Antihistaminic Induced Febrile Seizure – An Important association: a Case report
Keywords:
antihistamine, histamine H1 antagonist, febrile seizures
Abstract
The histamine H1 receptor antagonist (antihistamines) are an important class of commonly used medications for the relief of symptoms associated with common cough and cold occurring in children . We report two cases of antihistaminic induced febrile seizure in children below five year. We consider importance of reporting such cases in view of their common usage and propensity to provoke seizure in susceptible children.
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References
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2. Kliegman RM, Stanton BF, Gemelll JW, Schor NF, Behrman RE. Nelson’s Textbook of Pediatrics. 18th ed. New York: Elsevier; 2007.p 1994.
3. Gubser M, Blumberg A, Donati F. Febrile convulsions: assessment of current status. Schweiz Med Wochenschr. 1999 May ;129(17):649–57. [PubMed]
4. Yawata I, Tanaka K, Nakagawa Y, Watanabe Y, Murashima YL, Nakano K. Role of histaminergic neurons in development of epileptic seizures in EL mice. Brain Res Mol Brain Res. 2004 Dec;132(1):13–17. [PubMed]
5. Yokoyama H, Onodera K, Maeyama K, Yanai K, Iinuma K, Tuomisto L, Watanabe T. Histamine levels and clonic convulsions of electrically-induced seizure in mice: the effects of fluoromethylhistidine and metoprine. Naunyn Schmiedebergs Arch Pharmacol.1992 July;346(1):40–45.
6. Fujii Y, Tanaka T, Harada C, Hirai T, Kamei C. Epileptogenic activity induced by histamine H1 antagonists in amygdala-kindled rats. Brain Res. 2003 Nov;991(12):258–61. [PubMed]
7. Murphy K, Delanty N. Drug-induced seizures: general principles in assessment, management and prevention. CNS Drugs. 2000 Aug;14(2):135–46.
8. Ten Eick AP, Blumer JL, Reed MD. Safety of antihistamines in children. Drug Saf. 2001;24(2):119–47. [PubMed]
9. Kiviranta T, Tuomisto L, Airaksien EM. Histamine in cerebrospinal fluid of children with febrile convulsions. Epilepsia. 1995 Mar;36(3):276–80. [PubMed]
10. Churchill JA, Gammon GD. The effect of antihistaminic drugs on convulsive seizures. J Am Med Assoc.1949 Sep;141(1):18–21. [PubMed]
11. Miyata I, Saegusa H, Sakurai M. Seizure-modifying potential of histamine H1 antagonists: A clinical observation. Pediatr Int. 2011 (Oct);53(5):706–08. [PubMed]
12. Takano T, Sakaue Y, Sokoda T, Akabori S, Maruo Y, Taga T, Ohno M, Takeuchi Y. Seizure susceptibility due to antihistamines in febrile seizures. Pediatr Neurol. 2010 Apr;42(4):277–79. [PubMed]
13. Kulkarni R, Valvi C, Kinikar A. Seizure susceptibility due to antihistamines in febrile seizures. Pediatr Neurol. 2010 Oct;43(4):303.
CITATION
DOI: 10.17511/ijmrr.2013.i04.11
Published: 2013-10-31
How to Cite
1.
Patel U, Patel N, Jain R, Ratre B. Antihistaminic Induced Febrile Seizure – An Important association: a Case report. Int J Med Res Rev [Internet]. 2013Oct.31 [cited 2024Nov.8];1(4):216-9. Available from: https://ijmrr.medresearch.in/index.php/ijmrr/article/view/35
Section
Case Report
OAI - Open Archives Initiative
