on the number of PEs induced by FLU (10 mg/kg). This indicates that the PE inducing effect of FLU is probably due to the stimulation of 5HT2C receptors.

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CITATION
DOI: 10.17511/ijmrr.2015.i9.178
Published: 2015-10-31
How to Cite
1.
Kanhaiah M, M Thorat V, R Shinde A, G Gursale S. Effect of parachlorophenylalanine, a specific 5-HT depleter on fluoxetine and d-fenfluramine induced penile erections in rats. Int J Med Res Rev [Internet]. 2015Oct.31 [cited 2024Nov.22];3(9):959-63. Available from: https://ijmrr.medresearch.in/index.php/ijmrr/article/view/351
Issue
Vol 3 No 9 (2015): OCTOBER
Section
Original Article